LAB MEMBERS
啐啄同時
啐啄同時
MS-PhD course: 2022.03 ~
Research Associate: 2020.01 ~ 2022.02
PRMT regulation of cellular homeostasis:
- Mitochondrial dynamics and energy homeostasis
- Cell cycle & mitosis
- Microtubule dynamics
Selected Publications:
- CARM1 phosphorylation at S595 by p38γ MAPK drives ROS-mediated cellular senescence. Redox Biol. 2024, 76:103344
- ROS-mediated cytoplasmic localization of CARM1 induces mitochondrial fission through DRP1 methylation. Redox Biol. 2024, 73:103212
- CARM1 regulates tubulin autoregulation through PI3KC2α R175 methylation. Cell Commun Signal. 2025, 23:120
Reversible Arginine Methylation of PI3KC2α Controls Mitotic Spindle Dynamics
Y Cho, JW Hwang, MT Bedford, DH Na, DG Song, SN Kim, YK Kim*
Cell Communication and Signaling, 2025 (accepted) [8.9, 15.2%]
Multifaceted Roles of CARM1 Beyond Histone Arginine Methylation
Y Cho, YK Kim*
Experimental & Molecular Medicine, 2025 (accepted) [12.9, 4.2%]
CARM1 S217 phosphorylation by CDK1 in late G2 phase facilitates mitotic entry
Y Cho, DG Song, SN Kim, YK Kim*
Cell Death & Disease, 2025; 16 (1), 202 [8.1, 15.9%]
CARM1 regulates tubulin autoregulation through PI3KC2α R175 methylation
Y Cho, JW Hwang, MT Bedford, DG Song, SN Kim, YK Kim*
Cell Communication and Signaling, 2025; 23 (1), 120 [8.2, 15.4%]
CARM1 phosphorylation at S595 by p38γ MAPK drives ROS-mediated cellular senescence
Y Cho, YK Kim*
Redox Biology, 2024; 76, 103344 [10.7, 5.3%] 🗞️SM NEWS, BRIC, 한겨레, 대학신문, 약사공론
ROS-mediated cytoplasmic localization of CARM1 induces mitochondrial fission through DRP1 methylation
Y Cho, YK Kim*
Redox Biology, 2024; 73, 103212 [10.7, 5.3%] 🗞️SM NEWS, BRIC, 대학신문, 데일리팜
SPC-180002, a SIRT1/3 dual inhibitor, impairs mitochondrial function and redox homeostasis and represents an antitumor activity
Y Cho, JW Hwang, NJ Park, J Moon, KH Ali, YH Seo, IS Kim*, SN Kim*, YK Kim*
Free Radical Biology and Medicine, 2023; 208, 73-87 [7.4, 11.0%] 🗞️숙약뉴스
PRMT7 inhibitor SGC8158 enhances doxorubicin-induced DNA damage and its cytotoxicity
A Jeong, Y Cho, M Cho, GU Bae, DG Song, SN Kim*, YK Kim*
International Journal of Molecular Sciences, 2022; 23 (20), 12323 [5.6, 20.9%]
A novel synthetic microtubule inhibitor exerts antiproliferative effects in multidrug resistant cancer cells and cancer stem cells
M Park, JW Hwang, Y Cho, S Kim, SH Han, J Yu, S Ha, WY Kim, SN Kim, IS Kim*, YK Kim*
Scientific Reports, 2021; 11 (1), 10822 [4.997, 19.3%]
Protein arginine methyltransferases: promising targets for cancer therapy
JW Hwang, Y Cho, GU Bae, SN Kim, YK Kim*
Experimental & Molecular Medicine, 2021; 53 (5), 788-808 [8.718, 5.4%] 🗞️BRIC
Cancer stem cells as a potential target to overcome multidrug resistance
Y Cho, YK Kim*
Frontiers in Oncology, 2020; 10, 764 [4.848, 33.1%]
MS course: 2025.03 ~
PRMT regulation of cellular homeostasis
- PRMT inhibitors
Experimental Languages:
- Cell culture, MTT assay, Western blot, RT-qPCR etc
Intern: 2025.01 ~ 08
MS course: 2025.09 ~
PRMT regulation of cellular homeostasis:
- Energy homeostasis
- Autophagy
Experimental Languages:
- Cell culture, MTT assay, Western blot, RT-qPCR etc
Intern: 2024.03 ~
A novel strategy for treating intractable diseases
- RIOK1 inhibitors
- Drug repositioning
Experimental Languages:
- Cell culture, MTT assay, Western blot, RT-qPCR etc
Intern: 2025.08 ~
A novel strategy for treating intractable diseases
- RIOK1 inhibitors
- Drug repositioning
Experimental Languages:
- Cell culture, MTT assay, Western blot, RT-qPCR etc
MS 2021.03 ~ 2023.02
Current Position: Arum Therapeutics (2023.07 ~)
Dissertation: PRMT7 inhibitor SGC8158 enhances doxorubicin-induced DNA damage and its cytotoxicity.
Research: PRMT7 & DNA damage response
Publication: IJMS
PhD 2012.03 ~ 2017.08
Research Professor: 2017.09 ~ 2021.08
Current Position: PostDoc. MD Anderson Cancer Center (Dr. Santos Lab, 2021.08 ~)
Dissertation: Regulation of PRMT5 activity by tyrosine phosphorylation: Its involvement of DNA repair process
Research: regulation of genomic instability and cellular homeostasis by PRMTs
Publications: Nat Commun, Commun Biol etc
MS 2017.09 ~ 2020.02
Research Associate: 2020.03 ~ 2020.08
Current Position: PhD course, Graduate school, Hanyang University Molecular Life Science
Dissertation: Anti-proliferative effect of the substituted chromone on multidrug resistant cancer cells
Research: novel strategies to overcome MDR cancer: 5-(N-methylmaleimid-3-yl)-chromone
Publication: Sci Rep
MS 2015.03 ~ 2017.02
Research Associate: 2017.03 ~ 2017.08
Current Position: SK Bioscience -> Handok
Dissertation: Regulation of cell cycle progression and cell growth by CARM1
Research: regulation mechanisms of PRMTs: their implication in genomic instability and cellular homeostasis
Publication: Nat Commun, Commun Biol
MS 2013.03 ~ 2015.02
Current Position: SAMSUNG Bioepis
Dissertation: Negative regulation of PPARγ transcriptional activity by protein arginine methyltransferase 6
Research: regulation mechanisms of PRMTs: their implication in cellular homeostasis
Publication: Int J Mol Med
MS 2012.03 ~ 2014.02
Current Position: Community Pharmacy, Seoul
Dissertation: Expression of PRMT5 on the response to hypoxia
Research: regulation mechanisms of PRMTs: their implication in cellular homeostasis
2011.10 ~ 2014.08
Current Position:
Research: regulation mechanisms of PRMTs: their implication in cellular homeostasis
Publication: Mol Med Rep
2012.03 ~ 2013.02
Current Position:
Research: regulation mechanisms of PRMTs: their implication in cellular homeostasis
Intern: 2025.01 ~ 2025.04
A novel strategy for treating intractable diseases
- Drug repositioning
Experimental Languages:
- Cell culture, MTT assay, Western blot, RT-qPCR etc
MS course: 2024.02 ~ 06, leave of absence
from Inje University
Experimental Language:
- Cell culture, MTT assay, Western blot, RT-qPCR etc
Intern: 2023.08 ~ 2024.02
from Division of Biological Sciences, Sookmyung Women's Univ
Experimental Language: Cell culture, MTT assay, Western blot, RT-qPCR etc
A novel strategy for the treatment of incurable disease (RIOK1 inhibitors and H2 blockers)
MS course 2022.03 ~ 06, leave of absence
Internship: 2018.07 ~ 2018.12
Current Position: KOEDC
Biological roles of protein arginine methylation:
- ID and characterization of novel PRMT substrates
SW Kwon 22.12~23.05 Internship (22.12.19~23.05.31)
YW Na 22.12~23.02 Internship (22.12.19~23.02.24)
SJ Choi, PharmD 22.08~22.10 APPE (22.08.01~22.10.07)
JY Han 22.07~22.08 Internship (from Department of Biology Science, Chosun University)
MK Cho 22.01~23.05 Internship (22.01.01~22.2.28, 22.07.01~23.05.31]: DNA damage response and PRMTs
JH Lee 22.01~22.02 Internship (from Department of Integrative Bioscience and Biotechnology, KKU)
HJ Kwon, PharmD 21.07~23.03 Internship, Research Associate, APPE (22.12.26~23.03.03): Regulation of Autophagy by PRMTs
YH Kim, PharmD 21.07~21.08 Internship (22.01~22.02)
SM Kim, PharmD 21.01~21.02 InternshipㅣHospital Pharmacy, Seoul
SJ Hong, PharmD 21.01~21.02 Internship
Y Hong, PharmD 21.06~21.08 APPEㅣHospital Pharmacy, Seoul
YI Kim, PharmD 20.07~20.12 Internship
Y Cho, PharmD 20.01~22.02 Internship, Research Associate, APPEㅣSMWU graduate school (22.03~)
SY Jang, PharmD 19.01~19.06 InternshipㅣSNU graduate school (MS, 21.03~23.02)ㅣWhan In Pharm Co.,Ltd.
HK Seon, PharmD 18.01~18.02 InternshipㅣHospital Pharmacy, Seoul
YS Kim, PharmD 18.07~18.12 InternshipㅣHospital Pharmacy, SeoulㅣSMWU graduate school (22.03~05)
SK Lee, PharmD 17.07~17.08 InternshipㅣHospital Pharmacy, Seoul
TK Lee, PharmD 17.07~17.08 InternshipㅣHospital Pharmacy, Seoul
YJ Seon, PharmD 13.07~13.08 Internship
YY Jin, PharmD 12.07~12.08 Internship
JY Lee, PharmD 12.07~13.02 InternshipㅣSKKU graduate school (MS, 15.03~17.02)
SJ Kim, PharmD 12.01~13.02 InternshipㅣCRO company, UKㅣUCL graduate school, UK