Mitchelton station opened in 1918 when the line was extended from Enoggera to Samford and it was extended again to Dayboro in 1920 which was truncated to Ferny Grove in 1955. The line was duplicated in 2008 to Keperra.
Mitchelton was named after the homonymous suburb which was named after the family that were the first settlers in the area who emigrated from England in the 1850s.
Mitchelton station has two platforms consisting of an island platform. Platform 1 is for inbound services and 2 is for outbound services. To the north of the station there is a turnback siding.
Mitchelton station has two station entrances. One is from McConaghy Street and the other is from the carpark on Kedron Avenue.
Mitchelton station does have disability access.
There is a bus interchange outside the station on McConaghy Street serving nearby suburbs. The routes that serve Mitchelton are routes 359, 369, 390, 396, 397 and 398. There are many other bus services departing from Brookside Shopping Centre nearby.