RESEARCH
踏雪野中去 不須胡亂行
RESEARCH INTERESTS
Basic Science:
1. Protein arginine methyltransferases (PRMTs): the biological roles and their regulation mechanisms
- Identification and characterization of novel PRMT substrates
- Molecular function of epigenetic machinery: writers, erasers and readers
- Cross-talks between epigenetic marks
2. Cellular homeostasis via protein arginine methylation
- Cell cycle & Mitosis
- Mitochondrial homeostasis & energy metabolism
- Microtubule dynamics
- DNA damage response (DDR)
- Regulation of autophagy
Drug Development:
3. Discovery of epigenetic drugs from chemical library
- PR(K)MT inhibitors
- HDAC inhibitors and SIRT inhibitors (activators)
- Protein-protein interaction inhibitors
4. Novel strategies targeting multi-drug resistant cancer
- Development of P-gp non-substrate anticancer drugs from chemical library
- Combination therapies for the treatment of incurable cancer
- Tumor microenvironments and epigenetic regulation
