PUBLICATIONS

Submitted

1. Po-Yi Lee, Gosia A. Fryc, John Gnalian, Yi Hua, Susannah Waxman, Fuqiang Zhong, Bin Yang, Ian A. Sigal. Direct measurements of collagen fiber recruitment in the posterior pole of the eye. Acta Biomaterialia. DOI: 10.1101/2023.05.07.539784

2. Fengting Ji, Marissa Quinn, Yi Hua, Po-Yi Lee, Ian A. Sigal. 2D or not 2D? Mapping the in-depth inclination of the collagen fibers of the corneoscleral shell. Experimental Eye Research.

Published 

3. Po-Yi Lee, Hannah Schilpp, Nathan Naylor, Simon C. Watkins, Bin Yang, Ian A Sigal. Stretch-induced collagen fiber recruitment in the posterior pole of the eye. Instant polarized light microscopy pi (IPOLπ) for quantitative imaging of collagen architecture and dynamics in ocular tissues. Optics and Lasers in Engineering, 166, 107594, July 2023. DOI: 10.1016/j.optlaseng.2023.107594

4. Ning-Jiun Jan*, Po-Yi Lee*, Jacob Wallace, Michael Iasella, Alexandra Gogola, Bingrui Wang, Ian A. Sigal. Stretch-induced uncrimping of equatorial sclera collagen Bundles. ASME Journal of Biomechanical Engineering, 145(5), 054503, May 2023. DOI: 10.1115/1.4056354 (* Authors contributed equally to this manuscript.)

5. Yi Hua, Yuankai Lu, Jason Walker, Po-Yi Lee, Haiden McDonald, Pedro Pallares, Fengting Ji, Bryn L. Brazile, Bin Yang, Andrew P. Voorhees, Ian A. Sigal. Eye-specific 3D modeling of factors influencing the minimum oxygen concentration in the lamina cribrosa, Experimental Eye Research, 220, 109105, July 2022. DOI: 10.1016/j.exer.2022.109105

6. Po-Yi Lee, Bin Yang, Yi Hua, Susannah Waxman, Ziyi Zhu, Fengting Ji, Ian A Sigal. Real-time imaging of optic nerve head collagen microstructure and biomechanics. Experimental Eye Research, 217, 109867, April 2022. DOI: 10.1016/j.exer.2022.108967

7. Po-Yi Lee, Yi Hua, Bryn L. Brazile, Bin Yang, Lin Wang, Ian A. Sigal. A workflow for 3D reconstruction and quantification of the monkey optic nerve head vascular network. Journal of Biomechanical Engineering, 144(1), March 2022. DOI: 10.1115/1.4054056

8. Susannah Waxman, Bryn L. Brazile, Bin Yang, Alexandra L. Gogola, Yi Hua, Po Lam, Po-Yi Lee, Andrew P. Voorhees, Joseph F. Rizzo III, Tatjana C. Jakobs, Ian A. Sigal. Lamina cribrosa vessel and collagen beam networks are distinct. Experimental Eye Research, 215, 108916, February 2022. DOI: 10.1016/j.exer.2021.108916

9. Bin Yang, Po‐Yi Lee, Yi Hua, Bryn Brazile, Susannah Waxman, Fengting Ji, Ziyi Zhu, Ian A. Sigal. Instant polarized light microscopy for imaging collagen microarchitecture and dynamics. Journal of Biophotonics, e202000326, October 2020. DOI: 10.1002/jbio.202000326

10. Yun-Chi Tsai, Wei-Chun Tang, Christine Siok Lan Low, Yen-Ting Liu, Jyun-Sian Wu, Po-Yi Lee, Yi-Ling Lin, Pakorn Kanchanawong, Liang Gao, Lindsay Chen, Bi-Chang Chen. Rapid high resolution 3D imaging of expanded biological specimens with lattice light sheet microscopy. Methods, 174, 11-19, March 2020. DOI: 10.1016/j.ymeth.2019.04.006

11. Xiaofei Bai, Michael Melesse, Christopher G. Sorensen Turpin, Dillon Sloan, Chin-Yi Chen, Wen-Cheng Wang, Po-Yi Lee, James R. Simmons, Benjamin Nebenfuehr, Diana Mitchell, Lindsey R. Klebanow, Nicholas Mattson, Eric Betzig, Bi-Chang Chen, Dhanya Cheerambathur, Joshua N. Bembenek. Aurora B functions at the apical surface after specialized cytokinesis during morphogenesis in C. elegans. Development, 147(1), January 2020. DOI: 10.1242/dev.181099

12. Chin-Yi Chen, Yen-Ting Liu, Chieh-Han Lu, Po-Yi Lee, Yun-Chi Tsai, Jyun-Sian Wu, Peilin Chen, Bi-Chang Chen. The applications of lattice light-sheet microscopy for functional volumetric imaging of hippocampal neurons in a three-dimensional culture system. Micromachines, 10(9), 599, September 2019. DOI: 10.3390/mi10090599

In Press

1. Po-Yi Lee, Bin Yang, Ian A. Sigal. Polarization Microscopy. Optical Elastography: Optical Techniques for Assessing Cell and Tissue Biomechanics. 

1. Yuankai Lu, Yi Hua, Bingrui Wang, Fuqiang Zhong, Andrew Theophanous, Shaharoz Tahir, Po-Yi Lee, Ian A. Sigal. Eye-specific modeling of effects of intraocular pressure on optic nerve head oxygenation. Proceedings of Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C), 664-45, June 2023. [PDF]

2. Po-Yi Lee, Jason Walker, Yi Hua, Bryn Brazile, Ian A. Sigal. Integrating capillary flow modeling and geometric quantification into reconstructed 3d capillary networks of the optic nerve head. Proceedings of Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C), 241-42, June 2021. [PDF]

3. Yi Hua, Jason Walker, Po-Yi Lee, Fengting Ji, Haiden McDonald, Pedro Pallares, Bryn Brazille, Ian A. Sigal. Factors influencing minimum lamina cribrosa oxygen concentration. Proceedings of Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C), 687-88, June 2021. [PDF]

4. Grace Ingram, Po-Yi Lee, Benjamin Bernarding, Ian A. Sigal, Bin Yang. Real-time structured polarized light imaging of dynamics of thick collagenous tissues. Proceedings of SPIE – Emerging Digital Micromirror Device Based Systems and Applications XIII 2021, 11698, 116980A, March 2021. [PDF]

5. Po-Yi Lee, Bin Yang, Gosia Fryc, Yi Hua, Ian A. Sigal. Direct visualization and measurement of stretch-induced uncrimping of the collagen fibers of the optic nerve head. Proceedings of Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C) 2020, 1032-33, June 2020. [PDF]

6. Bingrui Wang, Po-Yi Lee, Bin Yang, Fengting Ji, Ziyi Zhu, Yi Hua, Ian A. Sigal. Tissue collagen fibers are often interwoven. so what? in support of considering fiber interweaving. Proceedings of Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C), 1042-43, June 2020. [PDF]

7. Po-Yi Lee, Bin Yang, Yi Hua, Bryn Brazile, Fengting Ji, Ziyi Zhu, Gosia A. Fryc, Ian A. Sigal. Instant polarized light microscopy for real-time wide-field visualization of collagen architecture. Proceedings of SPIE – Label-free Biomedical Imaging and Sensing 2020, 112510Y, March 2020. [PDF]

8. Po-Yi Lee, Bin Yang, Ian A. Sigal. Real-time measurement of collagen architecture and deformations at sub-micron resolution. Proceedings of Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C) 2019, 341-42, June 2019. [PDF]

9. Bin Yang, Po-Yi Lee, Bryn Brazile, Ian A. Sigal. Snapshot-polarized light microscopy to visualize and quantify collagenous soft tissue microstructure at 156 frames/second. Proceedings of Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C), 202-03, June 2019. [PDF]

10. Po-Yi Lee, Wei-Wen Liu, Shu-Ching Chen, Pai-Chi Li. Dual-wavelength optical-resolution photoacoustic microscopy for cells with gold nanoparticle bioconjugates in three-dimensional cultures. Proceedings of SPIE –  Photons Plus Ultrasound: Imaging and Sensing 2016, 97081N, March 2016. [PDF]