The Human Body Systems class is a Project Lead the Way course in which students’ learning is facilitated through student inquiry of real world applications. Daily attendance is essential because experiences are obtained through hands-on collaborative labs. Students examine the interactions of human body systems as they explore identity, power, movement, protection, and homeostasis. Students design experiments, investigate the structures and functions of the human body, and use data acquisition software to monitor body functions such as muscle movement, reflex and voluntary action, and respiration. Exploring science in action, students build organs and tissues on a skeletal manikin, work through interesting real world cases and often play roles of biomedical professionals to solve medical mysteries.