High-Yield COMLEX Concepts

🦴 1. OMM & Chapman Points

• Fryette mechanics (Type I vs II)
  
  

• Chapman's points (breast, colon, sinus, prostate)
  
  

• Viscerosomatic reflexes (e.g. heart T1–T5, lungs T2–T7)
  
  

• Sacral diagnoses, cranial strain patterns (torsion, vertical strain)
  
  

• Common SD findings in clinical scenarios
  
  

❤️ 2. Cardiology

• Murmur changes with maneuvers (especially HCM vs AS)
  
  

• EKG interpretation basics (esp. 3rd-degree AV block, AFib, PE)
  
  

• Heart failure types, JVP waves, & PCWP interpretation
  
  

• Endocarditis bugs + empiric tx
  
  

🧠 3. Neurology

• Spinal cord syndromes (Brown-Séquard, ASA, PSA)
  
  

• CN lesions, facial droop vs stroke
  
  

• Parkinson’s vs essential tremor
  
  

• Myasthenia vs Lambert-Eaton vs Botulism
  
  

🦠 4. Microbiology + Immuno

• Bugs with buzzwords (e.g., “safety pin = Yersinia,” “cold agglutinins = Mycoplasma”)
  
  

• Vaccines: live vs killed, schedule
  
  

• Hypersensitivity types (I–IV), complement deficiencies
  
  

• TORCH infections
  
  

🩺 5. Ethics / Legal

• Capacity vs competence
  
  

• Advanced directives, surrogate decision-makers
  
  

• Child abuse, elder abuse, domestic violence red flags
  
  

• Mandatory reporting laws
  
  

🫁 6. Pulm

• Lung volume loops (obstructive vs restrictive)
  
  

• COPD vs asthma: path, labs, tx
  
  

• PE: signs, ABG, EKG (S1Q3T3)
  
  

• Sleep apnea: OSA vs CSA
  
  

🧪 7. Renal & Acid/Base

• RTA types I–IV
  
  

• Nephritic vs nephrotic
  
  

• AG vs NAG metabolic acidosis
  
  

• FENa, urine Na interpretation
  
  

🔥 8. Endocrine

• DKA vs HHS
  
  

• Thyroid testing patterns
  
  

• Adrenal insufficiency vs Cushing’s
  
  

• Calcium, PTH, Vit D axis + phosphate disorders
  
  

🧬 9. Repro

• Amenorrhea workup (FSH, LH, prolactin)
  
  

• PCOS vs CAH vs AIS
  
  

• Breast mass workup
  
  

• OCP contraindications
  
  

🩸 10. Heme/Onc

• Microcytic vs macrocytic vs normocytic anemia
  
  

• Hemolysis labs
  
  

• Leukemia ages & translocations
  
  

• TTP vs HUS vs DIC
  
  

🦴 11. MSK + Rheum

• SLE vs RA vs Sjögren’s vs MCTD
  
  

• Seronegative spondyloarthropathies
  
  

• Gout vs pseudogout
  
  

• OA vs RA (PIP/DIP/MCP)
  
  

👶 12. Pediatrics

• Milestones (gross, fine, social, language)
  
  

• Vaccination schedule
  
  

• Congenital heart defects
  
  

• Genetic syndromes (Down, Turner, Fragile X)
  
  

🧠 13. Psych

• Depression vs grief vs adjustment disorder
  
  

• Schizophrenia spectrum + time cutoffs
  
  

• ADHD tx
  
  

• Defense mechanisms
  
  

🧫 14. Pathology Patterns

• Apoptosis vs necrosis
  
  

• Inflammation: acute vs chronic
  
  

• Neoplasia: oncogenes vs tumor suppressors
  
  

💊 15. Pharmacology

• Autonomic drugs (sympathetic/parasympathetic mnemonics)
  
  

• Antiarrhythmics (Class I–IV)
  
  

• Antibiotics (MOA, SEs)
  
  

• Diuretics (loops lose Ca, thiazides save Ca)
  
  

💀 16. Biostats/Epi

• Sensitivity, specificity, PPV, NPV
  
  

• RR, OR, ARR, NNT, NNH
  
  

• Study types + biases
  
  

🧬 17. Genetics

• Inheritance patterns
  
  

• Trinucleotide repeat diseases
  
  

• Chromosome microdeletion syndromes
  
  

🦠 18. GI

• Hepatitis serologie
  
  

• Inflammatory bowel disease differences
  
  

• Liver function test interpretation
  
  

🫀 19. Physiology Integration

• Starling forces
  
  

• RAAS system
  
  

• Cardiac & vascular pressure-volume loops
  
  

⚖️ 20. OMS-Specific Integration

• Treat SD that interferes with diagnosis (e.g., rib dysfunction + pulm issue)