PUBLICATIONS
Research is an art written in the language of experiment
Research is an art written in the language of experiment
[2025]
Context-Specific Applications of CARM1 Inhibitors: Functional Profiles of EZM2302 and TP-064
Y Cho, YK Kim*
Molecular Medicine, 2025 (accepted) [6.4, 15.0%]
Multifaceted Roles of CARM1 Beyond Histone Arginine Methylation
Y Cho, YK Kim*
Experimental & Molecular Medicine, 2025 (accepted) [12.9, 4.2%]
Reversible arginine methylation of PI3KC2α controls mitotic spindle dynamics
Y Cho, JW Hwang, MT Bedford, DH Na, DG Song, SN Kim, YK Kim*
Cell Communication and Signaling, 2025; 23(1), 409 [8.9, 15.2%] [PDF]
CARM1 S217 phosphorylation by CDK1 in late G2 phase facilitates mitotic entry
Y Cho, DG Song, SN Kim, YK Kim*
Cell Death & Disease, 2025; 16 (1), 202 [8.1, 15.9%] [PDF]
CARM1 regulates tubulin autoregulation through PI3KC2α R175 methylation
Y Cho, JW Hwang, MT Bedford, DG Song, SN Kim, YK Kim*
Cell Communication and Signaling, 2025; 23 (1), 120 [8.2, 15.4%] [PDF]- 100th paper
[2024]
CARM1 phosphorylation at S595 by p38γ MAPK drives ROS-mediated cellular senescence
Y Cho, YK Kim*
Redox Biology, 2024; 76, 103344 [10.7, 5.3%] 🗞️SM NEWS, BRIC, 한겨레, 대학신문, 약사공론
Y Cho, YK Kim*
Redox Biology, 2024; 73, 103212 [10.7, 5.3%] 🗞️SM NEWS, BRIC, 대학신문, 데일리팜
Epsti1 Regulates the Inflammatory Stage of Early Muscle Regeneration through STAT1-VCP Interaction
JW Kim, JH Bae, GY Go, JR Lee, Y Jeong, JY Kim, TH Kim, YK Kim, JW Han, JE Oh, MJ Hahn*, JS Kang*, GU Bae*
International Journal of Biological Sciences, 2024; 20 (9), 3530-3543 [8.2, 9.7%]
[2023]
Y Cho, JW Hwang, NJ Park, J Moon, KH Ali, YH Seo, IS Kim*, SN Kim*, YK Kim*
Free Radical Biology and Medicine, 2023; 208, 73-87 [7.4, 11.0%] 🗞️숙약뉴스
SH Lee, Y Oh, SK Bong, JW Lee, NJ Park, YJ Kim, HB Park, YK Kim, SH Kim*, SN Kim*
Applied Biological Chemistry, 2023; 66 (1), 58 [3.2, 57.5%]
H Lee, S Ha, SG Choi, S Do, S Yoon, YK Kim, WY Kim*
International Journal of Molecular Sciences, 2023; 24 (11), 9530 [5.6, 20.9%]
[2022]
PRMT7 inhibitor SGC8158 enhances doxorubicin-induced DNA damage and its cytotoxicity
A Jeong, Y Cho, M Cho, GU Bae, DG Song, SN Kim*, YK Kim*
International Journal of Molecular Sciences, 2022; 23 (20), 12323 [5.6]
SK Bong, NJ Park, SH Lee, JW Lee, AT Kim, X Liu, SM Kim, MH Yang, MH Yang, YK Kim*, SN Kim*
International Journal of Molecular Sciences, 2022; 23 (17), 10163 [5.6]
NJ Park, BG Jo, SK Bong, S Park, S Lee, YK Kim, MH Yang*, SN Kim*
International Journal of Molecular Sciences, 2022; 23 (15), 8687 [5.6]
BY Ahn, MH Jeong, JH Pyun, HJ Jeong, TA Vuong, JH Bae, S An, SW Kim, YK Kim, D Ryu, HJ Kim, H Cho, GU Bae*, JS Kang*
Cellular and Molecular Life Sciences, 2022; 79 (2), 99 [9.2]
[2021]
M Park, JW Hwang, Y Cho, S Kim, SH Han, J Yu, S Ha, WY Kim, SN Kim, IS Kim*, YK Kim*
Scientific Reports, 2021; 11 (1), 10822 [5.0]
Protein arginine methyltransferases: promising targets for cancer therapy
JW Hwang, Y Cho, GU Bae, SN Kim, YK Kim*
Experimental & Molecular Medicine, 2021; 53 (5), 788-808 [8.7] 🗞️BRIC
[2020]
S Park, SK Bong, JW Lee, NJ Park, Y Choi, SM Kim, MH Yang, YK Kim, SN Kim*
Biomolecules & Therapeutics, 2020; 28 (6), 542 [4.6]
Compound K improves skin barrier function by increasing SPINK5 expression
NJ Park, SK Bong, S Lee, Y Jung, H Jegal, J Kim, SK Kim, YK Kim, SN Kim*
Journal of Ginseng Research, 2020; 44 (6), 799-807 [5.5]
JW Hwang, SN Kim, N Myung, D Song, G Han, GU Bae, MT Bedford*, YK Kim*
Communications Biology, 2020; 3 (1), 428 [4.2]
Cancer stem cells as a potential target to overcome multidrug resistance
Y Cho, YK Kim*
Frontiers in Oncology, 2020; 10, 764 [4.8]
GY Go, A Jo, DW Seo, WY Kim, YK Kim, EY So, Q Chen, JS Kang, GU Bae*, SJ Lee*
Journal of Ginseng Research, 2020; 44 (3), 435-441 [5.5]
PRMT6-mediated H3R2me2a guides Aurora B to chromosome arms for proper chromosome segregation
S Kim, NH Kim, JE Park, JW Hwang, N Myung, KT Hwang, YA Kim, CY Jang*, YK Kim*
Nature Communications, 2020; 11 (1), 612 [12.1] 🗞️SM NEWS, BRIC, 이데일리, 대학신문
-2019-
Lee S, Jegal H, Bong SK, Yoon KN, Park NJ, Shin M, Yang MH, Kim YK*, Kim SN*. Anti-atopic effect of arcon shell extract on atopic dermatitis-like lesions in mice and its active phytochemicals. Biomolecules. 2019 Dec 29;10(1). pii: E57. doi: 10.3390/biom10010057.
Hwang JW, So YS, Bae GU, Kim SN, Kim YK*. Protein arginine methyltransferase 6 suppresses adipogenic differentiation by repressing peroxisome proliferator‑activated receptor γ activity. Int J Mol Med. 2019 Jun;43(6):2462-2470.
Kim WJ, Lee W, Jung Y, Jang HJ, Kim YK*, Kim SN*. PPARβ/δ agonist GW501516 inhibits TNFα-induced repression of adiponectin and insulin receptor in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2019 Mar 19;510(4):621-628.
-2018-
Jung Y, Kim JC, Park NJ, Bong SK, Lee S, Jegal H, Jin LT, Kim SM, Kim YK, Kim SN. Eupatilin, an activator of PPARα, inhibits the development of oxazolone-induced atopic dermatitis symptoms in Balb/c mice. Biochem Biophys Res Commun. 2018 Feb 5;496(2):508-514.
Lee SY, Go GY, Vuong TA, Kim JW, Lee S, Jo A, An JM, Kim SN, Seo DW, Kim JS, Kim YK, Kang JS, Lee SJ, Bae GU. Black ginseng activates Akt signaling, thereby enhancing myoblast differentiation and myotube growth. J Ginseng Res. 2018 Jan;42(1):116-121.
-2017-
Jung Y, Kim JC, Choi Y, Lee S, Kang KS, Kim YK, Kim SN. Eupatilin with PPARα agonistic effects inhibits TNFα-induced MMP signaling in HaCaT cells. Biochem Biophys Res Commun. 2017 Nov 4;493(1):220-226.
Lee S, Lee DH, Kim JC, Um BH, Sung SH, Jeong LS, Kim YK, Kim SN. Pectolinarigenin, an aglycone of pectolinarin, has more potent inhibitory activities on melanogenesis than pectolinarin. Biochem Biophys Res Commun. 2017 Nov 4;493(1):765-772.
Go GY, Lee SJ, Jo A, Lee J, Seo DW, Kang JS, Kim SK, Kim SN, Kim YK, Bae GU. Ginsenoside Rg1 from Panax ginseng enhances myoblast differentiation and myotube growth. J Ginseng Res. 2017 Oct;41(4):608-614.
Lee SJ, Leem YE, Go GY, Choi Y, Song YJ, Kim I, Kim DY, Kim YK, Seo DW, Kang JS, Bae GU. Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts. PLoS One. 2017 Apr 6;12(4):e0175271.
Jung Y, Cao Y, Paudel S, Yoon G, Cheon SH, Bae GU, Jin LT, Kim YK, Kim SN. Antidiabetic effect of SN158 through PPARα/γ dual activation in ob/ob mice. Chem Biol Interact. 2017 Apr 25;268:24-30.
Kim JH, Kim MS, Lee BH, Kim JK, Ahn EK, Ko HJ, Cho YR, Lee SJ, Bae GU, Kim YK, Oh JS, Seo DW. Marmesin-mediated suppression of VEGF/VEGFR and integrin β1 expression: Its implication in non-small cell lung cancer cell responses and tumor angiogenesis. Oncol Rep. 2017 Jan;37(1):91-97.
-2016-
Lee SJ, Hwang J, Jeong HJ, Yoo M, Go GY, Lee JR, Leem YE, Park JW, Seo DW, Kim YK, Hahn MJ, Han JW, Kang JS, Bae GU. PKN2 and Cdo interact to activate AKT and promote myoblast differentiation. Cell Death Dis. 2016 Oct 20;7(10):e2431.
Yoo M, Lee SJ, Kim YK, Seo DW, Baek NI, Ryu JH, Kang JS, Bae GU. Dehydrocorydaline promotes myogenic differentiation via p38 MAPK activation. Mol Med Rep. 2016 Oct;14(4):3029-36.
Hwang JW, Cho H, Lee JY, Jeon Y, Kim SN, Lee SJ, Bae GU, Yoon S, Jeon R, Kim YK. The synthetic ajoene analog SPA3015 induces apoptotic cell death through crosstalk between NF-κB and PPARγ in multidrug-resistant cancer cells. Food Chem Toxicol. 2016 Oct;96:35-42.
Lee W, Yoon G, Kim MC, Kwon HC, Bae GU, Kim YK, Kim SN. 5,7-Dihydroxy-6-geranylflavanone improves insulin sensitivity through PPARα/γ dual activation. Int J Mol Med. 2016 May;37(5):1397-404.
Lee SJ, Yoo M, Go GY, Kim do H, Choi H, Leem YE, Kim YK, Seo DW, Ryu JH, Kang JS, Bae GU. Bakuchiol augments MyoD activation leading to enhanced myoblast differentiation. Chem Biol Interact. 2016 Mar 25;248:60-7.
Lee SJ, Go GY, Yoo M, Kim YK, Seo DW, Kang JS, Bae GU. Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) activates promyogenic signaling pathways, thereby promoting myoblast differentiation. Biochem Biophys Res Commun. 2016 Jan 29;470(1):157-62
-2015-
Kim JH, Kim JK, Ahn EK, Ko HJ, Cho YR, Lee CH, Kim YK, Bae GU, Oh JS, Seo DW. Marmesin is a novel angiogenesis inhibitor: Regulatory effect and molecular mechanism on endothelial cell fate and angiogenesis. Cancer Lett. 2015 Dec 28;369(2):323-30.
Yoo M, Kim BG, Lee SJ, Jeong HJ, Park JW, Seo DW, Kim YK, Lee HY, Han JW, Kang JS, Bae GU. Syntaxin 4 regulates the surface localization of a promyogenic receptor Cdo thereby promoting myogenic differentiation. Skelet Muscle. 2015 Sep 7;5:28.
Lee W, Ham J, Kwon HC, Yoon G, Bae GU, Kim YK, Kim SN. Amorphastilbol exerts beneficial effects on glucose and lipid metabolism in mice consuming a high-fat-diet. Int J Mol Med. 2015 Aug;36(2):527-33.
Kim JH, Kim HJ, Kim JK, Ahn EK, Ko HJ, Cho YR, Lee SJ, Bae GU, Kim YK, Park JW, Oh JS, Seo DW. Ligularia fischeri inhibits endothelial cell proliferation, invasion and tube formation through the inactivation of mitogenic signaling pathways and regulation of vascular endothelial cadherin distribution and matrix metalloproteinase expression. Oncol Rep. 2015 Jul;34(1):221-6.
Han KY, Hwang JW, Bae GU, Kim SN, Kim YK. Akt regulation of Aven contributes to the sensitivity of cancer cells to chemotherapeutic agents. Mol Med Rep. 2015 May;11(5):3866-71.
Jeon Y, Jung Y, Youm JK, Kang KS, Kim YK, Kim SN. Abietic acid inhibits UVB-induced MMP-1 expression in human dermal fibroblast cells through PPARα/γ dual activation. Exp Dermatol. 2015 Feb;24(2):140-5.
Hwang J, Lee SJ, Yoo M, Go GY, Lee DY, Kim YK, Seo DW, Kang JS, Ryu JH, Bae GU. Kazinol-P from Broussonetia kazinoki enhances skeletal muscle differentiation via p38MAPK and MyoD. Biochem Biophys Res Commun. 2015 Jan 2;456(1):471-5.
-2014-
Lee SJ, Yoo M, Go GY, Hwang J, Lee HG, Kim YK, Seo DW, Baek NI, Ryu JH, Kang JS, Bae GU. Tetrahydropalmatine promotes myoblast differentiation through activation of p38MAPK and MyoD. Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):147-52.
Cho YR, Kim JH, Kim JK, Ahn EK, Ko HJ, In JK, Lee SJ, Bae GU, Kim YK, Oh JS, Seo DW. Broussonetia kazinoki modulates the expression of VEGFR-2 and MMP-2 through the inhibition of ERK, Akt and p70S6K‑dependent signaling pathways: Its implication in endothelial cell proliferation, migration and tubular formation. Oncol Rep. 2014 Oct;32(4):1531-6.
Jeon Y, Jung Y, Kim MC, Kwon HC, Kang KS, Kim YK*, Kim SN*. Sargahydroquinoic acid inhibits TNFα-induced AP-1 and NF-κB signaling in HaCaT cells through PPARα activation. Biochem Biophys Res Commun. 2014 Aug 8;450(4):1553-9
-2013-
Kim NH*, Kim SN, Seo Dw, Han JW, Kim YK*. PRMT6 overexpression upregulates TSP-1 and downregulates MMPs: its implication in motility and invasion of cencer cells. Biochem Biophys Res Commun. 2013. Mar 1;432(1):60-5.
Lee W, Ham J, Kwon HC, Kim YK*, Kim SN*. Anti-diabetic effect of amorphastilbol through PPARa/g dual activation in db/db mice. Biochem Biophys Res Commun. 2013 Mar 1;432(1):73-9.
-2012-
Lee W, Eom DW, Jung Y, Yamabe N, Lee S, Jeon Y, Hwang YR, Lee, JH, Kim YK, Kang KS, Kim SN . Dendrobium moniliforme Attenuates High-Fat Diet-Induced Renal Damage in Mice through the Regulation of Lipid-Induced Oxidative Stress. Am J Chin Med. 2012 Dec;40(6):1217-28.
Kim SH, Cho YR, Lee SJ, Wei BY, Kim YK, Stetler-Stevenson WG, Seo DW. Antagonism of VEGF-A-induced increase in vascular permeability by an integrin α3β1-Shp-1-cAMP/PKA pathway. Blood. 2012 Dec 07;120(24), 4892-902.
Lee W, Yoon G, Jung Y, Jeon Y, Hwang YR, Kang KS, Kim YK, Um SH, Kim SN. Dendrobium moniliforme extract regulates glucose and lipid metabolism through activation of peroxisome proliferator-activated receptor α. JMPR. 2012 Oct 25;6(41):5452-59.
Jeong KJ, Park SY, Cho KH, Sohn JS, Lee J, Kim YK, Kang J, Park CG, Han JW, Lee HY. The Rho/ROCK pathway for lysophosphatidic acid-induced proteolytic enzyme expression and ovarian cancer cell invasion. Oncogene. 2012 Sep 27;31(39):4279-89.
Kim SN, Lee W, Bae GU, Kim YK. Anti-diabetic and hypolipidemic effects of Sargassum yezoense in db/db mice. Biochem Biophys Res Commun. 2012 Aug;424(4):675-680.
Lee W, Yoon G, Hwang YR, Kim YK, Kim SN. Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition. BMB Rep. 2012 Mar;45(3):141-6.
Kim NH, Kim SN, Oh JS, Lee S, Kim YK. Anti-mitotic potential of 7-diethylamino-3(2'-benzoxazolyl)-coumarin in 5-fluorouracil-resistant human gastric cancer cell line SNU620/5-FU. Biochem Biophys Res Commun. 2012 Feb 24;418(2):616-21.
-2011-
Cha B, Kim W, Kim YK, Hwang BN, Park SY, Yoon JW, Park WS, Cho JW, Bedford MT, Jho EH. Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling. Oncogene. 2011 May 19;30(20):2379-89.
Spannhoff A, Kim YK, Raynal NJ, Gharibyan V, Su MB, Zhou YY, Li J, Castellano S, Sbardella G, Issa JP, Bedford MT. Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees. EMBO Rep. 2011 Mar;12(3):238-43.
Park SY, Kang JH, Jeong KJ, Lee J, Han JW, Choi WS, Kim YK, Kang J, Park CG, Lee HY. Norepinephrine induces VEGF expression and angiogenesis by a hypoxia-inducible factor-1α protein-dependent mechanism. Int J Cancer. 2011 May 01; 128(10):2306-16.
Kim H, Kim SN, Park YS, Kim NH, Han JW, Lee HY, Kim YK. HDAC inhibitors downregulate MRP2 expression in multidrug resistant cancer cells: Implication for chemosensitization. Int J Oncol. 2011 Mar;38(3):807-12.
Kim NH, Kim SN, Kim YK. Involvement of HDAC1 in E-cadherin expression in prostate cancer cells; its implication for cell motility and invasion. Biochem Biophys Res Commun. 2011 Jan 28;404(4):915-21.
-2010-
Seo JH, Jeong KJ, Oh WJ, Sul HJ, Sohn JS, Kim YK, Cho do Y, Kang JK, Park CG, Lee HY. Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: their inhibition by curcumin. Cancer Lett. 2010 Feb 1;288(1):50-6.
-2009-
Kim SN, Kim NH, Lee W, Seo DW, Kim YK. Histone deacetylase inhibitor induction of P-glycoprotein transcription requires both histone deacetylase 1 dissociation and recruitment of CAAT/enhancer binding protein beta and pCAF to the promoter region. Mol Cancer Res. 2009 May;7(5):735-44.
Kim SN, Kim NH, Park YS, Kim H, Lee S, Wang Q, Kim YK. 7-Diethylamino-3(2'-benzoxazolyl)-coumarin is a novel microtubule inhibitor with antimitotic activity in multidrug resistant cancer cells. Biochem Pharmacol. 2009 Jun 15;77(12):1773-9.
Kim SN, Choi HY, Kim YK. Regulation of adipocyte differentiation by histone deacetylase inhibitors. Arch Pharm Res. 2009 Apr;32(4):535-41.
Lee EK, Bae GU, You JS, Lee JC, Jeon YJ, Park JW, Park JH, Ahn SH, Kim YK, Choi WS, Kang JS, Han G, Han JW. Reversine increases the plasticity of lineage-committed cells toward neuroectodermal lineage. J Biol Chem. 2009 Jan 30;284(5):2891-901.
-2008-
Jeong KJ, Park SY, Seo JH, Lee KB, Choi WS, Han JW, Kang JK, Park CG, Kim YK, Lee HY. Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells. Exp Mol Med. 2008 Dec 31;40(6):607-16.
Kim SN, Choi HY, Lee W, Park GM, Shin WS, Kim YK. Sargaquinoic acid and sargahydroquinoic acid from Sargassum yezoense stimulate adipocyte differentiation through PPARalpha/gamma activation in 3T3-L1 cells. FEBS Lett. 2008 Oct 15;582(23-24):3465-72.
Seo DW, Kim SH, Eom SH, Yoon HJ, Cho YR, Kim PH, Kim YK, Han JW, Diaz T, Wei BY, Stetler-Stevenson WG. TIMP-2 disrupts FGF-2-induced downstream signaling pathways. Microvasc Res. 2008 Nov;76(3):145-51.
Lee JH, Kim JW, Ko NY, Mun SH, Kim DK, Kim JD, Kim HS, Lee KR, Kim YK, Radinger M, Her E, Choi WS. Camellia japonica suppresses immunoglobulin E-mediated allergic response by the inhibition of Syk kinase activation in mast cells. Clin Exp Allergy. 2008 May;38(5):794-804.
Um Y, Cho S, Woo HB, Kim YK, Kim H, Ham J, Kim SN, Ahn CM, Lee S. Synthesis of curcumin mimics with multidrug resistance reversal activities. Bioorg Med Chem. 2008 Apr 1;16(7):3608-15.
Kim YK, Kim NH, Hwang JW, Song YJ, Park YS, Seo DW, Lee HY, Choi WS, Han JW, Kim SN. Histone deacetylase inhibitor apicidin-mediated drug resistance: involvement of P-glycoprotein. Biochem Biophys Res Commun. 2008 Apr 18;368(4):959-64.
-2007-
Park SY, Jeong KJ, Lee J, Yoon DS, Choi WS, Kim YK, Han JW, Kim YM, Kim BK, Lee HY. Hypoxia enhances LPA-induced HIF-1alpha and VEGF expression: Their inhibition by resveratrol. Cancer Lett 2007 Dec 8;258(1):63-9.
Kim YK. TGF-beta1 induction of p21WAF1/Cip1 requires smad-independent protein kinase C signaling pathway. Arch Pharm Res. 2007 Jun;30(6):739-42.
Kim YK, Choi HY, Kim NH, Lee W, Seo DW, Kang DW, Lee HY, Han JW, Park SW, Kim SN. Reversine stimulates adipocyte differentiation and downregulates Akt and p70S6K signaling pathways in 3T3-L1 cells. Biochem Biophys Res Commun 2007 Jun 29;358(2):553-8.
Chun JK, Seo DW, Ahn SH, Park JH, You JS, Lee CH, Lee JC, Kim YK, Han JW. Suppression of the NF-kB Signaling Pathway by Ergolide, Sesquiterpene Lactone, in HeLa cells. J Pharm Pharmacol 2007 Apr;59(4):561-6.
Kim YK, Song YJ, Seo DW, Kang DW, Lee HY, Rhee DK, Han JW, Ahn CM, Lee S, Kim SN. Reversal of multidrug resistance by 4-chloro-N-(3-((E)-3-(4-hydroxy-3-methoxyphenyl) acryloyl)phenyl)benzamide through the reversible inhibition of P-glycoprotein. Biochem Biophys Res Commun 2007 Mar 30;355(1):136-42.
Kang JK, Park KW, Chung YG, You JS, Kim YK, Lee SH, Hong SP, Choi KM, Heo KN, Seol JG, Lee JH, Jin DI, Park CS, Seo JS, Lee HW, Han JW. Coordinated Change of a Ratio of Methylated H3-lysine 4 or Acetylated H3 to Acetylated H4 and DNA Methylation Is Associated with Tissue-Specific Gene Expression in Cloned Pig. Exp Mol Med 2007 Feb 28; 39(1):84-96.
-2006-
Kim YK, Lee EK, Kang JK, Kim JA, You JS, Park JH, Seo DW, Hwang JW, Kim SN, Lee HY, Lee HW, Han JW. Activation of NF-kB by HDAC inhibitor apicidin through Sp1-dependent de novo protein synthesis: its implication for resistance to apoptosis. Cell Death & Differentiation 2006 Dec 1;13:2033-41.
Lee J, Park SY, Lee EK, Park CG, Chung HC, Rha SY, Kim YK, Bae GU, Kim BK, Han JW, Lee HY. Activation of Hypoxia-Inducible Factor-1α Is Necessary for Lysophosphatidic Acid–Induced Vascular Endothelial Growth Factor Expression. Clinical Cancer Research 2006 Nov 1;12(21):6351-6358.
Kim YK, Seo DW, Kang DW, Lee HY, Han JW, Kim SN. Involvement of HDAC1 and the PI3K/PKC signaling pathways in NF-kB activation by the HDAC inhibitor apicidin. Biochem Biophys Res Commun 2006 Sep 8;347(4):1088-93.
Joe MJ, Kim SN, Choi HY, Shin WS, Park GM, Kang DW, Kim YK. The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts. Biol Pharm Bull 2006 Aug;29(8):1735-9.
Kim S, Kang JK, Kim YK, Seo DW, Ahn SH, Lee JC, Lee CH, You JS, Cho EJ, Lee HW, Han JW. Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites. Biochem Biophys Res Commun 2006 Apr 21;342(4):1168-73.
Kim YK, Bae GU, Kang JK, Park JW, Lee EK, Lee HY, Choi WS, Lee HW, Han JW. Cooperation of H2O2-mediated ERK activation with Smad pathway in TGF- β1 induction of p21WAF1/Cip1. Cellular Signalling 2006 Feb;18(2):236-43.
-2005-
Song YJ, Lee DY, Kim SN, Lee KR, Lee HW, Han JW, Kang DW, Lee HY, Kim YK. Apoptotic potential of sesquiterpene lactone ergolide through the inhibition of NF-kB signaling pathway. J Pharm Pharmacol 2005 Dec;57(12):1591-7.
Yoon JW, Kang JK, Lee KR, Lee HW, Han JW, Seo DW, Kim YK. β-Carboline alkaloid suppresses NF-kB transcriptional activity through inhibition of IKK signaling pathway. J Toxicol Environ Health A 2005 Dec; 68:2005-17.
Lee J, Jung ID, Chang WK, Park CG, Cho DY, Shin EY, Seo DW, Kim YK, Lee HW, Han JW, Lee HY. p85 β-PIX is required for cell motility through phosphorylations of focal adhesion kinase and p38 MAP kinase. Exp Cell Res. 2005 Jul 15;307(2):315-28.
-2004-
Bae GU*, Kim YK*, Kwon HK, Park JW, Lee EK, Paek SJ, Choi WS, Jung ID, Lee HY, Cho EJ, Lee HW, Han JW. Hydrogen peroxide mediates Rac1 activation of S6K1. Exp Cell Res. 2004 Nov 1;300(2):476-84. (*equally contributed to this work)
Jung ID, Lee J, Lee KB, Park CG, Kim YK, Seo DW, Park D, Lee HW, Han JW, Lee HY. Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells. Eur J Biochem. 2004 Apr;271(8):1557-65.
-2003-
Kim YK, Han JW, Woo YN, Chun JK, Yoo JY, Cho EJ, Hong S, Lee HY, Lee YW, Lee HW. Expression of p21WAF1/Cip1 through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKCepsilon signaling pathway. Oncogene 2003 Sep 4;22(38):6023-31.
Jung DK, Bae GU, Kim YK, Han SH, Choi WS, Kang H, Seo DW, Lee HY, Cho EJ, Lee HW, Han JW. Hydrogen peroxide mediates arsenite activation of p70S6K and extracellular signal-regulated kinase. Exp Cell Res. 2003 Oct 15;290(1):144-54.
Hong I*, Kim YK*, Choi WS, Seo DW, Yoon JW, Han JW, Lee HY, Lee HW. Purification and characterization of nitric oxide synthase from Staphylococcus aureus. FEMS Microbiol Lett. 2003 May 28;222(2):177-82. (*equally contributed to this work)
-2002-
Kwon HK, Bae GU, Yoon JW, Kim YK, Lee HY, Lee HW, Han JW. Constitutive activation of p70S6K in cancer cells. Arch Pharm Res. 2002 Oct;25(5):685-90.
Seo DW, Kim YK, Cho EJ, Han JW, Lee HY, Hong S, Lee HW. Oligosaccharide-linked acyl carrier protein, a novel transmethylase inhibitor, from porcine liver inhibits cell growth. Arch Pharm Res. 2002 Aug;25(4):463-8.
Lee HY, Bae GU, Jung ID, Lee JS, Kim YK, Noh SH, Stracke ML, Park CG, Lee HW, Han JW. Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells. FEBS Lett. 2002 Mar 27;515(1-3):137-40.
Kwon SH, Ahn SH, Kim YK, Bae GU, Yoon JW, Hong S, Lee HY, Lee YW, Lee HW, Han JW. Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells. J Biol Chem. 2002 Jan 18;277(3): 2073-80.
-2001-
Han JW, Ahn SH, Kim YK, Bae GU, Yoon JW, Hong S, Lee HY, Lee YW, Lee HW. Activation of p21(WAF1/Cip1) Transcription through Sp1 Sites by Histone Deacetylase Inhibitor Apicidin. J Biol Chem. 2001 Nov 9;276(45): 42084-90.
Han JW, Lee BG, Kim YK, Yoon JW, Jin HK, Hong S, Lee HY, Lee KR, Lee HW. Ergolide, sesquiterpene lactone from Inula britannica, inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-kB. Br J Pharmacol. 2001 Jun;133(4): 503-12.
Kim EJ, Jin HK, Kim YK, Lee HY, Lee SY, Lee KR, Zee OP, Han JW, Lee HW. Suppression by the sesquiterpene lactone from Carpesium divaricatum of inducible nitric oxide synthase by inhibiting NF-kB activation. Biochem Pharmacol. 2001 Apr 1;61(7):903-10.
Kim YM, Ahn SH, Seo DW, Kim YK, Han JW, Hong S, Kim S, Paik WK, Lee HW. Purification and Characterization of Protein Methylase II from Helicobacter pylori. FEMS Microbiol Lett. 2001 Feb 5;195(1):53-8.