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Our laboratory is dedicated to unraveling the intricate relationship between metabolite levels maintained by metabolism and proteostasis, the cell's ability to maintain proper protein function. A central focus of our research lies in identifying the intricate signaling pathways that establish a connection between these two fundamental aspects.
A particularly fascinating dimension we explore is the extent to which nature orchestrates the modulation of metabolite levels to fortify proteostasis mechanisms. This phenomenon not only captivates our scientific curiosity but also opens a realm of boundless opportunities as our comprehension deepens.
Nonetheless, our journey towards unlocking these insights is paved with critical questions that require exploration:
Metabolites and Cellular Proteostasis: Do eukaryotic cells use metabolites as tools to uphold cellular proteostasis? This query delves into the fundamental role of metabolites in maintaining the stability of proteins within cells.
Organelle-Specific Metabolite Regulation: What specific metabolites contribute to proteostasis within distinct cellular organelles? By identifying these metabolites, we gain a nuanced understanding of how different parts of the cell contribute to overall proteostasis.
Tissue-Level Proteostasis Metabolites: Are the metabolites responsible for sustaining proteostasis consistent across various tissues? This comparison sheds light on whether there's a universal set of metabolites ensuring proper protein function or if different tissues employ distinct strategies.
Molecular Attributes of Proteostasis-Associated Metabolites: What molecular characteristics do these small molecules possess that facilitate effective proteostasis? This question probes into the specific features that render certain metabolites pivotal for maintaining protein health.
Synergy between Small Molecules and Protein Chaperones: To what extent do small molecules collaborate with protein chaperones, the cellular assistants that aid in protein folding? Understanding this partnership provides insight into the cooperative strategies cells employ to uphold proteostasis.
The scope of our inquiry is vast and continually expanding...
We are looking for PhD students and Post-docs
We are looking for PhD students and Post-docs
For prospective PhD students:
For prospective PhD students:
We are looking for MS/MBBS/BTech students with valid CSIR/UGC/DBT-BET JRF fellowships (that allow them to work at CSIR- Labs). The candidate does not need to be familiar with our line of work but should be interested in learning biophysical techniques, data analysis, yeast genetics (or mammalian cell culture), molecular biology and protein biochemistry. The candidate should have a sound knowledge in basic chemistry and protein biochemistry. Please write to us if you think you are a good fit for the lab. We will try to set up a meeting to evaluate our fit.
For prospective POST-DOCTORAL Fellows:
For prospective POST-DOCTORAL Fellows:
Should be expert in one or more of the fields mentioned below
Protein engineering and protein biophysics
Protein surface display.
Hands on proteomics/metabolomics with expertise in label-free quantification.
Nanobody/Single chain antibody with focus on generation of mutant libraries and affinity maturation.
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