# Links & Clues

22. This (wordle) reduces glucose absorption and improves ultrafiltration during peritoneal dialysis in rats.

21. This simple finding provides a lot of information about one's kidney function, but is often overlooked and the test is commonly underperformed (wordle)

20: This anticoagulant can cause hypokalemia through a purported diuretic effect (wordle)

19: Deficiency in this can result in a thrombotic microangiopathy (wordle)

18: High oral intake of this (wordle) helps alleviate hyperkalemia in type 1 pseudohypoaldosteronism

17: We need these to identify and assess the burden of kidney disease in specific populations.

16: In the absence of oral urea, this oral agent can be used to treat hyponatremia (wordle)

15: KDIGO, The American Diabetic Association (ADA), and NICE recommend SGLT2i and this as initial *dual* therapy for diabetic kidney disease (wordle)

14: This process is thought to be a marker of uremia (wordle answer)

13: This agent (wordle answer), recommended by KDOQI and along with a low protein diet, can reduce uremic symptoms

12: Surgeon who performed the first human-to-human cadaveric kidney transplantation (a Ukrainian physician) (last name) (wordle answer)

11: Fear of this condition (wordle answer) is unfounded when using balanced solutions. You will learn a lot more about this in the Brasil Scouting Report.

10: Arguably an important (perhaps most important) reason why SGLT2i aren't prescribed

9: This 'transporter' doesn't have the driving skills of Jason Statham and yet it has a stellar, non-anemic, rate of on-time arrival (wordle)

8: The SGLT2i arm in CANVAS had a higher rate of (wordle) (compared to placebo) but this finding was not observed in EMPA-REG, CREDENCE, DECLARE-TIMI, DAPA-HF, or DAPA-CKD

7: Magnitude of the problem: 850 (wordle) people suffer from kidney disease around the world

6: As of 2021, the SGLT2i that has shown one of the weakest improvements in renal outcomes (wordle)

5: Clearance x (wordle answer) = Excretion

4: Hartmann modified Ringer's solution with the addition of (wordle answer) in 1932

3: What A. de Schepper and Pyotr Ilyich Tchaikovsky have in common (wordle)

2: For every 1 kg/m-squared increase in BMI in patients with a baseline GFR >= 90, there is a (wordle answer) mL/min/1.73m-squared decline in eGFR (approximately) in 3 months post-nephrectomy. You'll learn more about this when you read the Argentina Scouting Report at the start of the Tournament

1: There are 4 types and sometimes they hurt (wordle)



# Answers

22. PHLORETIN bit.ly/j2022040474

21. PROTEINURIA

20: HEPARIN. https://twitter.com/AvrahamCooperMD/status/1444674306135441409

19: COBALAMIN. https://twitter.com/NKF_NephPros/status/1511685905567862793/photo/1

18: SODIUM.

17: REGISTRY. Learn more about registries with the Ghana Scouting Report.

16: WHEY. Learn more about oral urea, whey protein, and other treatment options for hyponatremia in the Players Forum.

15: METFORMIN. Join The Players Forum to learn from experts about this recommendation.

14: CARBAMYLATION. You can learn more about protein carbamylation in The Players Forum. Join today.

13: KETOANALOGUES

12: VORONOY. Help the people of Ukraine by visiting here.

11: HYPERKALEMIA

10: EXPERIENCE (lack of). Join the Players Forum to learn more about the barriers to SGLT2i by Cardiologists and Nephrologists)

9: FERROPORTIN.

8: AMPUTATION.

7: MILLION.

6: ERTUGLIFLOZIN. The VERTIS-CV trial.

5: CONCENTRATION. Dr. Sheldon Chen (of kinetic eGFR fame) breaks down clearance, excretion, and how to use the keGFR in ATN. Content available exclusively to Players Forum members (join for free to access all exclusive content)

4: LACTATE. You'll learn more about this with the Brasil Scouting Report at the start of The Tournament on 21 November.

3: NUTCRACKER: Renal nutcracker syndrome was first described by A. de Schepper in 1972. Tchiakovsky composed the score for the The Nutcracker ballet in 1892.

2: THREE.

1: STONE.

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