Epilepsy Surgery

For many patients with epilepsy, surgery can be an effective treatment with around 50-70% of patients achieving seizure freedom following surgery. However, for those remaining patients, seizures still continue even after invasive surgery. We investigated this by using patient data to constrain parameters in a computer model, which then underwent a 'simulated surgery'. Such a model simulated seizure rates after surgery, which predict patient outcomes with 81% accuracy [1].

Example Publications

1. Taylor, P.N., Sinha, N., Wang, Y., Vos, S.B., de Tisi, J., Miserocchi, A., McEvoy, A.W., Winston, G.P.†, Duncan, J.S.†, 2018, The impact of epilepsy surgery on the structural connectome and its relation to outcome, NeuroImage: Clinical 18:202-214
2. Sinha, N., Dauwels, J., Wang, Y., Kaiser, M., Cash, S.S., Westover, M.B., Taylor, P.N., 2017, Predicting neurosurgical outcomes in focal epilepsy patients using computational modelling, Brain, 140 (2), 319-332 .
3. Hutchings, F., Han, C.E., Keller, S.S., Weber, B., Taylor, P.N.†, Kaiser, M.†, 2015. Predicting surgery targets in temporal lobe epilepsy through structural connectome based simulations, PloS Computational Biology 11 (12), e1004642
4. Sinha, N., Dauwels, J., Wang, Y., Cash, S.S., Taylor, P.N., 2014 An in silico approach for pre-surgical evaluation of an epileptic cortex, Proceedings IEEE EMBC 4884-4887

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Correctly predicted surgical outcomes in two epilepsy patients. Figure taken from Ref. 2.

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