Almeida SP

Short Biography:

Susana de Almeida, completed her LSc degree in Aquatic Sciences (Marine Biology) in 1997. In 2009 she was conferred a MSc degree in Medicine and Molecular Oncology at the Faculty of Medicine, University of Porto (FMUP), Portugal. Presently, she is a PhD student at Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal under the supervision of Dr. Pedro F. Oliveira and co-supervision of Prof. Mário Sousa and Prof. Alberto Barros. Her research interests are in Aging, its impact on fertility, and in the male reproductive biology research field.

Ended funded projects:

“Envolvimento das mutações do gene da Hemocromatose (HFE) na Hemofilia”. Investigador responsável: Eugénia Cruz. Instituições: IBMC, HGSA, Porto (Serviço de Hematologia Clínica). Financiamento: Forum Hematológico do Norte (FHN)

“Genetics of Alzheimer Disease”. Investigador Principal: Graça Porto. Responsável Clínica: Ana Paula Correia., Instituições: IBMC, Hospital de Magalhães Lemos ; Financiamento: Lundbeck Portugal Lda.“HFE mutations and HLA polymorphisms: a population based study”. Investigador Investigador responsável: Graça Porto. Instituições: IBMC, HGSA, Porto (Serviço de Hematologia Clínica) Financiamento: FCT - POCTI/32986/MGI/2000:

Fellowships and Prizes:

2018 – FEBS Congress Grant to attend and present a poster at the 43rd FEBS Congress, 7-12 July 2018, Prague, Czech Republic.

2015 - 4-year PhD fellowship from the Portuguese Foundation for Science and Technology (FCT).

Proceedings in Peer-reviewed Journals:

1. Dias TR, Alves MG, Almeida SP, Silva J, Barros A, Sousa M, Silva BM, Silvestre SM, Oliveira PF (2016) "Modulation of human Sertoli cells metabolism by precursors of androgen synthesis: new insights on the role of dehydroepiandrosterone and 7-oxo-dehydroepiandrosterone". 50th Annual Scientific Meeting of the European Society for Clinical Investigation in European Journal of Clinical Investigation. 46(S1):121. ISSN: 1365-2362

Book chapters:

1. Almeida SP, Rato L (2017) Biochemical Changes in the Reproductive Function of the Aging Male. In: Alves MG, Oliveira PF (eds) Biochemistry of Andrology, vol 1. Andrology: Current and Future Developments. Bentham Science Publishers, Sharjah, UAE, pp 389-411. ISBN: 978-1-68108-501-2

Publications:

12. Jarak I, Almeida SP, Carvalho RA, Sousa M, Barros A, Alves MG, Oliveira PF (2018) Senescence and declining reproductive potential: Insight into molecular mechanisms through testicular metabolomics. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. DOI: https://doi.org/10.1016/j.bbadis.2018.07.028

11. Almeida SP, Rato L, Sousa M, Alves MG, Oliveira PF (2017) Fertility and sperm quality in the aging male. Current Pharmaceutical Design. 23(46): 1-1. (DOI:10.2174/1381612823666170503150313)

10. Almeida SP, Alves MG, Sousa M, Oliveira PF, Silva BM (2016) Are polyphenols strong dietary agents against neurotoxicity and neurodegeneration? Neurotoxicity Research. 30(3): 345-366. (DOI 10.1007/s12640-015-9590-4)

9. Dias TR, Alves MG, Almeida SP, Silva J, Barros A, Sousa M, Silva BM, Silvestre SM, Oliveira PF (2015) Dehydroepiandrosterone and 7-oxo- dehydroepiandrosterone in male reproductive health: implications of differential regulation of human Sertoli cells metabolic profile. J. Steroid Biochem. Mol. Biol. 154:1-11 (doi:10.1016/j.jsbmb.2015.06.004).

8. Correia AP, Pinto JP, Dias V, Mascarenhas C, Almeida S, Porto G (2009) CAT53 and HFE alleles in Alzheimer's disease: a putative protective role of the C282Y HFE mutation. Neurosci Lett. 457(3):129-32.

7. Beirão I, Almeida S, Swinkels D, Costa PM, Moreira L, Fonseca I, Freitas C, Cabrita A, Porto G (2008) Low serum levels of prohepcidin, but not hepcidin-25, are related to anemia in familial amyloidosis TTR V30M. Blood Cells Mol Dis. 41:175-82.

6. Vieira J, Cardoso CS, PintoJ, Patil K, Brazdil P, Cruz E, Mascarenhas C, Lacerda R, Gartner A, Almeida S, Alves H and Porto G (2007) A putative gene located at the MHC-class I region around the D6S105 marker contributes to the setting of CD8+ T lymphocyte numbers in humans. Int J Immunogenet; 34:359-367

5. Cardoso CS, Araújo H, Cruz E, Afonso A, Mascarenhas C, Almeida S, Moutinho J, Lopes C, Medeiros R (2006) Haemochromatosis gene (HFE) mutations in viral-associated neoplasia: Linkage to cervical cancer. BBRC; 341: 232-238

4. Cruz E, Vieira E, Almeida S, Lacerda R, Gartner A, Cardoso CS, Alves H and Porto G. (2006) A study of 82 extended HLA haplotypes in HFE-C282Y homozygous hemochromatosis subjects: relationship to the genetic control of CD8+ T-lymphocyte numbers and severity of iron overload. BMC Medical Genetics 7:16

3. Cruz E, Melo G, Lacerda R, Almeida S, Porto G. (2006) The CD8+ T-Lymphocyte profile as a modifier of iron overload in HFE hemochromtosis: An update of clinical and immunological data from 70 C282Y Homozygous subjects. BloodCells, Molecules &Diseases 37 (2006) 33-39.

2. Porto G, Roetto A, Daraio F, Pinto JP, Almeida S, Bacelar C, Nemeth E, Ganz T and Camaschella C. (2005) A Portuguese patient homozygous for the -25G>A mutation of the HAMP promoter shows evidence of steady-state Transcription but fails to up-regulate hepcidin levels by iron. Blood, volume 106:2922-3.

1. Cruz E, Vieira J, Gonçalves R, Alves H, Almeida S, Rodrigues P, Lacerda R, Porto G (2004) Involvement of the major histocompatibility complex region in the genetic Regulation of circulation CD8 T – Cell numbers in humans.”Tissue Antigens. 64(1):25 – 34