CBDx

Purpose

Our overall objective is to generate preliminary data in humans on the effects of ingesting a hemp-extract investigational product that contains CBD for reducing pain-related anxiety and symptoms related to induced muscle injury. We aim to determine the efficacy of a controlled short-term trial of hemp-derived CBD ingestion for reducing symptomatic response and facilitating recovery following induced muscle injury. We will assess, in serial fashion, symptomatic response (both physical and psychological factors), functional limitations and recovery of the quadriceps muscle following induced injury in which selected doses of a hemp-derived CBD oil will be administered orally during a 15-day pre-injury consumption and post-injury recovery phase. We will evaluate these responses with an experimental repeated-measure design spanning pre-treatment, baseline measurement, injury induction, short-term sublingual administration of a hemp-derived CBD extract (or placebo) and recovery. 

Strategic Aim 1: To determine time-related patterns of symptomatic and functional recovery in response to sublingual administration of either a low-dose or a high-dose CBD extract after induced muscle injury. 

Strategic Aim 2: To determine the impact of sublingual administration of either a low-dose or high-dose CBD extract on psychological factors known to influence pain intensity and duration. The investigation of psychological constructs will include evaluating the effects of sublingual administration of either a low-dose or high-dose CBD extract on pain-related anxiety, catastrophizing, and fear pertaining to participants' views and perceptions toward engaging in strenuous physical exercise, sustaining a musculoskeletal injury and prolong symptomatic and functional recovery.