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Abstract
Abstract
Research in the field of metabolic systems biology requires an apparatus to mimic the physiological conditions necessary for cell growth, but such devices are often costly with laborious methods of metabolite extraction. Our novel miniaturized perfusion bioreactor utilizes cost effective parts and microfluidic PDMS chambers to facilitate multi-trial experimentation with accessible sample extraction. Through an iterative design process, we achieved uniform flow distribution and a leak-free system. To conclude, we designed and fabricated an affordable, high throughput perfusion bioreactor that maintains accuracy at low flow rates of 64.6 + 3.0 μL/min.
Meet The Team
Meet The Team
Allison Furmidge
Allison is a Bioengineering: Bioengineering undergraduate student. She currently works in the Laboratory for Nanobioelectronics on a continuous glucose monitoring sensor.
Chris Claros
Chris is a Bioengineering: Biotechnology undergraduate student. He currently works in the Neural Engineering and Translation Lab that aims to improve neural circuit models for psychiatric disorders.
James Corbitt
James is a Bioengineering: Biotechnology undergraduate student. He currently works in a Biomaterials and Regenerative Medicine Lab that creates hydrogels to treat myocardial infarctions.
Lily Lindmeier
Lily is a Bioengineering: Bioengineering undergraduate student. She currently works in the Tuszynski lab at UC San Diego Health as a research biologist working on projects for 3D printed stem cell scaffolds for spinal cord injuries.
ADVISORS
ADVISORS
Christian Metallo, Ph.D.
Faculty AdvisorDr. Metallo is an Associate Professor in Bioengineering. His lab focuses on metabolic systems biology which applies a multi-disciplinary approach to understanding metabolism and disease.
Jivani Gengatharan
Graduate Student AdvisorJivani is a graduate student in the Metallo lab. She is assisting the senior design group by reviewing design ideas, assisting in obtaining materials, and assisting with equipment procedures such as the YSI and Mass Spectrometer.
Bruce Wheeler, Ph.D.
Senior Project Faculty AdvisorDr. Wheeler is an Adjunct Professor in Bioengineering. He is heavily involved in UCSD's bioengineering senior design courses and the Biosystems track. He is a faculty advisor reviewing senior design projects' goals and logistics.
Katherine Pieri
Senior Project Graduate Student AdvisorKatherine is a graduate student at UCSD. She is also a teaching assistant for the BENG Senior Design courses where she helps undergraduate bioengineering student with their design projects.
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