Research articles

Qiu K, Vu D, Wang L, Bookstaver A, Dinh TN, Goldfarb AN, Tenen DG, Trinh BQ.  Chromatin structure and 3D architecture define differential functions of PU.1 cis regulatory elements in human blood cell lineages. BioRxiv, 2024  

Ebralidze AK, Umarino S, Bassal MA, Zhang H, Budnik, B, Monteleone E, Kappei D, Liu YV, Tenen DE, Coffey R, Sheen MR, Zhang Y, Wanet A, Trinh BQ, Poli V, Angarica VE, Magallanes RT, Benoukraf T, Crane-Robinson C, Di Ruscio A, Tenen DG. Formation and recycling of an active epigenetic mark mediated by cell cycle-specific RNAs. BioRxiv  

Umarino S, Ebralidze AK, Monteleone E, Zhang Y, Trinh BQ, Di Ruscio A, Tenen DG. S-phase induced RNAs initiate formation of DNA replication origin. BioRxiv  

Zhao X, Bartholdy B, Yamamoto Y, Evans EK, Alberich-Jordà M, Staber P, Benoukraf T, Zhang P, Zhang J, Akef A, Trinh BQ, Crispino JD, Hoang T, Bassal MA, Tenen DG. PU.1 - c-Jun interaction is crucial for PU.1 function in myeloid development. Commun Biol. 2022. PMID: 36104445.

Trinh BQ*, Ummarino S, Zhang Y, Ebralidze AK, Bassal MA, Nguyen TM, Heller G, Coffey R, Tenen DE, van der Kouwe E, Fabiani E, Gurnari C, Wu CS, Angarica VE, Yang H, Chen S, Zhang H, Thurm AR, Marchi F, Levantini E, Staber PB, Zhang P, Voso TM, Pandolfi PP, Kobayashi SS, Chai L, Di Ruscio A & Tenen DG*. Myeloid lncRNA LOUP Mediates Opposing Regulatory Effects of RUNX1 and RUNX1-ETO in t(8;21) AML. Blood Journal. 2021. PMID: 33971010 (*corresponding authors). Editorial commentary. Learn more

Molecular interplay among ncRNA LOUP, RUNX1, and oncogenic protein fusion RUNX1-ETO in mod­ulation of chromatin architecture at the myeloid master gene loci PU.1, and its effects on myeloid development and leu­kemia. URE: en­hancer, PrPr: promoter, RIP-seq: RNA im­munoprecipitation sequencing, ChIP-seq: Chromatin Immuno­precipitation sequencing. (Trinh et al., Blood J, 2021) 

van der Kouwe E, Heller G, Czibere A, Agreiter C, Castilla LH, Delwel R, Di Ruscio A, Ebralidze AK, Forte M, Grebien F, Heyes E, Kazianka L, Klinger J, Kornauth C, Le T, Lind K, Barbosa MA, Pemovska T, Pichler A, Pulikkan JA, Schmolke AS, Schweicker C, Sill H, Sperr W, Spittler A, Surapally S, Trinh BQ, Valent P, Vanura K, Welner RS, Zuber J, Tenen DG, Staber BP. Core binding factor leukemias hijack T-cell prone PU.1 antisense promoter. Blood Journal. 2021. PMID: 34010414. Editorial commentary. Learn more

Umarino S, Hausman C, Gaggi G, Rinaldi L, Bassal MA, Zhang Y, Seelam AJ, Kobayashi IS, Borchiellini M, Ebralidze AK, Ghinassi B, Trinh BQ, Kobayashi SS, Di Ruscio A. NAD modulates DNA methylation and cell differentiation. Cells. 2021. MDPI  

Trinh BQ, Barengo N, Kim SB, Lee JS, Naora H. The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1b and NF-kB signaling. Journal of Cell Science 128(16):3055-67. 2015. PMID: 26208636

Trinh BQ, Ko SY, Haria D, Barengo N, & Naora H. The homeoprotein DLX4 controls ovarian tumor angiogenesis by regulating expression of inducible nitric oxide synthase. Molecular Cancer. Apr 30;14(1):97. 2015. PMID: 25924901

Haria D*, Trinh BQ*, Ko SY, Barengo N, Liu JS & Naora H. The homeoprotein DLX4 stimulates NF-κB activation and CD44-mediated tumor-mesothelial cell interactions in ovarian cancer. American Journal of Pathology 185(8):2298-308. 2015. PMID: 26067154 (*equal contribution)

Trinh BQ, Ko SY, Barengo N, Lin SY, Naora H. Dual functions of the homeoprotein DLX4 in modulating responsiveness of tumor cells to topoisomerase II-targeting drugs. Cancer Research 73:1000-10. 2013.  PMID: 23222298

Trinh BQ, Barengo N, Naora H. Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-b cytostatic program and blocks the anti-proliferative effect of TGF-b. Oncogene 30: 2718-2729. 2011.  PMID: 21297662

Xie X, Hsu JL, Choi MG, Xia W, Yamaguchi H, Chen CT, Trinh BQ, Lu Z, Ueno NT, Wolf JK, Bast RC Jr, Hung MC. A novel hTERT promoter-driven E1A therapeutic for ovarian cancer. Molecular Cancer Therapeutics Aug;8(8):2375-82. 2009. PMID: 19671744

Vu B, Nguyen DK, Trinh BQ, Bach Q, Dinh KD, Dinh VT. Detection and quantification of yellow head virus load in shrimp using Real-Time PCR with SYBR Green. Journal of Science (Hanoi National University). 21(2): 59-65. 2005

Le C, Dai BD, Hoang CM, Nguyen VV, Le DT, Dinh KD, Bach Q, Trinh BQ, Duong QH, Nguyen HH, Nguyen DT, Nguyen DB. Detection of BRCA1 and BRCA2 mutations in breast cancer patients by Real-Time PCR. Proceeding of the National Conference on Basic Research. Institute of Military Medicine. 372-376. October 28, 2004

Trinh BQ, Nguyen BH, Truong NU, Le M, Nguyen H, Dinh KD. 2003. Cloning and expression the region encoding Premembrane and envelope proteins of dengue virus type 4. Journal of Biotechnology 1(1): 33-38. 2003