毎週のラボミーティング(火曜日９時)で論文紹介を行っています。
Recommended papers (?)
2025.10.21
The Plasmodium CSP repeats have elastic properties with a critical role in sporozoite motility
Amanda E Balaban 1 2 , Sachie Kanatani 1 , Jaba Mitra 3 4 , Jason Gregory 1 , Natasha Vartak 1 , Ariadne Sinnis-Bourozikas 1 , Fredrich Frischknecht 5 6 , Taekjip Ha 3 7 8 , Photini Sinnis 9
EMBO J. 2025 Sep 22. doi: 10.1038/s44318-025-00551-9. Online ahead of print.
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2025.9.30
Degradation of ribosomal RNA during Plasmodium falciparum gametocytogenesis
Janne Grünebast, Ritwik Singhal, Robin Bromley, Sachie Kanatani, Kaylee Watson, Sophie Olson, Franck Dumetz , Tales Vicari Pascini, Abhai Tripathi, Julie C Dunning Hotopp, Photini Sinnis, Manuel Llinás, David Serre
mBio. 2025 Sep 22:e0256525. doi: 10.1128/mbio.02565-25
https://pubmed.ncbi.nlm.nih.gov/40980880/
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Plasmodium falciparum PP1 phosphatase is a key regulator of malaria parasite transmission
Ludivine Royer, Emma Colard-Itté , Tatyana Tavella, Audrey Lorthiois, Stéphane Goussin, Marie-Esther N'Dri, Reem Sabra, Auréline Deiss, Sabine Thiberge, Mauld H Lamarque, Catherine Lavazec
mBio. 2025 Sep 10;16(9):e0087425. doi: 10.1128/mbio.00874-25.
https://pubmed.ncbi.nlm.nih.gov/40823845/
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Loss of serine/threonine protein phosphatase 6 severely impairs sexual stage development in malaria parasite Plasmodium berghei
Yonghui Feng, Wenyan Gao, Chengqi Wang, Shuangrui Shi, Dan Zhou, Lin Sun, Liying Zhu, Liwang Cui, Yaming Cao, Xiaotong Zhu
PLoS Pathog. 2025 Jul 7;21(7):e1013318. doi: 10.1371/journal.ppat.1013318.
https://pubmed.ncbi.nlm.nih.gov/40623036/
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Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex
Melanie H Dietrich 1 2 , Jill Chmielewski 1 2 , Li-Jin Chan 1 2 , Li Lynn Tan 1 , Amy Adair 1 , Frankie M T Lyons 1 2 , Mikha Gabriela 1 2 , Sash Lopaticki 1 3 , Toby A Dite 1 2 , Laura F Dagley 1 2 , Lucia Pazzagli 4 , Priya Gupta 4 , Mohd Kamil 4 , Ashley M Vaughan 4 5 , Rattanaporn Rojrung 6 , Anju Abraham 1 , Ramin Mazhari 1 2 , Rhea J Longley 1 2 7 , Kathleen Zeglinski 1 2 , Quentin Gouil 1 2 8 9 , Ivo Mueller 1 2 10 , Stewart A Fabb 11 , Rekha Shandre-Mugan 11 , Colin W Pouton 11 , Alisa Glukhova 1 2 12 13 14 , Shabih Shakeel 1 2 12 14 , Wai-Hong Tham 1 2 15
Science. 2025 Sep 11;389(6765):eady0241. doi: 10.1126/science.ady0241.
https://pubmed.ncbi.nlm.nih.gov/40743371/
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A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei
Mohammad Zeeshan # 1 , Igor Blatov # 1 , Ryuji Yanase # 1 , David J P Ferguson # 2 , Sarah L Pashley 1 , Zeinab Chahine 3 , Yoshiki Yamaryo-Botté 4 , Akancha Mishra 1 , Baptiste Marche 3 , Suhani Bhanvadia 3 , Molly Hair 2 , Sagar Batra 1 , Robert Markus 1 , Declan Brady 1 , Andrew R Bottrill 5 , Sue Vaughan 2 , Cyrille Y Botté 4 , Karine G Le Roch 3 , Anthony A Holder 6 , Eelco Tromer 7 , Rita Tewari 1
Elife. 2025 May 20:14:RP106537. doi: 10.7554/eLife.106537.
https://pubmed.ncbi.nlm.nih.gov/40392232/
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2025.6.10
Antimalarial drug artemisinin stabilizes PfRACK1 binding to the ribosome
Ka Diam Go, Xin-Fu Yan, Grennady Wirjanata, Rya Ero, Samuel Pazicky, Jerzy Dziekan, Seth Tjia, Julien Lescar, Zbynek Bozdech, Yong-Gui Gao
Structure. 2025 May 27:S0969-2126(25)00186-8. doi: 10.1016/j.str.2025.05.008.
https://pubmed.ncbi.nlm.nih.gov/40480224/
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Host complement C3 promotes malaria transmission by killing symbiotic bacteria in the mosquito midgut
Biao He, Meilin Li, Shuai Guo, Feng Zhu, Zhiwei Jiao, Jianyong Li, Nie Tan, Shiming Jiao, Taiping Liu, Jian Zhang, Yongling Fan, Yuanli Gao, Taoli Zhou, Jian Li, Wei Huang, Lubin Jiang, Zurui Lin, Sibao Wang, Wenyue Xu
Proc Natl Acad Sci U S A. 2025 Jun 3;122(22):e2424570122. doi: 10.1073/pnas.2424570122.
https://pubmed.ncbi.nlm.nih.gov/40434644/
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Identification of a large anion channel required for digestive vacuole acidification and amino acid export in Plasmodium falciparum
Gagandeep S Saggu, Jinfeng Shao, Mansoor A Siddiqui, Maria Traver, Tatiane Macedo-Silva, Joseph Brzostowski, Sanjay A Desai
PLoS Biol. 2025 May 30;23(5):e3003202. doi: 10.1371/journal.pbio.3003202.
https://pubmed.ncbi.nlm.nih.gov/40446075/
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Identifying antimalarials that disrupt malaria parasite transmission when fed to the mosquito
Sarah N Farrell, Anton Cozijnsen, Vanessa Mollard, Papireddy Kancharla, Rozalia A Dodean, Jane X Kelly, Geoffrey I McFadden, Christopher D Goodman
Int J Parasitol. 2025 May 29:S0020-7519(25)00096-7. doi: 10.1016/j.ijpara.2025.05.005.
https://pubmed.ncbi.nlm.nih.gov/40449870/
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Heterochromatin de novo formation and maintenance in Plasmodium falciparum
Alba Pérez-Cantero, Oriol Llorà-Batlle, Ingrid Pelaez-Conde, César Martínez-Guardiola, Alfred Cortés
PLoS Pathog. 2025 Jun 2;21(6):e1013137. doi: 10.1371/journal.ppat.1013137.
https://pubmed.ncbi.nlm.nih.gov/40455742/
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β-hydroxybutyrate inhibits Plasmodium falciparum development and confers protection against malaria in mice
Zhiming Wei, Ning Jiang, Yiwei Zhang, Qilong Li, Ziwei Su, Yanxin Zhang, Kunying Lv, Yixin Yang, Tong Liu, Lu Sun, Kexin Zheng, Ang Li, Anni Feng, Xiaoyu Sang, Ying Feng, Ran Chen, Qijun Chen
Nat Metab. 2025 May 23. doi: 10.1038/s42255-025-01302-0.
https://pubmed.ncbi.nlm.nih.gov/40410577/
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PfPPM2 signalling regulates asexual division and sexual conversion of human malaria parasite Plasmodium falciparum
Akanksha Rawat 1 , Neelam Antil 2 , Meenakshi 1 , Bhagyashree Deshmukh 3 , Akhila Balakrishna Rai 2 , Annu Nagar 1 , Narendra Kumar 1 3 , T S Keshava Prasad 2 , Krishanpal Karmodiya 4 , Pushkar Sharma 5
Nat Commun. 2025 May 23;16(1):4790. doi: 10.1038/s41467-025-59476-w.
https://pubmed.ncbi.nlm.nih.gov/40410154/
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Structural elucidation of full-length Pfs48/45 in complex with potent monoclonal antibodies isolated from a naturally exposed individual
Iga Kucharska # 1 , Danton Ivanochko # 1 , Sophia Hailemariam # 1 2 , Maartje R Inklaar 3 , Hee Ryung Kim 1 , Karina Teelen 3 , Rianne Stoter 3 , Marga van de Vegte-Bolmer 3 , Geert-Jan van Gemert 3 , Anthony Semesi 1 , Brandon McLeod 1 2 , Ahyoung Ki 4 , Won-Kyu Lee 4 , John L Rubinstein 1 2 5 , Matthijs M Jore 3 , Jean-Philippe Julien 6 7 8
Nat Struct Mol Biol. 2025 May 22. doi: 10.1038/s41594-025-01532-6.
https://pubmed.ncbi.nlm.nih.gov/40404982/
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In vivo screen of Plasmodium targets for mosquito-based malaria control
Alexandra S Probst # 1 , Douglas G Paton # 1 2 , Federico Appetecchia 1 , Selina Bopp 1 , Kelsey L Adams 1 , Tasneem A Rinvee 1 , Sovitj Pou 3 , Rolf Winter 3 , Esrah W Du 1 , Sabrina Yahiya 4 , Charles Vidoudez 5 , Naresh Singh 1 , Janneth Rodrigues 6 , Pablo Castañeda-Casado 6 , Chiara Tammaro 7 , Daisy Chen 8 , Karla P Godinez-Macias 8 , Jasmine L Jaramillo 9 , Giovanna Poce 7 , Michael J Rubal 9 , Aaron Nilsen 3 10 , Elizabeth A Winzeler 8 , Jake Baum 4 11 , Jeremy N Burrows 12 , Michael K Riscoe 3 10 , Dyann F Wirth 13 14 , Flaminia Catteruccia 15 16
Nature. 2025 May 21. doi: 10.1038/s41586-025-09039-2
https://pubmed.ncbi.nlm.nih.gov/40399670/
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The fast-evolving FIKK kinase family of Plasmodium falciparum can be inhibited by a single compound
Hugo Belda # 1 2 , David Bradley # 3 4 5 , Evangelos Christodoulou 6 , Stephanie D Nofal 1 2 , Malgorzata Broncel 1 , David Jones 1 , Heledd Davies 1 , M Teresa Bertran 7 , Andrew G Purkiss 6 , Roksana W Ogrodowicz 6 , Dhira Joshi 8 , Nicola O'Reilly 8 , Louise Walport 7 , Andrew Powell 9 , David House 9 , Svend Kjaer 6 , Antoine Claessens 10 , Christian R Landry 3 4 5 , Moritz Treeck 11 12
Nat Microbiol. 2025 Jun;10(6):1463-1483. doi: 10.1038/s41564-025-02017-4.
https://pubmed.ncbi.nlm.nih.gov/40389650/
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2025.5.8
A CRISPR homing screen finds a chloroquine resistance transporter-like protein of the Plasmodium oocyst essential for mosquito transmission of malaria
Arjun Balakrishnan, Mirjam Hunziker, Puja Tiwary, Vikash Pandey, David Drew, Oliver Billker
Nat Commun. 2025 Apr 24;16(1):3895. doi: 10.1038/s41467-025-59099-1.
https://pubmed.ncbi.nlm.nih.gov/40274854/
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PfGCN5 is essential for Plasmodium falciparum survival and transmission and regulates Pf H2B.Z acetylation and chromatin structure
Jingyi Tang, Lee M Yeoh, Myriam D Grotz, Christopher D Goodman, Scott A Chisholm, Hanh H T Nguyen, Chunhao Yu, Kapil Pareek, Fairley McPherson, Anton Cozijnsen, Samuel A Hustadt, Gabrielle A Josling, Karen P Day, Danae Schulz, Geoffrey I McFadden, Tania F de Koning-Ward, Michaela Petter , Michael F Duffy
Nucleic Acids Res. 2025 Mar 20;53(6):gkaf218. doi: 10.1093/nar/gkaf218.
https://pubmed.ncbi.nlm.nih.gov/40156869/
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Pf MORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum
Zeinab M Chahine, Mohit Gupta, Todd Lenz, Thomas Hollin, Steven Abel, Charles Banks, Anita Saraf, Jacques Prudhomme, Suhani Bhanvadia, Laurence A Florens, Karine G Le Roch
Elife. 2024 Dec 5:12:RP92499. doi: 10.7554/eLife.92499.
https://pubmed.ncbi.nlm.nih.gov/39636094/
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Activity-based protein profiling reveals both canonical and novel ubiquitin pathway enzymes in Plasmodium
Cameron Smith, Mohsen Hajisadeghian, Gerbrand J van der Heden van Noort, Michael J Deery, Adán Pinto-Fernández, Benedikt M Kessler, Katerina Artavanis-Tsakonas
PLoS Pathog. 2025 Apr 18;21(4):e1013032. doi: 10.1371/journal.ppat.1013032. eCollection 2025 Apr.
https://pubmed.ncbi.nlm.nih.gov/40249735/
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Type I interferons induce guanylate-binding proteins and lysosomal defense in hepatocytes to control malaria
Camila Marques-da-Silva, Clyde Schmidt-Silva, Carson Bowers, Nana Appiah Essel Charles-Chess, Cristina Samuel, Justine C Shiau, Eui-Soon Par, Zhongyu Yuan, Bae-Hoon Kim, Dennis E Kyle, John T Harty, John D MacMicking, Samarchith P Kurup
Cell Host Microbe. 2025 Apr 9;33(4):529-544.e9. doi: 10.1016/j.chom.2025.03.008. Epub 2025 Mar 31.
https://pubmed.ncbi.nlm.nih.gov/40168996/
This paper was commented in: https://www.cell.com/cell-host-microbe/abstract/S1931-3128(25)00090-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1931312825000903%3Fshowall%3Dtrue
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HOPS/CORVET tethering complexes are critical for endocytosis and protein trafficking to invasion related organelles in malaria parasites
Joëlle Paolo Mesén-Ramírez, Gwendolin Fuchs, Jonas Burmester, Guilherme B Farias, Ana María Alape-Flores, Shamit Singla, Arne Alder, José Cubillán-Marín, Carolina Castro-Peña, Sarah Lemcke, Holger Sondermann, Mónica Prado, Tobias Spielmann, Danny Wilson, Tim-Wolf Gilberger
PLoS Pathog. 2025 Apr 8;21(4):e1013053. doi: 10.1371/journal.ppat.1013053. eCollection 2025 Apr.
https://pubmed.ncbi.nlm.nih.gov/40198740/
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Malaria parasites undergo a rapid and extensive metamorphosis after invasion of the host erythrocyte
Aline Fréville, Flavia Moreira-Leite, Camille Roussel, Matthew R G Russell, Aurelie Fricot, Valentine Carret, Abdoulaye Sissoko, Matthew J Hayes, Aissatou Bailo Diallo, Nicole Cristine Kerkhoven, Margarida Ressurreição, Safi Dokmak, Michael J Blackman, Lucy M Collinson, Pierre A Buffet, Sue Vaughan, Papa Alioune Ndour, Christiaan van Ooij
EMBO Rep. 2025 Apr 4. doi: 10.1038/s44319-025-00435-3. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/40185976/
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Parasite and vector circadian clocks mediate efficient malaria transmission
Inês Bento, Brianna A Parrington, Rushlenne Pascual, Alexander S Goldberg, Eileen Wang, Hani Liu, Helene Borrmann, Mira Zelle, Nicholas Coburn, Joseph S Takahashi, Joshua E Elia, Maria M Mota, Filipa Rijo-Ferreira
Nat Microbiol. 2025 Apr;10(4):882-896. doi: 10.1038/s41564-025-01949-1. Epub 2025 Mar 31.
https://pubmed.ncbi.nlm.nih.gov/40164831/
Maybe this paper is a little difficult.
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Molecular basis of the functional conflict between chloroquine and peptide transport in the Malaria parasite chloroquine resistance transporter PfCRT
John D Tanner, Sashika N Richards, Ben Corry
Nat Commun. 2025 Mar 27;16(1):2987. doi: 10.1038/s41467-025-58244-0.
https://pubmed.ncbi.nlm.nih.gov/40140375/
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Divergent Plasmodium kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis
Ryuji Yanase, Mohammad Zeeshan, David Jp Ferguson, Robert Markus, Declan Brady, Andrew R Bottrill, Anthony A Holder, David S Guttery, Rita Tewari
Life Sci Alliance. 2025 Mar 24;8(6):e202403056. doi: 10.26508/lsa.202403056. Print 2025 Jun.
https://pubmed.ncbi.nlm.nih.gov/40127922/
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Molecular architecture of glideosome and nuclear F-actin in Plasmodium falciparum
Vojtěch Pražák, Daven Vasishtan, Kay Grünewald, Ross G Douglas, Josie L Ferreira
EMBO Rep. 2025 Apr;26(8):1984-1996. doi: 10.1038/s44319-025-00415-7. Epub 2025 Mar 24.
https://pubmed.ncbi.nlm.nih.gov/40128412/
Please also read their previous paper (https://pubmed.ncbi.nlm.nih.gov/36869034/ ).
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The dynamin-related protein PfDyn2 is essential for both apicoplast and mitochondrial fission in Plasmodium falciparum
Alexander A Morano, Wei Xu, Francesca M Navarro, Neeta Shadija, Jeffrey D Dvorin, Hangjun Ke
mBio. 2025 Jan 8;16(1):e0303624. doi: 10.1128/mbio.03036-24. Epub 2024 Nov 29.
https://pubmed.ncbi.nlm.nih.gov/39611847/
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tRNA lysidinylation is essential for the minimal translation system in the Plasmodium falciparum apicoplast
Rubayet Elahi, Sean T Prigge
EMBO Rep. 2025 Mar 20. doi: 10.1038/s44319-025-00420-w. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/40113990/
Please carefully check their previous papers in the reference.
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Plasmodium blood stage development requires the chromatin remodeller Snf2L
Maria Theresia Watzlowik, Elisabeth Silberhorn, Sujaan Das, Ritwik Singhal, Kannan Venugopal, Simon Holzinger, Barbara Stokes, Ella Schadt, Lauriane Sollelis, Victoria A Bonnell, Matthew Gow, Andreas Klingl, Matthias Marti , Manuel Llinás, Markus Meissner, Gernot Längst
Nature. 2025 Mar;639(8056):1069-1075. doi: 10.1038/s41586-025-08595-x. Epub 2025 Feb 19.
https://pubmed.ncbi.nlm.nih.gov/39972139/
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DNA replication dynamics are associated with genome composition in Plasmodium species
Francis Isidore Garcia Totañes, Sarah E Chapman, Subash Kumar Rai, Mathew J K Jones, Michael A Boemo, Catherine J Merrick
Nucleic Acids Res. 2025 Feb 8;53(4):gkaf111. doi: 10.1093/nar/gkaf111.
https://pubmed.ncbi.nlm.nih.gov/39997219/
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iDC-targeting PfCSP mRNA vaccine confers superior protection against Plasmodium compared to conventional mRNA
Sean Yanik, Varsha Venkatesh, James T Gordy, Mohamad-Gabriel Alameh, Jacob Meza, Yangchen Li, Elizabeth Glass, Yevel Flores-Garcia, Ying Tam, Nattawat Chaiyawong , Deepti Sarkar, Drew Weissman, Richard Markham, Prakash Srinivasan
NPJ Vaccines. 2025 Feb 19;10(1):34. doi: 10.1038/s41541-025-01089-x.
https://pubmed.ncbi.nlm.nih.gov/39971939/
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2024.7.4
Plasmodium falciparum gametocyte production correlates with genetic markers of parasite replication but is not influenced by experimental exposure to mosquito biting
Sara Lynn Blanken, Aissata Barry, Kjerstin Lanke, Moussa Guelbeogo, Alphonse Ouedraogo, Issiaka Soulama, Sam Aboubacar Coulibaly, Karina Teelen, Wouter Graumans, Elin Dumont, Will Stone, Jordache Ramjith, Matthias Marti, Carolina M Andrade, Chris Drakeley, Katharine Collins, Alfred Tiono, Teun Bousema
EBioMedicine. 2024 Jun 19:105:105190. doi: 10.1016/j.ebiom.2024.105190. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/38901148/
2024.5.16
tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum
Jennifer L Small-Saunders, Ameya Sinha, Talia S Bloxham, Laura M Hagenah, Guangxin Sun, Peter R Preiser, Peter C Dedon, David A Fidock
Nat Microbiol. 2024 Apr 17. doi: 10.1038/s41564-024-01664-3. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/38632343/
Transcriptional heterogeneity and tightly regulated changes in gene expression during Plasmodium berghei sporozoite development
Haikel N Bogale, Tales V Pascini, Sachie Kanatani, Juliana M Sá, Thomas E Wellems, Photini Sinnis, Joel Vega-Rodríguez, David Serre
Proc Natl Acad Sci USA. 2021 Mar 9;118(10):e2023438118. doi: 10.1073/pnas.2023438118.
https://pubmed.ncbi.nlm.nih.gov/33653959/
2024.2.9
Extracellular vesicles could be a putative posttranscriptional regulatory mechanism that shapes intracellular RNA levels in Plasmodium falciparum
Mwikali Kioko , Alena Pance, Shaban Mwangi, David Goulding, Alison Kemp, Martin Rono, Lynette Isabella Ochola-Oyier, Pete C Bull, Philip Bejon, Julian C Rayner, Abdirahman I Abdi
Nat Commun. 2023 Oct 13;14(1):6447. doi: 10.1038/s41467-023-42103-x.
https://pubmed.ncbi.nlm.nih.gov/37833314/
Protein kinase PfPK2 mediated signalling is critical for host erythrocyte invasion by malaria parasite
Rahul Singh Rawat, Ankit Gupta, Neelam Antil, Sonika Bhatnagar, Monika Singh, Akanksha Rawat, T S Keshava Prasad , Pushkar Sharma
PLoS Pathog. 2023 Nov 21;19(11):e1011770. doi: 10.1371/journal.ppat.1011770. eCollection 2023 Nov.
https://pubmed.ncbi.nlm.nih.gov/37988347/
2024.1.31 by Shinzawa
Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes
Wei Huang, Janneth Rodrigues, Etienne Bilgo, José R Tormo, Joseph D Challenger, Cristina De Cozar-Gallardo, Ignacio Pérez-Victoria, Fernando Reyes, Pablo Castañeda-Casado, Edounou Jacques Gnambani, Domonbabele François de Sales Hien, Maurice Konkobo, Beatriz Urones, Isabelle Coppens, Alfonso Mendoza-Losana, Lluís Ballell, Abdoulaye Diabate, Thomas S Churcher, Marcelo Jacobs-Lorena
Science. 2023 Aug 4;381(6657):533-540. doi: 10.1126/science.adf8141. Epub 2023 Aug 3.
https://pubmed.ncbi.nlm.nih.gov/37535741/
Cryptosporidium uses multiple distinct secretory organelles to interact with and modify its host cell
Amandine Guérin, Katherine M. Strelau, Konstantin Barylyuk, Bethan A. Wallbank, Laurence Berry, Oliver M. Crook, Kathryn S. Lilley, Ross F. Waller,, Boris Striepen
Cell Host Microbe. 2023 Apr 12;31(4):650-664.e6. doi: 10.1016/j.chom.2023.03.001.
https://pubmed.ncbi.nlm.nih.gov/36958336/
Antiplasmodial peptaibols act through membrane directed mechanisms
Jennifer E. Collins, Jin Woo Lee, Frances Rocamora, Gagandeep S. Saggu, Karen L. Wendt, Charisse Flerida A. Pasaje, Sebastian Smick, Natalia Mojica Santos, Raphaella Paes, Tiantian Jiang, Nimisha Mittal, Madeline R. Luth, Taylor Chin, Howard Chang, James L. McLellan, Beatriz Morales-Hernandez, Kirsten K. Hanson, Jacquin C. Niles, Sanjay A. Desai, Elizabeth A. Winzeler, Robert H. Cichewicz, Debopam Chakrabarti
Cell Chem Biol. 2023 Nov 13:S2451-9456(23)00385-9. doi: 10.1016/j.chembiol.2023.10.025.
https://pubmed.ncbi.nlm.nih.gov/37995692/
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness
Sachel Mok, Tomas Yeo, Davin Hong, Melanie J Shears, Leila S Ross, Kurt E Ward, Satish K Dhingra, Mariko Kanai, Jessica L Bridgford, Abhai K Tripathi, Godfree Mlambo, Anna Y Burkhard, Megan R Ansbro, Kate J Fairhurst, Eva Gil-Iturbe, Heekuk Park, Felix D Rozenberg, Jonathan Kim, Filippo Mancia, Rick M Fairhurst, Matthias Quick, Anne-Catrin Uhlemann, Photini Sinnis, David A Fidock
Sci Adv. 2023 Nov 10;9(45):eadi2364. doi: 10.1126/sciadv.adi2364. Epub 2023 Nov 8.
https://pubmed.ncbi.nlm.nih.gov/37939186/
Gene-by-gene screen of the unknown proteins encoded on Plasmodium falciparum chromosome 3
Jessica Kimmel, Marius Schmitt, Alexej Sinner, Pascal Wilhelmus Theodorus Christianus Jansen, Sheila Mainye, Gala Ramón-Zamorano, Christa Geeke Toenhake, Jan Stephan Wichers-Misterek, Jakob Cronshagen, Ricarda Sabitzki, Paolo Mesén-Ramírez, Hannah Michaela Behrens, Richárd Bártfai, Tobias Spielmann
Cell Syst. 2023 Jan 18;14(1):9-23.e7. doi: 10.1016/j.cels.2022.12.001.
https://pubmed.ncbi.nlm.nih.gov/36657393/
Revisiting the Plasmodium sporozoite inoculum and elucidating the efficiency with which malaria parasites progress through the mosquito
Sachie Kanatani, Deborah Stiffler, Teun Bousema, Gayane Yenokyan, Photini Sinnis
Nat Commun. 2024 Jan 25;15(1):748. doi: 10.1038/s41467-024-44962-4.
https://pubmed.ncbi.nlm.nih.gov/38272943/
Requirement of microtubules for secretion of a micronemal protein CpTSP4 in the invasive stage of the apicomplexan Cryptosporidium parvum
Dongqiang Wang, Peng Jiang , Xiaodong Wu, Ying Zhang, Chenchen Wang, Meng Li, Mingxiao Liu, Jigang Yin, Guan Zhu
mBio. 2024 Jan 24:e0315823. doi: 10.1128/mbio.03158-23. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/38265238/
A population modification gene drive targeting both Saglin and Lipophorin impairs Plasmodium transmission in Anopheles mosquitoes
Emily I GreenEtienne JaouenDennis KlugRoenick Proveti OlmoAmandine GautierStéphanie BlandinEric Marois
Elife. 2023 Dec 5:12:e93142. doi: 10.7554/eLife.93142.
https://pubmed.ncbi.nlm.nih.gov/38051195/
Intracellular Plasmodium aquaporin 2 is important for sporozoite production in the mosquito vector and malaria transmission
Alexander J. Bailey, Chiamaka Valerie Ukegbu, Maria Giorgalli, Tanguy Rene Balthazar Besson, George K. Christophides,, Dina Vlachou
Proc Natl Acad Sci U S A. 2023 Oct 31;120(44):e2304339120. doi: 10.1073/pnas.2304339120.
https://pubmed.ncbi.nlm.nih.gov/37883438/
Clinically relevant atovaquone-resistant human malaria parasites fail to transmit by mosquito
Victoria A. Balta, Deborah Stiffler, Abeer Sayeed, Abhai K. Tripathi, Rubayet Elahi, Godfree Mlambo, Rahul P. Bakshi, Amanda G. Dziedzic, Anne E. Jedlicka, Elizabeth Nenortas, Keyla Romero-Rodriguez, Matthew A. Canonizado, Alexis Mann, Andrew Owen, David J. Sullivan, Sean T. Prigge, Photini Sinnis, Theresa A. Shapiro
Nat Commun. 2023 Oct 12;14(1):6415. doi: 10.1038/s41467-023-42030-x.
https://pubmed.ncbi.nlm.nih.gov/37828012/
Origin and arrangement of actin filaments for gliding motility in apicomplexan parasites revealed by cryo-electron tomography
Matthew Martinez, Shrawan Kumar Mageswaran, Amandine Guérin, William David Chen, Cameron Parker Thompson, Sabine Chavin, Dominique Soldati-Favre, Boris Striepen, Yi-Wei Chan
Nat Commun. 2023 Aug 9;14(1):4800. doi: 10.1038/s41467-023-40520-6.
https://pubmed.ncbi.nlm.nih.gov/37558667/
mRNA vaccine against malaria tailored for liver-resident memory T cells
Mitch Ganley, Lauren E. Holz, Jordan J. Minnell, Maria N. de Menezes, Olivia K. Burn, Kean Chan Yew Poa, Sarah L. Draper, Kieran English, Susanna T. S. Chan, Regan J. Anderson, Benjamin J. Compton, Andrew J. Marshall, Anton Cozijnsen, Yu Cheng Chua, Zhengyu Ge, Kathryn J. Farrand, John C. Mamum, Calvin Xu, Ian A. Cockburn, Katsuyuki Yui, Patrick Bertolino, Stephanie Gras, Jérôme Le Nours, Jamie Rossjohn, Daniel Fernandez-Ruiz, Geoffrey I. McFadden, David F. Ackerley, Gavin F. Painter, Ian F. Hermans, William R. Heath
Nat Immunol. 2023 Sep;24(9):1487-1498. doi: 10.1038/s41590-023-01562-6.
https://pubmed.ncbi.nlm.nih.gov/37474653/
Dual effector population modification gene-drive strains of the African malaria mosquitoes, Anopheles gambiae and Anopheles coluzzii
Rebeca Carballar-Lejarazú, Yuemei Dong, Thai Binh Pham, Taylor Tushar, Rodrigo M. Corder, Agastya Mondal, Héctor M. Sánchez C, Hsu-Feng Lee, John M. Marshall, George Dimopoulos, Anthony A. James
Proc Natl Acad Sci U S A. 2023 Jul 18;120(29):e2221118120. doi: 10.1073/pnas.2221118120.
https://pubmed.ncbi.nlm.nih.gov/37428915/
Selection for insecticide resistance can promote Plasmodium falciparum infection in Anopheles
Kelsey L. Adams, Emily K. Selland, Bailey C. Willett, John W. Carew, Charles Vidoudez, Naresh Singh, Flaminia Catteruccia
PLoS Pathog. 2023 Jun 20;19(6):e1011448. doi: 10.1371/journal.ppat.1011448.
https://pubmed.ncbi.nlm.nih.gov/37339122/
Conformational change of Plasmodium TRAP is essential for sporozoite migration and transmission
Friedrich Braumann, Dennis Klug, Jessica Kehrer, Gaojie Song, Juan Feng, Timothy A Springer, Friedrich Frischknecht
EMBO Rep. 2023 Jul 5;24(7):e57064. doi: 10.15252/embr.202357064.
https://pubmed.ncbi.nlm.nih.gov/37306042/
Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies
Opeyemi Ernest Oludada, Giulia Costa, Clare Burn Aschner, Anna S Obraztsova, Katherine Prieto, Caterina Canetta, Stephen L Hoffman, Peter G Kremsner, Benjamin Mordmüller, Rajagopal Murugan, Jean‐Philippe Julien, Elena A Levashina, Hedda Wardemann
EMBO Mol Med. 2023 Jun 7;15(6):e17454. doi: 10.15252/emmm.202317454.
https://pubmed.ncbi.nlm.nih.gov/37082831/
The claudin-like apicomplexan microneme protein is required for gliding motility and infectivity of Plasmodium sporozoites
Manon Loubens, Carine Marinach, Clara-Eva Paquereau, Soumia Hamada, Bénédicte Hoareau-Coudert, David Akbar, Jean-François Franetich, Olivier Silvie
PLoS Pathog. 2023 Mar 16;19(3):e1011261. doi: 10.1371/journal.ppat.1011261.
https://pubmed.ncbi.nlm.nih.gov/36928686/
The salivary protein Saglin facilitates efficient midgut colonization of Anopheles mosquitoes by malaria parasites
Dennis Klug , Amandine Gautier, Eric Calvo, Eric Marois, Stéphanie A. Blandin
PLoS Pathog. 2023 Mar 2;19(3):e1010538. doi: 10.1371/journal.ppat.1010538.
https://pubmed.ncbi.nlm.nih.gov/36862755/
A Microtubule-Associated Protein Is Essential for Malaria Parasite Transmission
Jan Stephan Wichers-Misterek, Annika M. Binder, Paolo Mesén-Ramírez, Lilian Patrick Dorner, Soraya Safavi, Gwendolin Fuchs, Tobias L. Lenz, Anna Bachmann, Danny Wilson, Friedrich Frischknecht, Tim-Wolf Gilberger
mBio. 2023 Feb 28;14(1):e0331822. doi: 10.1128/mbio.03318-22.
https://pubmed.ncbi.nlm.nih.gov/36625655/
Knock-sideways by inducible ER retrieval enables a unique approach for studying Plasmodium- secreted proteins
Manuel A Fierro, Tahir Hussain, Liam J Campin, Josh R Beck
Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2308676120. doi: 10.1073/pnas.2308676120.
https://pubmed.ncbi.nlm.nih.gov/37552754/
Plasmodium ARK2 and EB1 drive unconventional spindle dynamics, during chromosome segregation in sexual transmission stages
Mohammad Zeeshan, Edward Rea, Steven Abel, Kruno Vukušić, Robert Markus, Declan Brady, Antonius Eze, Ravish Rashpa, Aurelia C. Balestra, Andrew R. Bottrill, Mathieu Brochet, David S. Guttery, Iva M. Tolić, Anthony A. Holder, Karine G. Le Roch, Eelco C. Tromer, Rita Tewari
Nat Commun. 2023 Sep 13;14(1):5652. doi: 10.1038/s41467-023-41395-3.
https://pubmed.ncbi.nlm.nih.gov/37704606/
The following two papers should be introduced at the same time:
A spatiotemporally resolved single-cell atlas of the Plasmodium liver stage
Amichay Afriat, Vanessa Zuzarte-Luís, Keren Bahar Halpern, Lisa Buchauer, Sofia Marques, Ângelo Ferreira Chora, Aparajita Lahree, Ido Amit, Maria M. Mota, Shalev Itzkovitz
Nature. 2022 Nov;611(7936):563-569. doi: 10.1038/s41586-022-05406-5.
https://pubmed.ncbi.nlm.nih.gov/36352220/
A single-cell liver atlas of Plasmodium vivax infection
Liliana Mancio-Silva , Nil Gural, Eliana Real, Marc H Wadsworth 2nd, Vincent L Butty, Sandra March, Niketa Nerurkar, Travis K Hughes, Wanlapa Roobsoong, Heather E Fleming, Charlie A Whittaker, Stuart S Levine, Jetsumon Sattabongkot, Alex K Shalek, Sangeeta N Bhatia
Cell Host Microbe. 2022 Jul 13;30(7):1048-1060.e5. doi: 10.1016/j.chom.2022.03.034.
https://pubmed.ncbi.nlm.nih.gov/35443155/
Plasmodium invasion related
https://pubmed.ncbi.nlm.nih.gov/37713419/
https://pubmed.ncbi.nlm.nih.gov/37712738/
https://pubmed.ncbi.nlm.nih.gov/37708854/
https://pubmed.ncbi.nlm.nih.gov/37607941/
https://pubmed.ncbi.nlm.nih.gov/37489900/
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011449
Past Journal Clubs
2025
250206
The malaria parasite PP1 phosphatase controls the initiation of the egress pathway of asexual blood-stages by regulating the rounding-up of the vacuole, PLOS Pathogens (Quratul-ain)
Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver, npj vaccines (Sekine)
250227
Plasmodium NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation, PLOS Biology (Mark)
Genome-wide gene expression profiles throughout human malaria parasite liver stage development in humanized mice, Nature Microbiology (Kegawa)
250403
Elevated NAD+ drives Sir2A-mediated GCβ deacetylation and OES localization for Plasmodium ookinete gliding and mosquito infection, Nature communications (Tay)
Late killing of Plasmodium berghei sporozoites in the liver by an anti-circumsporozoite protein antibody, eLife (Baba)
250417
Anopheles gambiae phagocytic hemocytes promote Plasmodium falciparum infection by regulating midgut epithelial integrity, Nature communications (Sekine)
250508
APEX2‑based proximity proteomic analysis identifies candidate interactors for Plasmodium falciparum knob‑associated histidine‑rich protein in infected erythrocytes, Scientific reports (Quratul-ain)
2024
240125
EXP1 is required for organisation of EXP2 in the intraerythrocytic malaria parasite vacuole, Cellular Microbiology (Sekine)
Putative prefoldin complex subunit 5 of Plasmodium berghei is crucial for microtubule formation and parasite development in the mosquito,Molecular Microbiology (Baba)
240208
TDNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages, Nature Microbiology (Shinzawa)
240404
Knock-sideways by inducible ER retrieval enables a unique approach for studying Plasmodium-secreted proteins, PNAS (Mark)
240418
Protein kinase PfPK2 mediated signalling is critical for host erythrocyte invasion by malaria parasite, PLOS Pathogens (Tay)
Atlas of Plasmodium falciparum intraerythrocytic development using expansion microscopy, eLife (Shinzawa)
240509
Essential function of alveolin PfIMC1g in the Plasmodium falciparum asexual blood stage, mBio (Quratul-ain)
The salivary protein Saglin facilitates efficient midgut colonization of Anopheles mosquitoes by malaria parasites, PLOS Pathogens (Sekine)
240523
The claudin-like apicomplexan microneme protein is required for gliding motility and infectivity of Plasmodium sporozoites, Molecular Microbiology, (Mark)
Mosquito midgut stem cell cellular defense response limits Plasmodium parasite infection, Nature Communications (Sekine)
240606
Endoplasmic reticulum localized TMEM33 domain-containing protein is crucial for all life cycle stages of the malaria parasite, Molevular Biology (Tay)
Identification of a non-exported Plasmepsin V substrate that functions in the parasitophorous vacuole of malaria parasites, mBio (Quratul-ain)
240704
The novel Plasmodium berghei protein S14 is essential for sporozoite gliding motility and infectivity, Journal of Cell Science (Mark)
Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes, Science (Sekine)
240718
tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum, Nature Microbiology (Okada)
241017
Endoplasmic reticulum localized TMEM33 domain-containing protein is crucial for all life cycle stages of the malaria parasite, Molecular Microbiology (Mark)
241031
Toxoplasma gondii rhoptry discharge factor 3 is essential for invasion and microtubule-associated vesicle biogenesis, PLOS Biology (Kegawa)
Trophoblast surface becomes refractory to adhesion by congenitally transmitted Toxoplasma gondii and Listeria monocytogenes during cytotrophoblast to syncytiotrophoblast development, mSphere (Baba)
241114
Selection for insecticide resistance can promote Plasmodium falciparum infection in Anopheles, PLOS Pathogens (Sekine)
241212
Flp/FRT- mediated disruption of ptex150 and exp2 in Plasmodium falciparum sporozoites inhibits liver-stage development, Cell Press, PNAS (Tay)
An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis, Cell (Shinzawa)
2023
230202
Malaria parasites harness Rho GTPase signaling and host cell membrane ruffling for productive invasion of hepatocytes, Cell Reports (Okada)
PTEX Pore Component EXP2 Is Important for Intrahepatic Development during the Plasmodium Liver Stage, mBio (Tay)
230413
Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis, Cell Host Microbe (Sekine)
230427
Chemogenomic Profiling of a Plasmodium falciparum Transposon Mutant Library Reveals Shared Effects of Dihydroartemisinin and Bortezomib on Lipid Metabolism and Exported Proteins, mSphere (Kubota)
Plasmodium 6-cysteine proteins determine the commitment of sporozoites to liver-infection, Parasitology International (Mark)
230518
A transcriptional switch controls sex determination in Plasmodium falciparum., Nature (Shinzawa)
Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasion., Nature Communications (Quratul-ain)
230608
Plasmodium sporozoite disintegration during skin passage limits malaria parasite transmission, EMBO (Okada)
Plasmodium parasitophorous vacuole membrane resident protein UIS4 manipulates host cell actin to avoid parasite elimination, iScience (Tay)
230622
Formation of ER-lumenal intermediates during export of Plasmodium proteins containing transmembrane-like hydrophobic sequences, PLOS Pathogens, (Kubota)
Elucidation of the liver pathophysiology of COVID-19 patients using liver-on-a-chips, PNAS Nexus (Sekine)
Temperature-dependent RNA editing in octopus extensively recodes the neural proteome, Cell (Kumagai)
Plasmodium sporozoites require the protein B9 to invade hepatocytes, iScience (Mark)
230713
Plasmodium early transcribed membrane proteins appear tailored to the host range of malaria parasites, International Journal for Parasitology (Akiyama)
Maturation and substrate processing topography of the Plasmodium falciparum invasion/egress protease plasmepsin X, Nature Communications (Katase)
230914
Cytotoxicity of human antibodies targeting the circumsporozoite protein is amplified by 3D substrate and correlates with protection, Cell Reports (Okada)
Activation of the Plasmodium Egress Effector Subtilisin-Like Protease 1 Is Mediated by Plasmepsin X Destruction of the Prodomain., mSphere (Quratul-ain)
230928
Development of Plasmodium falciparum liver-stages in hepatocytes derived from human fetal liver organoid cultures, Nature Communications (Shinzawa)
An ex vivo model of Toxoplasma recrudescence reveals developmental plasticity of the bradyzoite stage, mSphere (Baba)
231012
Zonal human hepatocytes are differentially permissive to Plasmodium falciparum malaria parasites, EMBO J (Sekine)
Plasmodium falciparum formins are essential for invasion and sexual stage development, Communications Biology (Tay)
231026
A Plasmodium falciparum ATP-binding cassette transporter is essential for liver stage entry into schizogony , iScience (Mark)
231116
Time-resolved proximity biotinylation implicates a porin protein in export of transmembrane malaria parasite effectors, Journal of Cell Science (Quratul-ain)
Massive horizontal gene transfer and the evolution of nematomorph-driven behavioral manipulation of mantids, Cell Press (Kumagai)