David F. Carrageta, M.Sc.

2023 – R&D@USA grant from FLAD "Fundação Luso-Americana para o Desenvolvimento"

2022 – ESE Basic Science Meeting Grant. European Congress of Endocrinology 2021, 22-26th May (online meeting).

2022 – ESCI Travel Grant to attend the 56th Annual Scientific Meeting of ESCI, 8-10th June 2022, Bari, Italy.  

2022 – Basic Science Travel Grant from the European Society of Endocrinology to attend the European Congress of Endocrinology, 21th-24th May 2022, Milan, Italy. 

2021 – Best Selected Talk Award – WebRePRO - I Reproductive Sciences & Fertility Virtual Summit, 26th-27th July (Online). 

2021 – FEBS Bursary. 45th FEBS Congress 2021, 3-8th July (online meeting).

2021 – Best Poster Award – Basic Science at the European Congress of Endocrinology (ECE 2021)

2021 – ESE Basic Science Meeting Grant. European Congress of Endocrinology 2021, 22-26th May (online meeting).

2020 – ECO/ICO 2020 travel grant to attend the European Congress of Obesity 2020, 17th-20th May 2020, Dublin, Ireland.

2018 – COST action (CA15203) grant as a meeting participant in the MiP2018/MitoEAGLE 18th-21th September, Jurmala, Latvia.

2018 – 4-year PhD fellowship (SFRH/BD/2018) from the Portuguese Foundation for Science and Technology (FCT) in the area of Clinical Medicine and Health Sciences.

2017 – CoCoTea 2017 scholarship, for attendance at the 4th International Congress on Cocoa, Coffee and Tea, Turin, Italy, 25-28 July 2017.

3. Carrageta D.F., Oliveira P.F., Monteiro M.P., Alves M.G. (2020) Adipocyte Specific Signaling. In: Silva J., Freitas M., Fardilha M. (eds) Tissue-Specific Cell Signaling. Springer, Cham. https://doi.org/10.1007/978-3-030-44436-5_15

2. Carrageta DF, Bernardino RL, Alves MG, Oliveira PF (2020)  CFTR regulation of aquaporin-mediated water transport. Vitamins and Hormones.  112:163-177. doi: 10.1016/bs.vh.2019.08.004  

1. Dias TR, Carrageta DF, Alves MG, Oliveira PF, Silva BM. Chapter 3.42 - White tea. In: Seyed Nabavi and Ana Silva (eds), Nonvitamin and Nonmineral Nutritional Supplements, 1st edition; 2019. p. 437-45, Academic Press, Elsevier. DOI: https://doi.org/10.1016/B978-0-12-812491-8.00058-8. ISBN: 9780128124918 

24. Madama, D.; Carrageta, D.F.; Guerra-Carvalho, B.; Botelho, M.F.; Oliveira, P.F.; Cordeiro, C.R.; Alves, M.G.; Abrantes, A.M. Impact of Different Treatment Regimens and Timeframes in the Plasmatic Metabolic Profiling of Patients with Lung Adenocarcinoma. Metabolites 2023, 13, 1180. https://doi.org/10.3390/metabo13121180

23. Carrageta DF, Freire-Brito L, Guerra-Carvalho B, Bernardino RL, Monteiro BS, Barros A., Oliveira PF, Monteiro MP, Alves MG. (2023). Mitochondrial uncoupling proteins regulate the metabolic function of human Sertoli cells. Reproduction (published online ahead of print 2023), REP-23-0229. Retrieved Dec 11, 2023, from https://doi.org/10.1530/REP-23-0229

22. Braga PC, Bernardino RL, Guerra-Carvalho B, Carrageta DF, Oliveira PF, Rodrigues AS, Alves MG. The progression from mild to severe hyperglycemia coupled with insulin resistance causes mitochondrial dysfunction and alters the metabolic secretome of epithelial kidney cells. Experimental Cell Research. 2023. 113744. https://doi.org/10.1016/j.yexcr.2023.113744

21. Morais T, Seabra AL, Patrício BG, Carrageta DF, Guimarães M, Nora M, Oliveira PF, Alves MG, Monteiro MP. Dysglycemia Shapes Visceral Adipose Tissue’s Response to GIP, GLP-1 and Glucagon in Individuals with Obesity. Metabolites. 2023; 13(5):587. https://doi.org/10.3390/metabo13050587

20. Carrageta DF, Freire-Brito L, Guerra-Carvalho B, Ribeiro JC, Monteiro BS, Barros A, Oliveira PF, Monteiro MP, Alves MG. Inhibition of Mitochondrial Uncoupling Proteins Arrests Human Spermatozoa Motility without Compromising Viability. Antioxidants. 2023; 12(2):409. https://doi.org/10.3390/antiox12020409

19. Ribeiro JC, Bernardino RL, Carrageta DF, Soveral G, Calamita G, Alves MG, Oliveira PF. CFTR modulates aquaporin-mediated glycerol permeability in mouse Sertoli cells. Cell Mol Life Sci. 2022 Nov 15;79(12):592. doi: 10.1007/s00018-022-04619-1. PMID: 36378343.

18. Silva R, Carrageta DF, Alves MG, Silva BM, Oliveira PF. Antioxidants and Male Infertility. Antioxidants 2022, 11, 1152. DOI: 10.3390/antiox11061152

17. Moreira S*, Silva R*, Carrageta DF*, Alves MG, Seco-Rovira V, Oliveira PF, Pereira ML. Carbamate Pesticides: Shedding Light on Their Impact on the Male Reproductive System. Int. J. Mol. Sci. 2022, 23(15), 8206. DOI: 10.3390/ijms23158206

*These authors contributed equally to this work.

16. Silva R, Carrageta DF, Alves MG, Oliveira PF. Testicular Glycogen Metabolism: An Overlooked Source of Energy for Spermatogenesis? BioChem. 2022, 2, 198-214. DOI: 10.3390/biochem2030014

15. Carrageta DF, Freire-Brito L, Oliveira PF, Alves MG. Evaluation of human spermatozoa mitochondrial membrane potential using the JC-1 dye. Current Protocols, 2, e531. DOI: 10.1002/cpz1.531

14. Carrageta DF*, Guerra-Carvalho B*, Spadella MA, Yeste M, Oliveira PF, Alves MG (2022) Animal models of male reproductive ageing to study testosterone production and spermatogenesis. Rev Endocr Metab Disord 2022. DOI: 10.1007/s11154-022-09726-9

13. Moreira MV, Pereira SC, Guerra-Carvalho B, Carrageta DF, Pinto S, Barros A, Silva BM, Oliveira PF, Alves MG (2022) Hyperoside Supplementation in Preservation Media Surpasses Vitamin C Protection Against Oxidative Stress-induced Damages in Human Spermatozoa. Cell Physiol Biochem 2022;56(S1):1-23. DOI: 10.33594/000000487

12. Ribeiro JC, Carrageta DF, Bernardino RL, Alves MG, Oliveira PF (2022) Aquaporins and Animal Gamete Cryopreservation: Advances and Future Challenges. Animals 12(3):359. DOI: 10.3390/ani12030359

11. Pereira PR, Carrageta DF, Oliveira PF, Rodrigues A, Alves MG, Monteiro MP (2022) Metabolomics as a tool for the early diagnosis and prognosis of diabetic kidney disease. Med Res Rev. 2022; 1-27. doi:10.1002/med.21883

10. Monteiro BS*, Freire-Brito L*, Carrageta DF, Oliveira PF, Alves MG (2021). Mitochondrial Uncoupling Proteins (UCPs) as Key Modulators of ROS Homeostasis: A Crosstalk between Diabesity and Male Infertility? Antioxidants, 10(11), 1746. doi:10.3390/antiox10111746

9. Guerra-Carvalho B*, Carrageta DF*, Crisóstomo L*, Carvalho RA, Alves MG, Oliveira PF (2021). Molecular mechanisms regulating spermatogenesis in vertebrates: Environmental, metabolic, and epigenetic factor effects. Animal reproduction science, 106896. doi:10.1016/j.anireprosci.2021.106896 

8. Carrageta DF, Guerra-Carvalho B, Sousa M, Barros A, Oliveira PF, Monteiro MP, Alves MG (2020) Mitochondrial Activation and Reactive Oxygen-Species Overproduction during Sperm Capacitation are Independent of Glucose Stimuli. Antioxidants, 9(8), 750. doi: 10.3390/antiox9080750

7. Pinto S*, Carrageta DF*, Alves MG, Rocha A, Agarwal A, Barros A, Oliveira PF (2020) Sperm selection strategies and their impact on assisted reproductive technology outcomes. Andrologia. e13725. doi:10.1111/and.13725

6. Carrageta DF, Oliveira PF, Alves MG, Monteiro MP (2019) Obesity and male hypogonadism: Tales of a vicious cycle. Obesity Reviews. 20: 1148– 1158. doi: 10.1111/obr.12863

5. Carrageta DF, Bernardino RL, Soveral G, Calamita G, Alves MG, Oliveira PF (2019) Aquaporins and male (in)fertility: Expression and role throughout the male reproductive tract. Archives of Biochemistry and Biophysics. doi:10.1016/j.abb.2019.108222

4. Bernardino RL, Carrageta DF, Sousa M, Alves MG, Oliveira PF. (2019) pH and male fertility: making sense on pH homeodynamics throughout the male reproductive tract. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-019-03170-w

3. Bernardino RL*, Carrageta DF*, Silva AM, Calamita G, Alves MG, Soveral G, Oliveira PF (2018) Estrogen modulates glycerol permeability in Sertoli cells through downregulation of Aquaporin-9. Cells 7(10):153. *Both authors contributed equally. DOI: https://doi.org/10.3390/cells7100153

2. Carrageta DF, Dias TR, Jarak I, Alves MG, Oliveira PF, Van der Walt MM, Terre’Blanche G, Monteiro MP, Silva BM (2018) 8-(3-phenylpropyl)-1,3,7-triethylxanthine is a synthetic caffeine substitute with stronger metabolic modulator activity. Toxicology In Vitro 53:114-120. DOI: https://doi.org/10.1016/j.tiv.2018.08.002

1. Carrageta DF, Dias TR, Alves MG, Oliveira PF, Monteiro MP, Silva BM (2018) Anti-obesity potential of natural methylxanthines. Journal of Functional Foods. 43:84-94. DOI: https://doi.org/10.1016/j.jff.2018.02.001

*The authors have contributed equally to the paper

15. Carrageta DF, Oliveira PF, Barros A, Monteiro MP, Alves MG. Production and glucose-dependent secretion of insulin by human spermatozoa. Human Reproduction, Volume 37, Issue Supplement 1, July 2022, deac107.100. DOI: 10.1093/humrep/deac107.100

14. Freire-Brito L, Carrageta DF, Monteiro BS, Guerra-Carvalho B, Barros A, Oliveira PF, Alves MG. Inhibition of mitochondrial uncoupling proteins (UCPs) impairs the motility of human spermatozoa. Eur J Clin Invest 52: 7-176 e13796. DOI: 10.1111/eci.13796

13. Carrageta DF, Freire-Brito L, Monteiro BS, Guerra-Carvalho B, Bernardino RL, Oliveira PF, Monteiro MP, Alves MG. Mitocondrial uncoupling proteins (UCPs) are metabolic modulators in human Sertoli cells. Eur J Clin Invest 52: 7-176 e13796. DOI: 10.1111/eci.13796

12. Freire-Brito L, Carrageta DF, Monteiro BS, Guerra-Carvalho B, Barros A, Oliveira, PF, Alves MG. Mitochondrial uncoupling proteins (UCPs) are key regulators of human spermatozoa motility. Endocrine Abstracts. 2022; 81 EP894. DOI: 10.1530/endoabs.81.EP894

11. Carrageta DF, Freire-Brito L, Monteiro BS, Guerra-Carvalho B, Bernardino RL, Oliveira PF, Monteiro MP, Alves MG. Mitochondrial uncoupling proteins (UCPs) regulate the mitochondrial activity of human sertoli cells. Endocrine Abstracts. 2022; 81 EP893. DOI: 10.1530/endoabs.81.EP893

10. Carrageta DF, Freire-Brito L, Monteiro BS, Guerra-Carvalho B, Bernardino RL, Oliveira, PF, Monteiro MP, Alves MG. Proteínas desacopladoras (UCPs) regulam o metabolismo da glucose em células de Sertoli humanas. Revista Portuguesa de Diabetes. 2022; 17 (1) Suppl: 46. ISSN: 1646-3994

9. Carrageta DF, Oliveira PF, Barros A, Monteiro MP, Alves MG. Glucose stimuli prompts insulin secretion by human spermatozoa. FEBS Open Bio. 2021; 11(S1), 181. DOI: 10.1002/2211-5463.13205

8. Carrageta DF, Oliveira PF, Barros A, Monteiro MP, Alves MG. Insulin production by human spermatozoa in response to glucose stimuli. Endocrine Abstracts. 2021; 73 PEP4.4. DOI: 10.1530/endoabs.73.PEP4.4

7. Carrageta DF, Oliveira PF, Barros A, Monteiro MP, Alves MG. O espermatozoide humano sintetiza e liberta insulina em resposta à glucose. Revista Portuguesa de Diabetes 2021; 16 (1) Suppl: p.50. ISSN: 1646-3994

6. Carrageta DF, Oliveira PF, Barros A, Sousa M, Monteiro MP, Alves MG. Is Hyperglycemia the trigger for Diabetes-related Male Infertility? Eur J Clin Invest, 50: e13369. DOI: 10.1111/eci.13369

5. Carrageta DF, Oliveira PF, Barros A, Sousa M, Monteiro MP, Alves MG. Hyperglycemia induces capacitation and ROS overproduction on human sperm. Obesity Reviews. 2020; 21(S1): e13118. DOI: 10.1111/obr.13118

4. Carrageta DF, Oliveira PF, Barros A, Sousa M, Monteiro MP, Alves MG. Hiperglicemia promove a capacitação e hiperativação mitocondrial em espermatozoides humanos. Revista Portuguesa de Diabetes 2020; 15 (1) Suppl: 94-107. ISSN: 1646-3994

3. Carrageta DF*, Bernardino RL*, Alves MG, Soveral G, Oliveira PF. Aquaglyceroporins Expression and Glycerol Permeability are modulated by Estradiol in Mouse Sertoli cells. Revista Cubana de Investigaciones Biomédicas, 2019; 38(5): e0178. *These authors contributed equally to this work. ISSN: 1561-3011

2. Carrageta DF*, Bernardino RL*, Alves MG, Soveral G, Oliveira PF. CFTR modulates aquaporin-mediated glycerol permeability in mouse sertoli cells. SEHIT 2019, Histol Histopathol 34 (Suppl. 1): S126. *These authors contributed equally to this work. DOI: 10.14670/HH-sehit19

1. Bernardino RL*, Carrageta DF*, Silva AM, Alves MG, Soveral G, Oliveira PF. Aquaglyceroporins expression and glycerol permeability are modulated by estradiol in mouse sertoli cells. SEHIT 2019, Histol Histopathol 34 (Suppl. 1): S125. *These authors contributed equally to this work. DOI: 10.14670/HH-sehit19

1. Epigenetics (ISSN: 1559-2308)