biologic/regenerative medicine injections can be performed to treat foot and ankle conditions and is preferred over steroids due to the destructive effect of steroid on soft tissue and cartilage. More research is continually being conducted to study the benefits of these treatments 

• Treatment of patients with chronic plantar fasciitis with PRP seems to reduce pain and increase function more as compared with the effect of corticosteroid injection.

• PRP injections provide better pain relief, compared to corticosteroids, in patients with plantar fasciitis at 3 months and 6 months.

• PRP is superior to corticosteroid injections for pain control at 3 months and lasts up to 1 year.  

• Both ESWT and PRP therapy are effective and safe. Our study confirms the success of these conservative treatments in Achilles tendinopathy, even in the insertional one.

• PRP injection provides significant improvement of function score and reduced pain at ≥ six months follow-up. The efficacy of PRP should be interpreted with caution regarding the high heterogeneity and the scarcity of available literature.

• ACHILLES: Both ESWT and PRP therapy are effective and safe. Our study confirms the success of these conservative treatments in Achilles tendinopathy, even in the insertional one.

• ANKLE SPRAIN: Athletes suffering from high ankle sprains benefit from ultrasound-guided PRP injections with a shorter RTP, re-stabilization of the syndesmosis joint and less long-term residual pain.