Group Availability for Spring 2025 : 7 spots
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Alzheimers is caused by an aggregation of amyloid beta and tau proteins in the brain, but polyphenols, a broad class of compounds, have been shown to inhibit the aggregation of those proteins. As a result, this project aims to focus on expressing different combinations of those proteins through a plasmid vector in bacteria and assaying those proteins for aggregation inhibition. Previous progress has been made through virtual screening to identify potential compounds that effectively inhibit protein aggregation, and those compounds will continue to be analyzed for bioactivity through more computational work and bioassays.