Bárbara G. Carvalho, B.Sc.

Bárbara Guerra-Carvalho, B.Sc.

Ph.D. Student

Supervision: Prof. Rui A. Carvalho (FCV-UC)
Co-supervision: Prof. Marco G. Alves, Prof. Pedro F. Oliveira (QOPNA/LAQV-UA)

barbaraggcarvalho@gmail.com
ORCID: 0000-0003-3276-5094

Short Biography

Bárbara Carvalho completed her LSc degree in Biochemistry in 2018, at the University of Coimbra, Coimbra, Portugal. Currently she is a PhD student in Biosciences with specialization in Biochemistry, at the University of Coimbra. Her scientific interests include cell metabolism and metabolomics, particularly in spermatozoa.

Fellowships and Prizes

2022 - ESCI Travel Grant to attend the 56th Annual Scientific Meeting of ESCI, 8-10th June 2022, Bari, Italy. 

2022 Basic Science Travel Grant from the European Society of Endocrinology to attend the European Congress of Endocrinology, 21th-24th May 2022, Milan, Italy. 

2020 – Flash and short talks award, “Activation of mTOR pathway during short-term preservation increases spermatozoa glycolytic activity”, at the ESCI Virtual Meeting 2020 - COVID 19 Edition.

2019 - ESCI Travel Grant to participate in the 53rd Annual Scientific Meeting of ESCI in Coimbra, Portugal.

2019 - 3% Best Students Award, by the University of Coimbra, Coimbra, Portugal. 

Publications

13. Gomes-Andrade D, Guerra-Carvalho B, Carrageta DF, Bernardino RL, Braga PC, Oliveira PF, Pereira ML, Alves MG. Exposure to toxicologically relevant atrazine concentrations impair the glycolytic function of mouse Sertoli cells through the downregulation of lactate dehydrogenase, Toxicology and Applied Pharmacology, Volume 486, 2024. https://doi.org/10.1016/j.taap.2024.116929

12. Guerra-Carvalho B, Jarak I, Carvalho RA, Pinto S, Correia SC, Barros A, Alves MG, Oliveira PF. Metabolomics of Human Seminal Fluid Reveals Aging-Related Increase in the Amino Acid Content. Journal of Biological Regulators and Homeostatic Agents. 2024, 38(4): 2945-2958 https://doi.org/10.23812/j.biol.regul.homeost.agents.20243804.230

11. Pinto S, Guerra-Carvalho B, Crisóstomo L, Rocha A, Barros A, Alves MG, Oliveira PF. Metabolomics Integration in Assisted Reproductive Technologies for Enhanced Embryo Selection beyond Morphokinetic Analysis. International Journal of Molecular Sciences. 2024; 25(1):491. https://doi.org/10.3390/ijms25010491

10. Madama, D.; Carrageta, D.F.; Guerra-Carvalho, B.; Botelho, M.F.; Oliveira, P.F.; Cordeiro, C.R.; Alves, M.G.; Abrantes, A.M. Impact of Different Treatment Regimens and Timeframes in the Plasmatic Metabolic Profiling of Patients with Lung Adenocarcinoma. Metabolites 2023, 13, 1180. https://doi.org/10.3390/metabo13121180

9. Carrageta DF, Freire-Brito L, Guerra-Carvalho B, Bernardino RL, Monteiro BS, Barros A., Oliveira PF, Monteiro MP, Alves MG. (2023). Mitochondrial uncoupling proteins regulate the metabolic function of human Sertoli cells. Reproduction (published online ahead of print 2023), REP-23-0229. Retrieved Dec 11, 2023, from https://doi.org/10.1530/REP-23-0229

8. Luís C; Guerra-Carvalho B; Braga PC; Guedes C; Patrício E; Alves MG; Fernandes R; Soares R. The Influence of Adipocyte Secretome on Selected Metabolic Fingerprints of Breast Cancer Cell Lines Representing the Four Major Breast Cancer Subtypes. Cells 12,17. DOI: 10.3390/cells12172123

7. Braga PC, Bernardino RL, Guerra-Carvalho B, Carrageta DF, Oliveira PF, Rodrigues AS, Alves MG. The progression from mild to severe hyperglycemia coupled with insulin resistance causes mitochondrial dysfunction and alters the metabolic secretome of epithelial kidney cells. Experimental Cell Research. 2023. 113744. https://doi.org/10.1016/j.yexcr.2023.113744

6. Carrageta DF, Freire-Brito L, Guerra-Carvalho B, Ribeiro JC, Monteiro BS, Barros A, Oliveira PF, Monteiro MP, Alves MG. Inhibition of Mitochondrial Uncoupling Proteins Arrests Human Spermatozoa Motility without Compromising Viability. Antioxidants. 2023; 12(2):409. https://doi.org/10.3390/antiox12020409

5. Guerra-Carvalho B, Alves MG, Oliveira PF (2022) Obesity and Male Infertility: An Overview. Int J Diabetol Vasc Dis Res. 2022;8(1e):1-3. DOI: 10.19070/2328-353X

4. Carrageta DF*, Guerra-Carvalho B*, Spadella MA, Yeste M, Oliveira PF, Alves MG (2022) Animal models of male reproductive ageing to study testosterone production and spermatogenesis. Rev Endocr Metab Disord 2022. DOI: 10.1007/s11154-022-09726-9

3. Moreira MV, Pereira SC, Guerra-Carvalho B, Carrageta DF, Pinto S, Barros A, Silva BM, Oliveira PF, Alves MG (2022) Hyperoside Supplementation in Preservation Media Surpasses Vitamin C Protection Against Oxidative Stress-induced Damages in Human Spermatozoa. Cell Physiol Biochem 2022;56(S1):1-23. DOI: 10.33594/000000487

2. Guerra-Carvalho B*, Carrageta DF*, Crisóstomo L*, Carvalho RA, Alves MG, Oliveira PF (2021). Molecular mechanisms regulating spermatogenesis in vertebrates: Environmental, metabolic, and epigenetic factor effects. Animal reproduction science, 106896. doi:10.1016/j.anireprosci.2021.106896 

1. Carrageta DF*, Guerra-Carvalho B*, Sousa M, Barros A, Oliveira PF, Monteiro MP, Alves MG (2020) Mitochondrial Activation and Reactive Oxygen-Species Overproduction during Sperm Capacitation are Independent of Glucose Stimuli. Antioxidants, 9(8), 750. doi: 10.3390/antiox9080750

*both authors contributed equally