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cAMP signalling in mycobacteria
cAMP signalling in mycobacteria
Mycobacteria are endowed with a number of genes involved in cyclic AMP metabolism. Beginning with bioinformatic analysis, we have characterized a number of novel genes in mycobacteria, including adenylyl cyclases, phosphodiesterases and cyclic nucleotide binding proteins. Of importance is the identification for the first time of a cAMP-regulated protein acyl transferase encoded in Mycobacterial genomes and substrates for this unique regulatory enzyme. Moonlighting tasks of a cAMP phosphodiesterase has also been studied extensively, as has a cAMP-binding universal stress protein. These students have been coupled with strucural elucidation of these proteins working with collaborators in India and around the world.
Mycobacteria are endowed with a number of genes involved in cyclic AMP metabolism. Beginning with bioinformatic analysis, we have characterized a number of novel genes in mycobacteria, including adenylyl cyclases, phosphodiesterases and cyclic nucleotide binding proteins. Of importance is the identification for the first time of a cAMP-regulated protein acyl transferase encoded in Mycobacterial genomes and substrates for this unique regulatory enzyme. Moonlighting tasks of a cAMP phosphodiesterase has also been studied extensively, as has a cAMP-binding universal stress protein. These students have been coupled with strucural elucidation of these proteins working with collaborators in India and around the world.
Important Publications
Important Publications
Zaveri A, Bose A, Sharma S, Rajendran A, Biswas P, Shenoy AR, Visweswariah SS. (2021) Mycobacterial STAND adenylyl cyclases: The HTH domain binds DNA to form biocrystallized nucleoids. Biophys. J. doi: 10.1016/j.bpj.2020.11.008.
Zaveri A, Bose A, Sharma S, Rajendran A, Biswas P, Shenoy AR, Visweswariah SS. (2021) Mycobacterial STAND adenylyl cyclases: The HTH domain binds DNA to form biocrystallized nucleoids. Biophys. J. doi: 10.1016/j.bpj.2020.11.008.
Samanta S, Biswas P, Banerjee A, Bose A, Siddiqui N, Nambi S, Saini DK, Visweswariah SS (2020) A universal stress protein in Mycobacterium smegmatis sequesters the cAMP-regulated lysine acyltransferase and is essential for biofilm formation. J Biol Chem. 295(6):1500-1516. doi: 10.1074/jbc.RA119.011373.
Samanta S, Biswas P, Banerjee A, Bose A, Siddiqui N, Nambi S, Saini DK, Visweswariah SS (2020) A universal stress protein in Mycobacterium smegmatis sequesters the cAMP-regulated lysine acyltransferase and is essential for biofilm formation. J Biol Chem. 295(6):1500-1516. doi: 10.1074/jbc.RA119.011373.
Samanta,S, Singh A, Biswas, P, Bhatt, A and Visweswariah SS (2017) Mycobacterial phenolic glycolipid synthesis is regulated by cAMP-dependent lysine acylation of FadD22 Microbiology 163: 373-382
Samanta,S, Singh A, Biswas, P, Bhatt, A and Visweswariah SS (2017) Mycobacterial phenolic glycolipid synthesis is regulated by cAMP-dependent lysine acylation of FadD22 Microbiology 163: 373-382
Visweswariah, S.S. and Busby, S.J. (2015) Evolution of bacterial transcription factors: how proteins take on new tasks, but do not always stop doing the old ones. Trends Microbiol. 23: 463-467.
Visweswariah, S.S. and Busby, S.J. (2015) Evolution of bacterial transcription factors: how proteins take on new tasks, but do not always stop doing the old ones. Trends Microbiol. 23: 463-467.
Banerjee, A., Adolph, R.S., Gopalakrishnapai, J., Kleinboetling, S., Emmerich, C., Steegborn, C. and Visweswariah, S.S. (2015) A universal stress protein (USP) in Mycobacteria binds cAMP. J. Biol. Chem. 290: 12731-12743.
Banerjee, A., Adolph, R.S., Gopalakrishnapai, J., Kleinboetling, S., Emmerich, C., Steegborn, C. and Visweswariah, S.S. (2015) A universal stress protein (USP) in Mycobacteria binds cAMP. J. Biol. Chem. 290: 12731-12743.
Matange, N., Podobnik, R. and Visweswariah, S.S. (2015) Metallophosphoesterases: structural similarity with functional promiscuity. Biochem. J. 467: 201-216.
Matange, N., Podobnik, R. and Visweswariah, S.S. (2015) Metallophosphoesterases: structural similarity with functional promiscuity. Biochem. J. 467: 201-216.
Matange, N., Podobnik, M., Visweswariah. S.S. (2014) The non-catalytic "cap domain" of a mycobacterial metallophosphoesterase regulates its expression and localization in the cell. J. Biol. Chem. 289: 22470-22481.
Matange, N., Podobnik, M., Visweswariah. S.S. (2014) The non-catalytic "cap domain" of a mycobacterial metallophosphoesterase regulates its expression and localization in the cell. J. Biol. Chem. 289: 22470-22481.
Podobink, M., Siddiqui, N., Rebolj, K., Nambi, S., Merzel, F. and Visweswariah, S.S. (2014) Allostery and conformational dynamics in cAMP-regulated acyltransferases. J. Biol. Chem. 289: 16588–16600.
Podobink, M., Siddiqui, N., Rebolj, K., Nambi, S., Merzel, F. and Visweswariah, S.S. (2014) Allostery and conformational dynamics in cAMP-regulated acyltransferases. J. Biol. Chem. 289: 16588–16600.
Nambi, S., Gupta, K., Bhattacharya, M., Ramakrishnan, P., Ravikumar, V., Siddiqui, N., Thomas, A.T. and Visweswariah, S.S. (2013) Cyclic AMP-dependent protein lysine acylation in mycobacteria regulates fatty acid and propionate metabolism. J. Biol. Chem. 288: 14114-14124.
Nambi, S., Gupta, K., Bhattacharya, M., Ramakrishnan, P., Ravikumar, V., Siddiqui, N., Thomas, A.T. and Visweswariah, S.S. (2013) Cyclic AMP-dependent protein lysine acylation in mycobacteria regulates fatty acid and propionate metabolism. J. Biol. Chem. 288: 14114-14124.
Nambi, S., Basu, N. and Visweswariah, S. S.(2010) Cyclic AMP-regulated protein lysine acetyl transferases in Mycobacteria. J. Biol. Chem. 285: 24313-24322
Nambi, S., Basu, N. and Visweswariah, S. S.(2010) Cyclic AMP-regulated protein lysine acetyl transferases in Mycobacteria. J. Biol. Chem. 285: 24313-24322
Shenoy, A.R. and Visweswariah, S.S.(2006) New Messages from Old Messengers: cAMP and Mycobacteria. Trends Microbiol. 14: 543-550.
Shenoy, A.R. and Visweswariah, S.S.(2006) New Messages from Old Messengers: cAMP and Mycobacteria. Trends Microbiol. 14: 543-550.
Shenoy, A.R. and Visweswariah, S.S.(2006) Mycobacterial adenylyl cyclases: Biochemical diversity and structural plasticity. FEBS Letters 580: 3344-3354.
Shenoy, A.R. and Visweswariah, S.S.(2006) Mycobacterial adenylyl cyclases: Biochemical diversity and structural plasticity. FEBS Letters 580: 3344-3354.
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