Monteiro JP

Short Biography:

João Pedro Monteiro completed his LSc degree in Biochemistry in 2002, at the University of Coimbra. In 2007, João finished a MSc in Cell Biology at the same institution.

In 2013, João completed his PhD in Biosciences (Toxicology Branch), which resulted from a collaboration between the Universities of Coimbra and Warwick (UK). The work aimed at studying the influence of diet in mitochondrial function and composition.

After finishing his PhD, João joined CICS (University of Beira Interior) and worked for a year in proteomics, and in the planning and development of a new mass spectrometry laboratory. In 2014, João moved to Porto and started working at CBQF (Catholic University of Portugal) where he was assigned more managerial duties.

Currently, João P. Monteiro is a Post-Doctoral fellow at the Institute of Biomedical Sciences Abel Salazar, University of Porto – ICBAS/UP under the scope of the FTC funded project "Aquaporins as molecular partners of CFTR in the Blood-Testis Barrier: a crossroad between human male infertility and cystic fibrosis?" (PTDC/BBB-BQB/1368/2014).

Fellowships and Prizes:

2016 - Post-Doc fellowship from Portuguese Foundation for Science and Technology under the scope of the project "Aquaporins as molecular partners of CFTR in the Blood-Testis Barrier: a crossroad between human male infertility and cystic fibrosis?"

2014 - Post-Doc fellowship INCENTIVO/EQB/LA0016/2014 BPD_2 funded by FCT/MEC through national funds (PIDDAC), at CBQF (Catholic University of Portugal).

2013 - Post-Doc fellowship HIB-3-001 within the project with reference CENTRO-07-ST24-FEDER-002015, titled “Hormonal and Inflammatory basis of age-related diseases”, funded by QREN (“Mais Centro” Program), at CICS (University of Beira Interior).

2007 - PhD FCT fellowship (SFRH/BD/37626/2007).

Proceedings in Peer-reviewed Journals:

2. Monteiro JP, Jesus TT, Crisóstomo L, Sousa M, Barros A, Oliveira PF, Alves MG (2017). mTOR coordinates the response to available energy substrates in human Sertoli cells: A defining point for male fertility? FEBS J. 284 (Suppl. 1): SpT.5.4-002. DOI: 10.1111/febs.14171

1. Monteiro JP, Silva AM, Jurado AS, Oliveira PJ (2013) Rapeseed oil-rich diet impacts hepatic mitochondrial physiology and in vitro menadione and nimesulide toxicity. Eur J Clin Invest 43(Suppl. 1):53.

Book chapters:

2. Monteiro JP, Jurado, AS (2014) Methoprene. In Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol 3. Elsevier Inc., Academic Press, 246–249

1. Monteiro JP, Burgeiro A, Oliveira PJ (2013) Mitochondrial Lipids In Cell Physiology and Toxicology. In A toxicological/pharmacological approach to chemico-biological interactions at a membrane level, Research Signpost, Transworld Research Networks.

Publications:

15. Monteiro JP, Alves MG, Oliveira PF, Silva BM (2016) Structure–bioactivity relationship of methylxanthines: Trying to make sense of all the promises and the drawbacks. Molecules. 21(8): 974. (DOI:10.3390/molecules21080974)

14. Monteiro JP, Santos FM, Rocha AS, Castro-de-Sousa JP, Queiroz JA, Tomaz CT, Passarinha LA (2015) Vitreous humor in the pathologic scope: Insights from proteomic approaches. Proteomics Clin Appl 9(1-2):187-202 (DOI: 10.1002/prca.201400133).

13. Monteiro JP., Morais CM, Oliveira PJ, Jurado AS (2014) Mitochondrial membrane lipids in life and death and their molecular modulation by diet: Tuning the furnace. Curr Drug Targets 15(8):797-810 (DOI: 10.2174/1389450115666140623115315).

12. Rocha AS, Santos FM, Monteiro JP, Castro-de-Sousa JP, Queiroz JA, Tomaz CT, Passarinha LA (2014) Trends in proteomic analysis of human vitreous humor samples. Electrophoresis 35(17):2495-2508 (DOI: 10.1002/elps.201400049).

11. Monteiro JP, Silva AM, Jurado AS, Oliveira PJ (2013) Rapeseed oil-rich diet alters in vitro menadione and nimesulide hepatic mitochondrial toxicity. Food Chem Toxicol 60:479-487 (DOI: 10.1016/j.fct.2013.07.073).

10. Monteiro JP, Oliveira PJ, Jurado AS (2013) Mitochondrial membrane lipid remodeling in pathophysiology: A new target for diet and therapeutic interventions. Prog Lipid Res 52:513–528 (DOI: 10.1016/j.plipres.2013.06.002).

09. Monteiro JP, Martins AF, Lúcio M, Reis S, Pinheiro TJ, Geraldes CF, Oliveira PJ, Jurado AS (2013) A biophysical approach to menadione membrane interactions: relevance for menadione-induced mitochondria dysfunction and related deleterious/therapeutic effects. BBA Biomembranes 1828:1899-1908 (DOI: 10.1016/j.bbamem.2013.04.006).

08. Monteiro JP, Pereira CV, Silva AM, Maciel E, Baldeiras I, Peixoto F, Domingues MR, Jurado AS, Oliveira PJ (2013) Rapeseed oil-rich diet alters hepatic mitochondrial membrane lipid composition and disrupts bioenergetics. Arch Toxicol 87(12):2151-2163 (DOI: 10.1007/s00204-013-1068-7).

07. Monteiro JP, Martins AF, Lúcio M, Reis S, Pinheiro TJ, Geraldes CF, Oliveira PJ, Jurado AS (2011) Nimesulide interaction with membrane model systems: Are membrane physical effects involved in nimesulide mitochondrial toxicity? Toxicol In Vitro 25(6):1215-1223 (DOI: 10.1016/j.tiv.2011.05.014).

06. Monteiro JP, Martins AF, Lúcio M, Reis S, Geraldes CF, Oliveira PJ, Jurado AS (2011) Interaction of carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) with lipid membrane systems: a biophysical approach with relevance to mitochondrial uncoupling. J Bioenerg Biomembr 43(3):287-298 (DOI: 10.1007/s10863-011-9359-2).

05. Monteiro JP, Videira RA, Matos MJ, Dinis AM, Jurado AS (2008) Non-selective toxicological effects of the insect juvenile hormone analogue methoprene. A membrane biophysical approach. Appl Biochem Biotechnol 150(3):243-257 (DOI: 10.1007/s12010-007-8127-6).

04. Monteiro JP, Oliveira PJ, Moreno AJ, Jurado AS (2008) Disruption of hepatic mitochondrial bioenergetics is not a primary mechanism for the toxicity of methoprene - relevance for toxicological assessment. Chemosphere 72(9):1347-1354 (DOI: 10.1016/j.chemosphere.2008.04.024).

03. Monteiro JP, Jurado AS, Moreno AJM, Madeira VMC (2005) Toxicity of methoprene as assessed by the use of a model microorganism. Toxicology in Vitro 19:951-956 (DOI: 10.1016/j.tiv.2005.06.020).

02. Monteiro JP, Martins JD, Luxo PC, Jurado AS, Madeira VMC (2003) Molecular mechanisms of the metabolite 4-hydroxytamoxifen of the anticancer drug tamoxifen: use of a model microorganism. Toxicol In Vitro 17:629-634 (DOI: 10.1016/S0887-2333(03)00111-5).

01. Martins JD, Monteiro JP, Antunes-Madeira MC, Jurado AS, Madeira VMC (2003) Use of the microorganism Bacillus stearothermophilus as a model to evaluate toxicity of the lipophilic environmental pollutant endosulfan. Toxicol In Vitro 17:595-601 (DOI: 10.1016/S0887-2333(03)00090-0).

Peer-reviewer in international scientific journals

Current Medicinal Chemistry (ISSN: 0929-8673)