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Short Biography
Short Biography
Ana Maria Silva completed her LSc degree in Biochemistry in 1999, at the Faculty of Sciences and Technology, University of Coimbra (FCTUC). In 2009 she was conferred a MSc degree in Molecular and Cell Biology under the supervision of Prof. Rui de Carvalho and Prof. John Jones, at FCTUC. Ana Silva is finishing her PhD in Biosciences, specialization in Toxicology, in University of Coimbra, under the supervision of Prof. Vilma Sardão and co-supervision of Prof. Rui de Carvalho and Prof. Paulo Oliveira, which project is concerned about osteocyte metabolism and bone homeostasis in a postmenopausal condition, developed in the Center for Neuroscience and Cell Biology, Coimbra. Along her scientific activity linked to several projects, Ana Silva served as teacher of Physics-Chemistry in basic/secondary schools.
Currently, Ana Silva is working under the supervision of Prof. Pedro Fontes Oliveira (Sertoli Cell Biology Group) at Instituto de Ciências Biomédicas Abel Salazar, University of Porto, in the search for the level of commitment and physiology of aquoporins in male infertility, centering on the physiology of Sertoli cells. Her scientific interests include the transduction of extra-intracellular signals, cell metabolism in general and mitochondrial in particular, in varied cellular systems, as well as hormonal control and mechanisms of aging.
Funded projects
Funded projects
PTDC/BBB-BQB/1368/2014: "Aquaporins as molecular partners of CFTR in the Blood-Testis Barrier: a crossroad between human male infertility and cystic fibrosis?" - PI: Prof. Pedro Fontes Oliveira.
Ended funded projects
Ended funded projects
PTDC/AGR-ALI/108326/2008 (FCT): “Can Phytoestrogens be Safe and Effective Food Additives for Women During Menopause? - An In Vitro and In Vivo Approach to the problem.” - PI: Prof. Maria Sancha de Jesus Vieira dos Santos and Co-PI: Prof. Vilma Marisa Arrojado Soares Sardão Oliveira.
POCI/SAU-OBS/55802/2004 (FCT): “Influence of Transplant Preservation Solutions in Cardiac Metabolic and Immunological Profiles.” - PI: Prof. Rui de Albuquerque Carvalho.
POCTI/NSE/42123/2001 (FCT): “K-ATP channel-dependent and -independent pathways in pancreatic beta- cells from normal and non-obese type 2 diabetic rodents.” - PI: Prof. Luís Manuel de Oliveira Martinho do Rosário.
PRAXIS/P/SAU/13184/98 (JNICT): “Study of the cellular mechanisms associated to pulsatile of insulin secretion and etiology of Type II Diabetes – electrophysiological analysis.” - PI: Prof. Rosa Maria Moreira Alves dos Santos.
Fellowships and Prizes
Fellowships and Prizes
2017 – 8-months research fellowship for a master technician from the project PTDC/BBB-BQB/1368/2014 (FCT).
2015 - “ECTS-IBMS New Investigator Award for an Outstanding Work”, supported by Elsevier in the 4th Joint Meeting of ECTS (European Calcified Tissue Society) and IBMS (International Bone and Mineral Society), April 25-28th, Rotterdam, The Netherlands.
2013 - “Outstanding Poster Communication award” in the 47th Annual Meeting of the European Society of Clinical Investigation, April 17th-20th, Albufeira, Portugal.
2012 – 4-year PhD fellowship from the Portuguese Foundation for Science and Technology (FCT)
2010 – 2-year research fellowship for a master technician from the project PTDC/AGR-ALI/108326/2008 (FCT).
2007 – 1-year research fellowship for a licensed technician from the project POCI/SAU-OBS/55802/2004 (FCT).
2000 – 2-year research fellowship for a licensed technician from the project POCTI/NSE/42123/2001 (FCT).
1996 – Gulbenkian Foundation grant to attend the “Thirty Eighth London International Youth Science Forum, July 24th-August 7th, London, UK.
Book chapters
Book chapters
2. Videira, RA, Silva, AM, Sardão, VA, Oliveira, MM, Peixoto, FP & Jurado, AS (2013). Chapter 4. Insecticide interactions with biological membranes: From membrane partition to biophysical effects. A Toxicological/Pharmacological Approach to Chemico-Biological Interactions at a Membrane Level, 71-92 ISBN: 978-81- 308-0494- 1.
1. Silva, AM & Oliveira, PJ (2012). Evaluation of respiration with Clark-type electrode in isolated mitochondria and permeabilized animal cells. Methods in Molecular Biology, Mitochondrial Bioenergetics: Methods and Protocols. Methods Mol Biol; 810:7-24, doi: 10.1007/978-1- 61779-382-0_2. PubMed PMID: 22057558.
Publications
Publications
*authors contributed equally
10. Moreira, AC, Silva, AM, Santos, MS, Branco, AF, Baldeiras, I, Pereira, GC, Seiça, R, Santos, MS & Sardão, VA. Phytoestrogen coumestrol improves mitochondrial activity and decreases oxidative stress in the brain of ovariectomized Wistar-Han rats. Journal of Functional Foods 34, July (2017) |doi.org/10.1016/j.jff.2017.05.002.
9. Silva, AM, Moreira, AC, Santos, MS, Dias, JR, Alves, N, Videira, RA, Carvalho, RA & Sardão, VA (2015). Estradiol modulates and recovers osteocyte metabolic/lipid profiles after ovariectomy in acute and long-term in vivo hormone replacement therapeutics. IBMS BoneKEy 13, Article number: 675 |doi:10.1038/bonekey.2015.42.
8. Moreira, AC, Silva, AM, Santos, MS & Sardão, VA (2014). Phytoestrogens as alternative hormone replacement therapy in menopause: What is real, what is unknown. J Steroid Biochem Mol Biol. 2014 Sep;143:61-71. doi: 10.1016/j.jsbmb.2014.01.016. Epub 2014 Feb, PubMed PMID:24583026.
7. Monteiro, JP, Silva, AM, Jurado, AS & Oliveira, PJ (2013). Rapeseed oil-rich diet alters in vitro menadione and nimesulide hepatic mitochondrial toxicity. Food Chem Toxicol.,Oct;60:479-87. doi: 10.1016/j.fct.2013.07.073. Epub 2013 Aug 6, PubMed PMID: 23933359.
6. Cunha-Oliveira, T, Silva, L, Silva, AM, Moreno, AJ, Oliveira, CR & Santos, MS (2013). Acute effects of cocaine, morphine and their combination on bioenergetic function and susceptibility to oxidative stress of rat liver mitochondria. Life Sci. 2013 Jul 10;92(24-26):1157- 64. doi:10.1016/j.lfs.2013.04.016. Epub 2013 May 13, PubMed PMID: 23680378.
5. Monteiro, JP, Pereira, CV, Silva, AM, Maciel, E, Baldeiras, I, Peixoto, F, Domingues, MR, Jurado, AS & Oliveira, PJ (2013). Rapeseed oil-rich diet alters hepatic mitochondrial membrane lipid composition and disrupts bioenergetics. Arch Toxicol.; May 1, PubMed PMID: 23636270.
4. Cunha-Oliveira,T, Silva, L, Silva, AM, Moreno, AJ, Oliveira, CR & Santos, MS (2013). Mitochondrial complex I dysfunction induced by cocaine and cocaine plus morphine in brain and liver mitochondria. Toxicol Lett. Jun 7;219(3):298-306. doi:10.1016/j.toxlet.2013.03.025. Epub 2013 Mar 29. PubMed PMID: 23542814.
3. Moreira, AC, Silva, AM, Santos, MS & Sardão, VA (2013). Resveratrol Affects Differently Rat Liver and Brain Mitochondrial Bioenergetics and Oxidative Stress in vitro: Investigation of the Role of Gender, Food and Chemical Toxicology 2013, 53, 18-26, doi: 10.1016/j.fct.2012.11.031. Epub 2012 Nov 29. PubMed PMID: 23200887.
2. Pereira, GC, Silva, AM, Diogo, CV, Carvalho, FS, Monteiro, P & Oliveira, PJ (2011). Drug-induced Cardiac Mitochondrial Toxicity and Protection: From Doxorubicin to Carvedilol. Curr Pharm Des.;17(20):2113-29. Review, PubMed PMID: 21718248.
1. Silva, AM, Martins, F, Jones, JG & Carvalho, RA (2011). 2H2O Incorporation Into Hepatic Acetyl-CoA and De novo Lipogenesis as Measured by Krebs Cycle-Mediated 2H-Enrichment of Glutamate and Glutamine. Magn Reson Med., May 23 doi: 10.1002/mrm.22955. Epub 2011 May 23. PubMed PMID: 21608032.
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