LEAP into Science with ME

We focus on the understanding of cellular homeostasis and life phenomena through epigenetic research. Our primary goal is to unravel the intricate mechanisms underlying intracellular signaling networks and transcriptional regulatory machinery, with a specific focus on protein arginine methylation.  By unraveling these mechanisms, we aim to deepen our understanding of essential life phenomena and pave the way for the discovery of first-in class drugs . The number 15 holds special significance for us, representing the molecular weight of the methyl group—a core of our research. In our laboratory, we cultivate an environment that nurtures innovative thinking and encourages the participation of open-minded researchers who are driven to explore the profound value of independent life.

• Protein arginine methyltransferases: the biological roles and their regulation mechanism
  - Identification and characterization of novel PRMT substrates
  - Molecular function of epigenetic machinery: writers, erasers and readers
  - Cross-talks between epigenetic marks
  - Development of novel epigenetic inhibitors; their molecular mechanisms

• Cellular homeostasis via protein arginine methylation
  - Mitochondrial dynamics & energy  homeostasis
  - Microtubule dynamics
  - Cell cycle & Mitosis
  - Combination therapies for the treatment of incurable cancer  

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