研究業績
原著論文（査読有り）責任著者の場合は＊を付した。
1. Shigeru Saito*, Claire T Saito, Takeshi Igawa, Nodoka Takeda, Shohei Komaki, Toshio Ohta, and Makoto Tominaga
｢Evolutionary tuning of transient receptor potential ankyrin 1 underlies the variation in heat avoidance behaviors among frog species inhabiting diverse thermal niches｣
Molecular Biology and Evolution, 39: msac180 (2022)
2. A Yoshimura, S Saito*, C T Saito, K Takahashi, M Tominaga, and T Ohta
｢Functional analysis of thermo-sensitive TRPV1 in an aquatic vertebrate, masu salmon (Oncorhynchus masou ishikawae )｣
Biochemistry and Biophysics Reports 31: 101315 (2022)
3. Takeshi Yokoyama, Shigeru Saito, Misato Shimoda, Masakazu Kobayashi, Yoko Takasu, Hideki Sezutsu, Yoshiomi Kato, Makoto Tominaga, Akira Mizoguchi, and Kunihiro Shiomi
｢Comparisons in temperature and photoperiodic-dependent diapause induction between domestic and wild mulberry silkworms｣
Scientific Reports 11:805 (2021)
4. Kohei Ohnishi, Shigeru Saito, Toru Miura, Akane Ohta, Makoto Tominaga, Takaaki Sokabe, and Atsushi Kuhara
｢OSM-9 and OCR-2 TRPV channels are accessorial warm receptors in Caenorhabditis elegans temperature acclimatisation｣
Scientific Reports 10:18566 (2020)
5. Shohei Komaki, Yoichi Sutoh, Kensuke Kobayashi, Shigeru Saito, Claire T. Saito, Takeshi Igawa, and Quintin Lau
｢Hot spring frogs (Buergeria japonica) prefer cooler water to hot water｣
Ecology and Evolution 17:9466-9473 (2020)
6. R Uzura, K Takahashi, S Saito, M Tominaga, and T Ohta
｢Reduction of extracellular sodium evokes nociceptive behaviors in the chicken via activation of TRPV1｣
Brain Research 1747:147052 (2020)
7. Tianbang Li, Claire T. Saito, Tomoyuki Hikitsuchi, Yoshihiro Inoguchi, Honami Mitsuishi, Shigeru Saito* and Makoto Tominaga
｢Diverse sensitivities of TRPA1 from different mosquito species to thermal and chemical stimuli｣
Scientific Reports 9:20200 (2019)
8. Shigeru Saito*, Claire T. Saito, Masafumi Nozawa, and Makoto Tominaga
｢Elucidating the functional evolution of heat sensors among Xenopus species adapted to different thermal niches by ancestral sequence reconstruction｣
Molecular Ecology 28:3561-3571 (2019)
9. Hiroshi D. Akashi, Shigeru Saito, Antonio Cádiz Díaz, Takashi Makino, Makoto Tominaga, and Masakado Kawata
｢Comparisons of behavioural and TRPA1 heat sensitivities in three sympatric Cuban Anolis lizards｣
Molecular Ecology 27:2234–2242 (2018)
10. Azusa Majikina, Kenji Takahashi, Shigeru Saito, Makoto Tominaga, and Toshio Ohta
｢Involvement of nociceptive transient receptor potential channels in repellent action of pulegone｣
Biochemical Pharmacology 151:89-95 (2018)
11. Shigeru Saito, Gen Hamanaka, Narudo Kawai, Ryohei Furukawa, Jun Gojobori, Makoto Tominaga, Hiroyuki Kaneko, and Yoko Satta
｢Characterization of TRPA channels in the starfish Patiria pectinifera: involvement of thermally activated TRPA1 in thermotaxis in marine planktonic larvae｣
Scientific Reports 7:2173 (2017)
12. Erkin Kurganov, Shigeru Saito, Claire T. Saito, and Makoto Tominaga
｢Requirement of extracellular Ca2+ binding to specific amino acids for heat-evoked activation of TRPA1｣
The Journal of Physiology 595: 2451-2463 (2017)
13. Rupali Gupta, Shigeru Saito*, Yoshiharu Mori, Satoru G. Itoh, Hisashi Okumura, and Makoto Tominaga
｢Structural basis of TRPA1 inhibition by HC-030031 utilizing species-specific differences｣
Scientific Reports 6: 37460 (2016)
14. Yamamoto A., Takahashi K., Saito S., Tominaga M., and Ohta T
｢Two different avian cold-sensitive sensory neurons: Transient receptor potential melastatin 8 (TRPM8)-dependent and -independent activation mechanisms｣
Neuropharmacology 111:130-141 (2016)
15. Shigeru Saito*, Masashi Ohkita, Claire T. Saito, Kenji Takahashi, Makoto Tominaga, and Toshio Ohta
｢Evolution of Heat Sensors Drove Shifts in Thermosensation between Xenopus Species Adapted to Different Thermal Niches｣
The Journal of Biological Chemistry 291:11446-11459 (2016)
16. Ryohei Yatsu, Shinichi Miyagawa, Satomi Kohno, Shigeru Saito, Russell H. Lowers, Yukiko Ogino, Naomi Fukuta, Yoshinao Katsu, Yasuhiko Ohta, Makoto Tominaga, Louis J. Guillette Jr, and Taisen Iguchi
｢TRPV4 associates environmental temperature and sex determination in the American alligator｣
Scientific Reports 5: 18581 (2015)
17. Nagako Banzawa, Shigeru Saito, Toshiaki Imagawa, Makiko Kashio, Kenji Takahashi, Makoto Tominaga, and Toshio Ohta
｢Molecular Basis Determining Inhibition/Activation of Nociceptive Receptor TRPA1: A Single Amino Acid Dictates Species-specific Actions of the Most Potent Mammalian TRPA1 Antagonists｣
The Journal of Biological Chemistry 298:31927-31939 (2014)
18. Erkin Kurganov, Yiming Zhou, Shigeru Saito, and Makoto Tominaga
｢Heat and AITC Activate Green Anole TRPA1 in a Membrane-Delimited Manner｣
Pflügers Archiv - European Journal of Physiology 466: 1873-1884 (2014)
19. Shigeru Saito*, Nagako Banzawa, Naomi Fukuta, Claire T. Saito, Kenji Takahashi, Toshiaki Imagawa, Toshio Ohta, and Makoto Tominaga
｢Heat and Noxious Chemical Sensor, Chicken TRPA1, as a Target of Bird Repellents and Identification of Its Structural Determinants by Multispecies Functional Comparison｣
Molecular Biology and Evolution 31:708-722 (2014)
20. Kazumasa Nakatsuka, Rupali Gupta, Shigeru Saito, Nagako Banzawa, Kenji Takahashi, Makoto Tominaga, and Toshio Ohta
｢Identification of Molecular Determinants for a Potent Mammalian TRPA1 Antagonist by Utilizing Species Differences｣
Journal of Molecular Neuroscience 51:754-762 (2013)
21. Saeko Miura, Kenji Takahashi, Toshiaki Imagawa, Kunitoshi Uchida, Shigeru Saito, Makoto Tominaga, and Toshio Ohta
｢Involvement of TRPA1 Activation in Acute Pain induced by Cadmium in Mice.｣
Molecular Pain 9:7 (2013)
22. Shigeru Saito*, Kazumasa Nakatsuka, Kenji Takahashi, Naomi Fukuta, Toshiaki Imagawa, Toshio Ohta, and Makoto Tominaga
｢Analysis of Transient Receptor Potential Ankyrin 1 (TRPA1) in Frogs and Lizards Illuminates Both Nociceptive Heat and Chemical Sensitivities and Coexpression with TRP Vanilloid 1 (TRPV1) in Ancestral Vertebrates.｣
The Journal of Biological Chemistry 287: 30743-30754 (2012)
23. Hitomi Ogawa, Kenji Takahashi, Saeko Miura, Toshiaki Imagawa, Shigeru Saito, Makoto Tominaga, and Toshio Ohta
｢H2S Functions as a Nociceptive Messenger Through Transient Receptor Potential Ankyrin 1 (Trpa1) Activation.」
Neuroscience 218: 335–343 (2012)
24. Masashi Ohkita, Shigeru Saito, Toshiaki Imagawa, Kenji Takahashi, Makoto Tominaga, and Toshio Ohta
｢Molecular Cloning and Functional Characterization of Xenopus tropicalis Frog Transient Receptor Potential Vanilloid 1 Reveal Its Functional Evolution for Heat, Acid, and Capsaicin Sensitivities in Terrestrial Vertebrates.｣
The Journal of Biological Chemistry 287: 2388–2397 (2012)
25. Kazuya Nagai, Yasushi Saitoh, Shigeru Saito, and Ken-ichi Tsutsumi
｢Structure and Hibernation-associated Expression of the Transient Receptor Potential Vanilloid 4 Channel (TRPV4) mRNA in the Japanese Grass Lizard (Takydromus tachydromoides).｣
Zoological Science 29:185-190 (2012)
26. Shigeru Saito*, Naomi Fukuta, Ryuzo Shingai, and Makoto Tominaga
｢Evolution of Vertebrate Transient Receptor Potential Vanilloid 3 Channels: Opposite Temperature Sensitivity between Mammals and Western Clawed Frog.｣
PLoS Genetics 7: e1002041 (2011)
27. Naoki Takata, Shigeru Saito, Claire T. Saito, and Matsuo Uemura
｢Phylogenetic Footprint of the Plant Clock System in Angiosperms: Evolutionary Processes of Pseudo-Response Regulators.｣
BMC Evolutionary Biology 10: 126 (2010)
28. Masaki Kuro-o, Hiromichi Yonekawa, Shigeru Saito, Masaki Eda, Hiroyoshi Higuchi, Hiroko Koike, and Hiroshi Hasegawa
｢Unexpectedly High Genetic Diversity of mtDNA Control Region through Severe Bottleneck in Vulnerable Albatross Phoebastria albatrus.｣
Conservation Genetics 11:127-137 (2010)
29. Naoki Takata, Shigeru Saito, Claire T. Saito, Tokihiko Nanjo, Kenji Shinohara, and Matsuo Uemura
｢Molecular Phylogeny and Expression of Poplar Circadian Clock Genes, LHY1 and LHY2.｣
New Phytologist 181: 808-819 (2009)
30. Shigeru Saito*, Claire T. Saito, and Ryuzo Shingai
｢Adaptive Evolution of the Uncoupling Protein 1 Gene Contributed to the Acquisition of Novel Nonshivering Thermogenesis in Ancestral Eutherian Mammals｣
Gene 408:37-44 (2008)
31. Shigeru Saito* and Ryuzo Shingai
｢Evolution of ThermoTRP Ion Channel Homologs in Vertebrates｣
Physiological Genomics 27:219-230 (2006)
32. Shigeru Saito*, Koichiro Tamura, and Tadashi Aotsuka
｢Replication Origin of Mitochondrial DNA in Insects｣
Genetics 171:1695-1705 (2005)
総説
1. 齋藤 茂*
｢脊椎動物の温度感受性TRPチャネルの進化的な変化と環境適応｣
医学の歩み 270(10): 869-874 (2019) 査読無し
2. 齋藤 茂*、富永真琴
｢温度センサーTRPチャネルの生息環境に応じた機能進化とその構造基盤｣
生物物理 59(1):5-8 (2019) 査読有り
3. Shigeru Saito* and Makoto Tominaga.
Evolutionary tuning of TRPA1 and TRPV1 thermal and chemical sensitivity in vertebrates
Temperature 4:141-152 (2017) 査読有り
4. Shigeru Saito* and Makoto Tominaga.
｢Functional diversity and evolutionary dynamics of thermoTRP channels｣
Cell Calcium 57: 214-221 (2015) 査読有り
5. 齋藤 茂*
｢脊椎動物の温度感受性transient receptor potential (TRP) チャネルの多様性と機能進化｣
比較生理生化学 28: 259-266 (2011) 査読有り
6. 稲葉(伊東)靖子、齋藤 茂*
｢熱産生における脱共役タンパク質の役割と適応進化｣(解説).
化学と生物 (日本農芸化学会 会誌) 46(12): 841-849 (2008) 査読無し
著書
1. 齋藤 茂 ヒトゲノム辞典 第18.6章 「温覚に関わる遺伝子」、第18.7章「痛覚にかかわる遺伝子」p267-270. 一色出版 (2021)
2. 齋藤 茂 動物学の百科事典 ｢動物の温度調節｣ (1項目, 2ページ分) 丸善出版 (2018)
3. 齋藤 茂、新貝鉚蔵 温度と生命システムの相関学、第4章 ｢動物における温度センサーの進化｣ p72-87. 東海大出版会 (2009)