RESEARCH

Basic Science

🔊Protein arginine methylation

1. The biological roles and their regulation mechanisms

2. Molecular function of epigenetic machinery: writers, erasers and readers

3. Cross-talks between epigenetic marks

4. All cellular responses associated with arginine methylation

🔊Protein arginine methyltransferases (PRMTs)

1. Identification and characterization of novel PRMT substrates

2. Identification and characterization of Arginine demthylase

3. Cellular homeostasis via protein arginine methylation
   - Cell cycle & mitosis
   - Microtubule dynamics
   - Mitochondrial homeostasis
   - Energy metabolism
   - DNA damage response and genomic instability
   - Autophagy & ferroptosis

Drug Development

 🔉Discovery of epigenetic drugs from chemical library

1. PRMT inhibitors

2. HDAC/SIRT inhibitors

3. Protein-protein interaction inhibitors

🔉Novel strategies for treating intractable diseases 

1. Epigenetic interplay in intractable disease development 

2. Synthetic lethality for incurable cancer (including MDR cancer)

3. Healthy aging strategies targeting Redox homeostasis 

Our research is fully supported by funding from NRF and MSIT

Project No: RS-2025-00563180

• Mid-Career Researcher Grant (Mar 2025 - Feb 2030)

• Title: Dynamic Regulation of Mitochondrial Arginine Methylation: Its Involvement in Doxorubicin-Induced Cardiotoxicity

Project No: RS-2024-00509503

• Korea-EU Global Research Center (Oct 2024 - Dec 2026)

• Title: External Stimulus Responsible Gene Therapy Research Center

Project No: RS-2022-NR070845

• Medical Research Center (Jun 2022 - Feb 2029) 

• Title: Muscle Physiome Research Center
  
  

Project No: RS-2024-00412728 (to Yena Cho)

• NRF PhD Candidate Fellowship (Sep 2024 - Aug 2026)

• Title: The Regulation of Mitochondrial Dynamics through CARM1-DRP1 Axis