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Research Supporting the use of PRP in Foot and Ankle conditions
Foot - Plantar Fasciitis
In patients with chronic plantar fasciitis, the current clinical evidence suggests that PRP may lead to a greater improvement in pain and functional outcome over CS injections.
https://pubmed.ncbi.nlm.nih.gov/32426407/
Treatment of patients with chronic plantar fasciitis with PRP seems to reduce pain and increase function more as compared with the effect of corticosteroid injection.
https://www.ncbi.nlm.nih.gov/pubmed/31603721
PRP injections provide better pain relief, compared to corticosteroids, in patients with plantar fasciitis at 3 months and 6 months.
https://www.ncbi.nlm.nih.gov/pubmed/32336895#
PRP had statistically and clinically better improvement in long term pain when compared to corticosteroid injection for plantar fasciitis
https://www.ncbi.nlm.nih.gov/pubmed/31821010
PRP is superior to corticosteroid injections for pain control at 3 months and lasts up to 1 year.
https://pubmed.ncbi.nlm.nih.gov/32822236/
Treatment with HVI or PRP in combination with eccentric training in chronic AT seems more effective in reducing pain, improving activity level, and reducing tendon thickness and intratendinous vascularity than eccentric training alone
https://www.ncbi.nlm.nih.gov/pubmed/28530451
PRP and ESW represent both reliable solutions for plantar fasciitis leading to good results in terms of patients’ satisfaction, pain, and clinical outcomes. However, after treatment with PRP injections less recurrences in overall population and faster return to sporting activities in sports practitioners were observed.
https://www.sciencedirect.com/science/article/abs/pii/S106725162200299X
This study demonstrates that Platelet-Rich Plasma (PRP) treatment is a relatively safe and efficient treatment for chronic fasciitis compared to surgical intervention. In this current study, PRP demonstrated comparable pain reduction and functional outcomes with less potential complications, including response to physical therapy, that may arise with surgical intervention.
https://www.mdpi.com/2077-0383/11/23/6986
PRP had a statistically higher pain reduction than ESWT, but the difference does not reach clinical significance in this meta-analysis.
https://pubmed.ncbi.nlm.nih.gov/38419209/
The PRP injection showed better outcomes than steroid injection in plantar fasciitis treatment over the course of six months. Further research with a larger population and longer follow-up than six months is needed to generalize the findings and their long-term efficacy.
https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-023-06277-1
ANKLE
Ankle/foot - Achilles Tendinopathy
Both ESWT and PRP therapy are effective and safe. Our study confirms the success of these conservative treatments in Achilles tendinopathy, even in the insertional one.
https://pubmed.ncbi.nlm.nih.gov/28717617/
Ankle - Osteoarthritis
This meta-analysis supports the safety of PRP intra-articular injection for ankle OA. The improvements of AOFAS and VAS scores in the PRP group at short-term follow-up do not exceed the MCID to be clinically significant. PRP injection provides significant improvement of AOFAS score and reduced pain at ≥ six months follow-up. The efficacy of PRP should be interpreted with caution regarding the high heterogeneity and the scarcity of available literature, which urges large-scale RCTs with longer follow-up to confirm the potential efficacy of PRP injection for ankle OA.
https://pubmed.ncbi.nlm.nih.gov/36943456/
For patients with ankle osteoarthritis, PRP injections (Arthrex ACP, 15 cc, 2x platelet count compared to whole blood) did not improve ankle symptoms and function over 52 weeks compared with placebo injections.
https://pubmed.ncbi.nlm.nih.gov/37417359/
Ankle - High Ankle Sprain
Athletes suffering from high ankle sprains benefit from ultrasound-guided PRP injections with a shorter RTP, re-stabilization of the syndesmosis joint and less long-term residual pain.
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