Alumni

Through her thesis she established, along with Dr. Anannya Bandopadhyay and Dr. Kanika Verma that alterations in metabolite levels leads to changes in E. coli proteostasis.

Through his thesis he established, along with Dr. Raj Kumar Asher that oxidative stress response pathways allows efficient translation during reductive stress induced ER-Unfolded Protein Response. He was a joint student with Dr. Shantanu Sengupta from CSIR-IGIB. He is currently a member of the faculty of BITS-Pilani Hyderabad.

Through her thesis (where she worked primarily with Dr. Arnab Mukhopadhyay at NII) she established that transient ER-Unfolded Protein Response at early stages of development in C. elegans can increase longevity.

Through his thesis along with Dr. Shuvadeep Maity, he established that oxidative stress response regulates the amplitude of  ER-Unfolded Protein Response.

Through his thesis (in collaboration with Dr. David Berger) he developed pipelines for analyzing Deep-Mutational-Scanning data and established that trajectories of protein sequence evolution is determined by both protein stability and activity; the trajectory is also altered when metabolite levels are altered.

Through her thesis she established that stress response pathways activated during problems in cytosolic proteostasis imbalance in yeast is not optimal in handling misfolding induced stress response.

Through her thesis, along with Dr. Kanika Saxena, she established that metabolites are integral part of proteostasis network in E. coli.

Through his thesis, where he worked along with Dr. Kanika Verma, he established that E. coli uses metabolic alterations to reinforce proteostasis.

Through his thesis (where he worked as a co-student with Dr. Koyeli Mapa from Shiv Nadar University) he, along with Dr. Satyam Tiwari, established that non-conserved negative charges on GroEL/ES cavity act as string of chemical chaperones to assist substrate folding.

Through her thesis (where she worked as a co-student with Dr. Chetana Sachidanandan), she developed a zebrafish to monitor ER redox potential and establish that ER has heterogeneous distribution of redox potential in a developing zebrafish embryo.

She is currently a faculty member at the Department of Zoology at Delhi University. She worked towards discovering that different small molecules that act as chemical chaperones have different mechanisms of action in vitro and in vivo.

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