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Epigenetics

1. Defects in the encoding of histone-modifying proteins (Chp 6 and 12 wk 1)

2. Epigenetics and (45) its role on human development. (chp 6)

3. Totipotent cells

4. Angelman syndrome? – loss of the maternal copy of UBE3A

Cellular Proliferation

1. 5-Azacytidine and the(44) treatment of cancer (Chap 6 & Chp 12- wk 1)

2. the role of inactive MLH1 in the development of some forms of inherited colon cancer.

3. Effects of ethanol on neural stem cells ability to differentiate into functional neurons (chap 13,wk 1) (Chap 2

4. Inflammation as an etiology for cancer-note conditions in which this may occur

Cancer

1. In terms of epigenetic modifications, the role of environmental stressors associated with development of cancer.

Defects in Mechanism of Defense

1. Hemolytic defects in the newborn

2. Understand the meaning of infectivity ( chap 10 )

3. Most effective treatment for HIV-

4. Defected cells of HIV

5. Signs of T-Lymphocyte deficiency

Pulmonary Alterations

1. Pulmonary function tests

2. Relationship of lung compliance and (46) residual volume

3. Shifts in the oxyhemoglobin dissociation- (chap 3, 17, 34)

4. CO2 transport in the blood ( chap 34)

5. Characteristics of alveoli-

6. Arterial perfusion pressure in the lung base and

7. alveolar gas pressure in the lung base

8. How do determine the partial pressure of oxygen given the percentage of oxygen in the air and

9. (23) the barometric pressure

10. Results of increased work of breathing Know terms: Chapter 34

11. Vital capacity (VC),

12. Total lung capacity

13. Functional capacity-

14. Residual volume (RV)

15. Functional residual capacity (FRC) –

Renal Alterations

1. Types of nephrons and (48) their functions (chap 37)

2. Overall renal physiology-

3. Substances that are actively secreted by the renal tubules (Chap39)

4. Activation of the renin-angiotensin system

5. Glomerular filtration rate- clearance

6. Mesangial cells-

7. Renal system anatomy

8. Why plasma proteins should be absent from the urine-

9. Effects of urinary tract obstruction- hydronephrosis and a

10. (39) decreased glomerular filtration rate

11. Effect of urinary retention

12. Epispadias

13. Glomerulonephritis- ( chap 38)

14. Nephrotic syndrome- ( chap 38)