Dias TR

Short Biography:

In 2010, Tânia Dias completed her LSc degree in Biomedical Sciences, at the University of Beira Interior, Covilhã, Portugal. In 2012, she was conferred a MSc degree in Biomedical Sciences, also at the University of Beira Interior, Covilhã, Portugal. She is presently a PhD student in Biomedicine, at Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal. However, part of her PhD project is being developed at the Unit for Multidisciplinary research in Biomedicine (UMIB), at the Institute of Biomedical Sciences Abel Salazar, Porto, Portugal. Her PhD project is under the supervision of Professor Pedro F. Oliveira (UMIB-ICBAS; i3S) and co-supervision of Professor Branca M. Silva (CICS-UBI), and Professor Susana Casal (LAQV/REQUIMTE-UP). Her research interests are focused on male reproductive biology, more specifically the study of diabetes, antioxidants, cell metabolism regulation and their implications on male fertility.

Ended funded Projects:

2012-2015: PTDC/QUI-BIQ/121446/2010: “Can Hormonal (De)regulation of Ion Transporters in Human Sertoli Cells be Responsible for Infertility?”, P.I.: Pedro Fontes Oliveira.

Fellowships and Prizes:

2018: Fulbright Enrichment Seminar scholarship, "Global Health Innovations Seminar”, Atlanta, Georgia, USA (28 Feb-4 March, 2018).

2017: MiPschool 2017 MITOEAGLE and MITOEAGLE workshop extended scholarship, for presenting her work at the 10th MiPschool and attend the MITOEAGLE workshop, Obergurgl, Austria, 23-30 July 2017.

2017: Fulbright research scholarship with the support from the Portuguese Foundation for Science and Technology (FCT) for the academic year 2017/2018.

2015: 4-year PhD fellowship (SFRH/BD/109284/2015) from the Portuguese “Fundação para a Ciência e a Tecnologia: FCT” in the area of medicinal chemistry.

2013 - 2015: CENTRO-07-ST24-FEDER-002015 entitled “Hormonal and Inflammatory basis of age-related diseases” funded by Programa Operacional Regional do Centro 2007-2013 QREN (Programa “Mais Centro”), Health Sciences Research Centre, Faculty of Health Sciences, Covilhã, Portugal.

Proceedings in Peer-reviewed Journals:

11. Meneses MJ, Dias TR, Martins FO, Borges DO, Oliveira PF, Macedo MP, Alves MG (2016) “O Knock-out do gene que codifica a insulisina diminui a qualidade espermática de ratinhos” 7th Workshop in Clinical Biochemistry in Acta Farmacêutica Portuguesa 5(2): pp. 115-120

10. Dias TR, Alves MG, Silva J, Barros A, Sousa M, Casal S, Silva BM, Oliveira PF (2016) "Effect of epigallocatechin gallate in human Sertoli cells metabolism and mitochondrial function: implications for spermatogenesis". 50th Annual Scientific Meeting of the European Society for Clinical Investigation in European Journal of Clinical Investigation. 46(S1):122-3. ISSN: 1365-2362 (DOI: 10.1111/eci.12603)

9. Dias TR, Alves MG, Almeida SP, Silva J, Barros A, Sousa M, Silva BM, Silvestre SM, Oliveira PF (2016) "Modulation of human Sertoli cells metabolism by precursors of androgen synthesis: new insights on the role of dehydroepiandrosterone and 7-oxo-dehydroepiandrosterone". 50th Annual Scientific Meeting of the European Society for Clinical Investigation in European Journal of Clinical Investigation. 46(S1):121. ISSN: 1365-2362 (DOI: 10.1111/eci.12603)

8. Dias TR, Alves MG, Almeida SP, Silva J, Barros A, Sousa M, Silva BM, Silvestre SM, Oliveira PF (2016) "New insights into the regulation of human Sertoli cells metabolism: differential effects of dehydroepiandrosterone and 7-oxo-dehydroepiandrosterone". UMIB Summit 2015 in Medicine. 95(10): e02371 (DOI:10.1097/MD.0000000000002371)

7. Nunes AR, Alves MG, Dias TR, Cristóvão AC, Moreira PI, Oliveira PF, Silva BM (2016) "White tea consumption improves the glycolytic and oxidative profiles of cerebral cortex of prediabetic Wistar rats: a possible role for neuroprotection?" UMIB Summit 2015 in Medicine. 95(10): e02371 (DOI:10.1097/MD.0000000000002371)

6. Silva BM, Tomás GD, Dias TR, Martins AD, Rato L, Alves MG, Oliveira PF (2016) "Sperm quality of pre-diabetic Wistar rats is restored after a diet with white tea". UMIB Summit 2015 in Medicine. 95(10): e02371 (DOI:10.1097/MD.0000000000002371)

5. Rato L, Alves MG, Dias TR, Cavaco JE, Oliveira PF (2016) "Testicular metabolic reprogramming in neonatal streptozotocin-induced type 2 diabetic rats impairs glucose metabolism and promotes glycogen accumulation". UMIB Summit 2015 in Medicine. 95(10): e02371 (DOI:10.1097/MD.0000000000002371)

4. Dias TR, Alves MG, Bernardino RL, Martins AD, Moreira AC, Silva J, Sousa M, Silva BM, Oliveira PF (2016) "Cafeína e fertilidade masculina: efeitos metabólicos e perfil oxidativo em células de Sertoli humanas". IV Encontro Nacional de Pós-Graduação em Ciências Biológicas in CAPTAR 6(1): 28-29. ISSN: 1647-323X

3. Silva BM, Alves MG, Nunes AR, Dias TR, Moreira PI, Oliveira PF (2015) "White tea consumption improves heart and brain glycolytic and oxidative profiles in prediabetic rats". 63rd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research in Planta Medica 81(16):PW_83 (DOI: 10.1055/s-0035-1565707)

2. Dias TR, Alves MG, Silva J, Barros A, Sousa M, Casal S, Silva BM, Oliveira PF (2015) "Epigallocatechin-3-gallate alters the metabolic phenotype of human Sertoli cells but protects from oxidative damage: a possible role for male fertility?" 63rd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research in Planta Medica 81(16):PW_59 (DOI: 10.1055/s-0035-1565683)

1. Dias TR, Alves MG, Bernardino RL, Martins AD, Moreira AC, Silva J, Barros A, M. Sousa, Silva BM, Oliveira PF (2015). Caffeine-induced alterations in human Sertoli cells metabolism and oxidative profile. 40th FEBS Congress, The Biochemical Basis of Life in FEBS J. 282(Suppl. 1):386. (DOI: 10.1111/febs.13339)

Book Chapters:

5. Dias TR, Carrageta DF, Alves MG, Oliveira PF, Silva BM. (2017) White tea extract. In Nonvitamin and Nonmineral Nutritional Supplements. Editors: S.N. Nabavi & A.S. Silva - Elsevier: Amsterdam, Holland (in press).

4. Dias TR, Alves MG, Silva BM, Oliveira PF (2018) “Nutritional factors and male reproduction” In “Reference Module in Biomedical Sciences", Elsevier (DOI:10.1016/B978-0-12-801238-3.64616-0).

3. Dias TR (2017) Functional and Biochemical Aspects of Spermatozoa. In: Alves MG, Oliveira PF (eds) Biochemistry of Andrology, vol 1. Andrology: Current and Future Developments. Bentham Science Publishers, Sharjah, UAE, pp 230-256. ISBN: 978-1-68108-501-2

2. Dias TR, Bernardino RL (2017) Biochemical Events Occurring in the Epididymis. In: Alves MG, Oliveira PF (eds) Biochemistry of Andrology, vol 1. Andrology: Current and Future Developments. Bentham Science Publishers, Sharjah, UAE, pp 178-206. ISBN: 978-1-68108-501-2

1. Dias TR, Alves MG, Neuhaus-Oliveira A, Socorro S, Silva BM, Oliveira PF (2013) Implications of Diabetes on sperm glucose uptake and metabolism. In Glucose Uptake: Regulation, Signaling Pathways and Health Implications, Nova Science Publishers, Inc, New York, USA. ISBN: 978-1-62618-671-2.

Publications:

23. Carrageta DF, Dias TR, Jarak I, Alves MG, Oliveira PF, Van der Walt MM, Terre’Blanche G, Monteiro MP, Silva BM (2018) 8-(3-phenylpropyl)-1,3,7-triethylxanthine is a synthetic caffeine substitute with stronger metabolic modulator activity. Toxicology in Vitro. 53:114-120 3.1 3.2 - Toxicology (Q2). (DOI:10.1016/j.tiv.2018.08.002)

22. Carrageta DF, Dias TR, Alves MG, Oliveira PF, Monteiro MP, Silva BM (2018) Anti-obesity potential of natural methylxanthines. Journal of Functional Foods. 43:84-94. (DOI: https://doi.org/10.1016/j.jff.2018.02.001)

21. Dias TR, Alves MG, Silva J, Barros A, Sousa M, Casal S, Silva BM, Oliveira PF (2017) Implications of epigallocatechin-3-gallate in cultured human Sertoli cells glycolytic and oxidative profile. Toxicology In Vitro. 41:214-222 (DOI:10.1016/j.tiv.2017.03.006).

20. Silva BM, Oliveira PF, Alves MG, Dias TR (2017) Editorial: Bioactive Substances from Medicinal Plants for Metabolic Disorders. Curr Med Chem. 24(4):332-333.(DOI:10.2174/092986732404170302223350)

19. Dias TR, Alves MG, Casal S, Silva BM, Oliveira PF (2016) Promising potential of dietary (poly)phenolic compounds in the prevention and treatment of diabetes mellitus. Current Medicinal Chemistry. 24(4):334-354 (DOI:10.2174/0929867323666160905150419).

18. Dias TR, Alves MG, Rato L, Casal S, Silva BM, Oliveira PF (2016) White tea intake prevents prediabetes-induced metabolic dysfunctions in testis and epididymis preserving sperm quality. J Nutr Biochem. 37:83-93 (DOI: 10.1016/j.jnutbio.2016.07.018)

17. Dias TR, Bernardino RL, Meneses MJ, Sousa M, Sá R, Alves MG, Silva BM, Oliveira PF (2016) Emerging potential of natural products as an alternative strategy to pharmacological agents used against metabolic disorders” Curr Drug Metab. 17(6): 582-597. (DOI: 10.2174/1389200217666160229113629)

16. Dias TR, Alves MG, Casal S, Silva BM, Oliveira PF (2016) Single and synergistic effect of major tea components caffeine, epigallocatechin-3-gallate and L-theanine in rat sperm viability. Food Funct. 7(3):1301-5 (DOI: 10.1039/C5FO01611H)

15. Oliveira PF*, Tomás GD*, Dias TR, Martins AD, Rato L, Alves MG, Silva BM (2015) White tea consumption restores sperm quality in prediabetic rats preventing testicular oxidative damage. Reprod Biomed Online. 31(4): 544-556 (DOI: 10.1016/j.rbmo.2015.06.021)

14. Dias TR, Alves MG, Almeida SP, Silva J, Barros A, Sousa M, Silva BM, Silvestre SM, Oliveira PF (2015) Dehydroepiandrosterone and 7-oxo- dehydroepiandrosterone in male reproductive health: implications of differential regulation of human Sertoli cells metabolic profile. J. Steroid. Biochem. Mol. Biol. 154:1-11 (DOI: 10.1016/j.jsbmb.2015.06.004).

13. Rato L, Alves MG, Dias TR, Cavaco JE, Oliveira PF (2015) Testicular Metabolic Reprogramming in Neonatal Streptozotocin-Induced Type 2 Diabetic Rats Impairs Glycolytic Flux and Promotes Glycogen Synthesis. Journal of Diabetes Research. (DOI: 10.1155/2015/973142)

12. Dias TR, Alves MG, Bernardino RL, Martins AD, Moreira AC, Silva J, Barros A, Sousa M, Silva BM, Oliveira PF (2015) Dose-dependent effects of caffeine in human Sertoli cells metabolism and oxidative profile. Toxicology. 328:12-20 (DOI:10.1016/j.tox.2014.12.003)

11. Dias TR, Alves MG, Oliveira PF, Silva BM (2015) Natural products as modulators of spermatogenesis: the search for a male contraceptive. Curr. Mol. Pharmacol. 7(2): 154-166 (DOI:10.2174/1874467208666150126155912)

10. Alves MG, Dias TR, Silva BM, Oliveira PF (2015) Metabolic cooperation in testis as a pharmacological target: from disease to contraception. Curr. Mol. Pharmacol. 7(2): 83-95 (DOI: 10.2174/1874467208666150126153830)

9. Dias TR, Alves MG, Silva BM, Oliveira PF (2014) Sperm glucose transport and metabolism in diabetic individuals. Mol. Cell. Endocrinol. 396(1-2): 37-45 (DOI: 10.1016/j.mce.2014.08.005).

8. Dias TR, Alves MG, Tomás GD, Socorro S, Silva BM, Oliveira PF (2014) White tea as a promising antioxidant media additive for sperm storage at room temperature: a comparative study with green tea. J. Agric. Food Chem. 62 (3): 608–617 (DOI:10.1021/jf4049462)

7. Martins AD, Alves MG, Bernardino RL, Dias TR, Silva BM, Oliveira PF. (2014) Effect of white tea (Camellia sinensis (L.)) extract in the glycolytic profile of Sertoli cell. Eur. J. Nut. (DOI: 10.1007/s00394-013-0640-5).

6. Dias TR, Martins AD, Reis VP, Socorro S, Silva BM, Alves MG, Oliveira PF (2013) Glucose transport and metabolism in Sertoli cell: relevance for male fertility. Cur. Chem. Biol. 7(3):282-93. (DOI: 10.2174/2212796807999131128125510)

5. Dias TR, Rato L, Martins AD, Simões AD, Jesus TT, Alves MG, Oliveira PF (2013) Insulin deprivation decreases caspase-dependent apoptotic signaling in cultured rat Sertoli cells. ISRN Urology ID:970370. (DOI:10.1155/2013/970370)

4. Martins AD*, Alves MG*, Simões VL, Dias TD, Rato L, Moreira PI, Socorro S, Cavaco JE, Oliveira PF (2013) Control of Sertoli cell metabolism by sex steroid hormones is mediated through modulation in glycolysis-related transporters and enzymes. Cell Tissue Res. 354(3):861-8. (DOI:10.1007/s00441-013-1722-7)

3. Dias TR, Tomás G, Teixeira NF, Alves MG, Oliveira PF, Silva BM (2013) White Tea (Camellia Sinensis (L.)): Antioxidant Properties and Beneficial Health Effects. Int. J.Food Sci. Nut. Diet. 2(2): 1-15.

2. Rato L, Alves MG, Dias TR, Lopes G, Cavaco JE, Socorro S, Oliveira PF (2013) High-energy diets may induce a pre-diabetic state altering testicular glycolytic metabolic profile and male reproductive parameters. Andrology 1(3): 495–504. (DOI: 10.1111/j.2047-2927.2013.00071.x)

1. Simões VL, Alves MG, Martins AD, Dias TD, Rato L, Socorro S, Oliveira PF (2013) Regulation of Apoptotic Signalling Pathways by 5α-dihydrotestosterone and 17β-estradiol in Immature Rat Sertoli Cells. J. Steroid Biochem. Mol. Biol. 135(1): 15-23. (DOI:10.1016/j.jsbmb.2012.11.019)

Peer-reviewer in international scientific journals:

Journal of Physiology and Pharmacology (ISSN: 0867-5910)

Journal of Chemistry (ISSN: 2090-9063)

Current Pharmaceutical Design (ISSN: 1381-6128)

Therapeutic Advances in Endocrinology and Metabolism (ISSN: 20420188)

Theriogenology (ISSN: 0093-691X)