Martins AD
Short Biography
Ana D. Martins completed her PhD in Biomedical Sciences at the Institute of Biomedical Sciences Abel Salazar, University of Porto in January 2020. Her LSc and MSc degrees in Biomedical Sciences were completed at the University of Beira Interior in 2011 and 2012, respectively. From 2012 to 2015 she was laboratory technician at the Health Sciences Research Center, University of Beira Interior, Covilhã, Portugal under the supervision of Dr. Pedro F. Oliveira, within the founded project: PTDC/QUI-BIQ/121446/2010. In 2015, she started her PhD under the supervision of Dr. Marco G. Alves (CICS-UBI), and co-supervision of Prof. Mário Sousa (UMIB-ICBAS/UP) and Prof. Rui A. Carvalho (CNC-FCT/UC), with the title: Hormonal regulation of spermatogenesis: role of ghrelin leptin axis and glucagon-like peptide-1 in nutrient membrane transport through Sertoli cell/blood-testis barrier concluded this year.
Currently she is a post-doc fellow within the project: Spermboost - Improving sperm preparation and cryopreservation for Assisted Reproductive Technologies at Institute of Biomedical Sciences Abel Salazar - University of Porto.
Since 2012 she published 39 articles in journals, 4 sections of books, organized 7 events and participated in other 36 events. She participates and/or participated in three founded projects (FCT - PTDC/QUI-BIQ/121446/2010; PTDC/BIM-MET/4712/2014; PTDC/MEC-AND/28691/2017). She had also awarded a Fulbright Fellow in 2017 at Cleveland Clinic, USA under the supervision of Dr. Ashok Agarwal.
Her research interests are cell hormonal control, cell metabolism and metabolic modulation, particularly in male reproductive system. Her main research keywords are: spermatogenesis; male (in)fertility; Sertoli cell; glucose metabolism; hormonal regulation; metabolic diseases; obesity; metabolism.
Funded projects
PTDC/MEC-AND/28691/2017: “TRAITor - Tracking TRAnsgenerational epigenetic Inheritance of metabolic diseases Transmitted via overweight or obese fathers”. P.I.: Marco G Alves
PTDC/BIM-MET/4712/2014: “Obesitility – Gut hormones and testicular metabolism: mechanisms associated with obesity-related male infertility”. P.I.: Marco G Alves
Spermboost: improving sperm preparation and cryopreservation for Assisted Reproductive Technologies”, P.I.: Marco G Alves by Merck®
Ended funded projects
PTDC/QUI-BIQ/121446/2010:“Can Hormonal (De)regulation of Ion Transporters in Human Sertoli Cells be Responsible for Infertility?” - P.I.: Pedro Fontes Oliveira.
Fellowships and Prizes
20222 - Stimulus for Scientific Employment with the project: "No Fertility for Old Men - Identification of spermatozoa and seminal plasma biomarkers for capacitation in aging using a proteomic approach"
2020 - Post-Doctoral fellow in the project “Spermboost: Improving Sperm Preparation and Cryopreservation for Assisted Reproductive Technologies”
2019 - Travel grant to attend the Molecular Andrology 2019 symposium at the Justus Liebig University, Giessen, Germany, 24-26 September 2019.
2018 - Travel grant to attend the ICDM 2018, held from 11-13 October, at the Grand Hilton Hotel Seoul, Seoul, South Korea.
2018 - Fellowship to participate at the MiPschool Tromsø-Bergen, 20-24 October, Hurtigruten: Tromsø - Bergen, Norway.
2017 - Fellowship to participate at the 17th FEBS Young Scientists’ Forum and at the 42nd FEBS congress. 7-14 September 2017, Jerusalem, Israel.
2017 - Fulbright research scholarship with the support from the Portuguese Foundation for Science and Technology (FCT) for the academic year 2017/2018.
2016 - Fellowship to participate in the 2nd International Workshop on Klinefelter Syndrome. 10-12 March, 2016, Munster, Germany.
2015 - 4-year PhD fellowship from the Portuguese Foundation for Science and Technology (FCT).
2015 - Fellowship from the ISMAR - International Society of Magnetic Resonance to participate in the ISMAR 2015 Conference. August 16-21, Shanghai, China
2015 - Fellowship to participate in the 40th Congress of The Federation of European Biochemical Societies (FEBS). July 4-9, Berlin, Germany
2012 - Research fellow in the project: “Can Hormonal (De)regulation of Ion Transporters in Human Sertoli Cells be Responsible for Infertility?”
Proceedings in Peer-reviewed Journals
13. Martins AD, Moreira AC, Sá R, Monteiro MP, Sousa M, Carvalho RA, Silva BM, Oliveira PF, Alves MG (2016). Ação da leptina no metabolismo da glucose das células de Sertoli: impacto na fertilidade masculina. CAPTAR. 6(1): 43 – 44. ISSN:1647-323X
12. Jesus TT, Bernardino RL, Martins AD, Sá R, Sousa M, Alves MG, Oliveira PF (2016) As aquaporinas-4 e -9 são expressas em células de Sertoli de rato e interagem com o CFTR. CAPTAR. 6(1):38-9. ISSN:1647-323X
11. Dias TR, Alves MG, Bernardino RL, Martins AD, Moreira AC, Silva J, Barros A, Sousa M, Silva BM, Oliveira PF (2016) Caffeine and male fertility: Metabolic effects and oxidative profile in human Sertoli cells. CAPTAR. 6(1): 28 – 29. ISSN:1647-323X
10. Bernardino RL, Martins AD, Costa AR, Silva J, Barros A, Sousa M, Alves MG, Oliveira PF (2016) Influência do estradiol nos transportadores membranares de bicarbonato dependentes de sódio da família SLC4 em células de Sertoli humanas. CAPTAR. 6(1): 4 – 6. ISSN:1647-323X
9. Pinto S, Martins AD, Moreira PI, Carvalho RA, Sousa M, Barros A, Silva J, Simões T, Oliveira PF, Alves MG (2015) Metabolic fingerprints in testicular biopsies from type 1 diabetic patients. Hum Reprod 30(Suppl. 1):170.
8. Alves MG, Bernardino RL, Martins AD., Jesus TT, Sousa M, Sá R, Oliveira PF (2015) Estrogenic regulation of bicarbonate transporters from SLC4 family in rat Sertoli cells. Human Reproduction. 30(Suppl. 1):161.
7. Martins AD, Sá R, Monteiro MP, Barros A, Silva J, Sousa M, Carvalho RA, Silva BM, Oliveira PF, Alves MG (2015). Ghrelin modulates human Sertoli cells metabolism: relevance for male fertility. FEBS J. 282 (Suppl. 1) 55: 188.
6. Bernardino RL, Martins AD, Costa AR, Silva J, Barros A, Sá R, Sousa M, Alves MG, Oliveira PF (2015). Estrogenic regulation of Na+-dependent bicarbonate transporters from SLC4 family in human Sertoli Cells. FEBS J. 282 (Suppl. 1) 55: 199.
5. Dias TR, Alves MG, Bernardino RL, Martins AD, Moreira AC, Silva J, Barros A, M. Sousa, Silva BM, Oliveira PF (2015). Caffeine-induced alterations in human Sertoli cells metabolism and oxidative profile. FEBS J. 282 (Suppl. 1) 55: 386.
4. Correia S, Alves MR, Martins AD, Cavaco JE, Oliveira PF, Socorro S (2014) Effect of 17b-estradiol on germ cell apoptosis by modulating the expression of SCF/c-kit, FasL/FasR and regucalcin. Endocrine Abstracts 35: P702. (DOI: 10.1530/endoabs.35.P702).
3. Alves MG*, Jesus TT*, Bernardino RL, Martins AD, Sá R, Sousa M, Oliveira PF (2013) Water transport in seminiferous tubule: aquaporins identification in Sertoli cells. Proc. 37th IUPS, LB91
2. Bernardino RL, Martins AD, Jesus TT, Sá R, Sousa M, Socorro S, Alves MG, Oliveira PF (2013) Regulation by estrogens of bicarbonate secretion mechanisms in Sertoli cell. Proc. 37th IUPS, LB113.
1. Martins AD, Simões VL, Alves MG, Cavaco JE, Socorro S, Oliveira PF (2012) Hormonal Regulation of Na+H+ Exchanger 3 (NHE3) in Sertoli Cells: A Possible Role for Estrogens in Spermatogenesis. J. Reproduktionsmed. Endokrinol. 9(5): 371.
Book chapters
Publications
45. Silva JV, Santiago J, Matos B, Henriques MC, Patrício D, Martins AD, Duarte JA, Ferreira R, Alves MG, Oliveira P, Oliveira PF, Fardilha M. Effects of Age and Lifelong Moderate-Intensity Exercise Training on Rats' Testicular Function. Int J Mol Sci. 2022 Oct 1;23(19):11619. doi: 10.3390/ijms231911619
43. Ribeiro, J.C.; Martins, A.D.; Jarak, I.; Carvalho, R.A.; Alves, M.G.; Oliveira, P.F. (2022) Exenatide and Dapagliflozin Combination Enhances Sertoli Cell Secretion of Key Metabolites for Spermatogenesis. Biomedicines, 10, 1115. doi: 10.3390/biomedicines10051115
30. Martins AD, Agarwal A (2019). Oxidation reduction potential: a new biomarker of male infertility. Panminerva Medica, Jun;61(2):108-117. DOI:10.23736/S0031-0808.18.03529-2
8. Dias TR, Martins AD, Reis VP, Socorro S, Silva BM, Alves MG, Oliveira PF (2013) Glucose transport and metabolism in Sertoli cell: relevance for male fertility. Cur. Chem. Biol. 7(3):282-93. (DOI: 10.2174/2212796807999131128125510)
7. Bernardino RL, Martins AD, Socorro S, Alves MG, Oliveira PF (2013) Effect of pre-diabetes on membrane bicarbonate transporters in testis and epididymis. J. Memb. Biol. 246(12):877-83 (DOI:10.1007/s00232-013-9601-4)
* both authors contributed equally