News
20-21st May 2023- MSBL actively participated in HistCON 2023 at Shoolini University, Himachal Pradesh
Dr. Shyam K Masakapalli provides insights on "Smart Biosystems and Smart Agriculture with focus on Himalayas". Mr Yogesh and Ms. Portia presented their research work through posters and received the Best Poster award (1st and 3rd position respectively). Congrats Mr. Yogesh and Ms. Portia
20-21st May 2023- MSBL actively participated in HistCON 2023 at Shoolini University, Himachal Pradesh
Dr. Shyam K Masakapalli provides insights on "Smart Biosystems and Smart Agriculture with focus on Himalayas". Mr Yogesh and Ms. Portia presented their research work through posters and received the Best Poster award (1st and 3rd position respectively). Congrats Mr. Yogesh and Ms. Portia
May 2023- Ms Jyotika, Dr Chandakant, and Dr Shyam get recognition from various national media groups for their discovery to identify microbial partners that can efficiently convert cellulosic waste into useful chemicals (News link). Congrats Ms Jyotika and Dr. Chandrakant for their innovative research work.
February 2023- Contribution to the exciting research study on "Synthetic microbial consortia bioprocessing integrated with pyrolysis for efficient conversion of cellulose to valuables" by Joshi et.al. This study shows a new path in bioprocessing towards the use of synthetic microbial consortia partners for the production of valuables from waste biomass like cellulose. Well done Dr. Chandrakant Joshi for your contribution. Bioresource Technology Reports https://doi.org/10.1016/j.biteb.2022.101316.
8th Feb 2023- Contributing to the research community, two new book chapters from MSBL addressing the hidden potential of phytochemicals and Bioactive compounds of the Himalayas. Congrats Ms. Shagun for her impactful work in this area.
5th Dec 2022-Proud moment for MSBL! 5 Scholars (3 PhDs and 2 MTechs )Dr. Chandrakant Joshi,Dr Poonam Jyoti, Dr.Maneesh Lingwan, Arpita Prasad and Vishali Dhiman received their Doctor of Philosophy and Post Graduation degree on 10 th Convocation IIT Mandi,2022
6th Oct 2022-Proud moment for MSBL! Mr. Chandrakant Joshi successfully defended and earned his Doctor of Philosophy (Congrats Dr. Chandrakant Joshi) Thesis Title - Synthetic microbial consortia for metabolically efficient bioprocessing of cellulose to platform chemicals
12-13th May 2022- MSBL actively participated in BioX Annual Conference 2022.
Dr. Shyam K Masakapalli provides insights on "Unravelling cell metabolism with multiple Isotopic tracers". Lab members presented their research work through posters and oral talks.
2nd May 2022- Contributed to the exciting research study on Transcription factors BBX11 and HY5 interdependently regulate the molecular and metabolic responses to UV-B with IISER Bhopal team. Well done Dr. Maneesh Lingwan for his contribution. Plant Physiology 2022 doi.org/10.1093/plphys/kiac195
13th April 2022- Contributed to the exciting research study on "Mutants lacking global regulators, fis and arcA, in Escherichia coli enhanced growth fitness under acetate metabolism by pathway reprogramming" with IIT Bombay team. This study deciphered the growth and flux distribution of E. coli transcription regulatory knockouts Δfis, ΔarcA and double deletion mutant, ΔarcAΔfis under acetate using 13C-metabolic flux analysis (MFA), which has not been investigated before. Well done Dr. Poonam Jyoti for her contribution. Applied Microbiology and Biotechnology doi.org/10.1007/s00253-022-11890-6
13th April 2022- Contributed to the exciting research study on "Mutants lacking global regulators, fis and arcA, in Escherichia coli enhanced growth fitness under acetate metabolism by pathway reprogramming" with IIT Bombay team. This study deciphered the growth and flux distribution of E. coli transcription regulatory knockouts Δfis, ΔarcA and double deletion mutant, ΔarcAΔfis under acetate using 13C-metabolic flux analysis (MFA), which has not been investigated before. Well done Dr. Poonam Jyoti for her contribution. Applied Microbiology and Biotechnology doi.org/10.1007/s00253-022-11890-6
28th Dec 2021- We profiled and investigated the phytochemicals of Rhododendron arboreum petals sourced from Himalayan flora, undertook in vitro studies, and found it a promising candidate against SARS-CoV-2. Well done Dr. Maneesh, Shagun, and ICGEB collaborators.doi.org/10.1080/07391102.2021.2021287
9th Dec 2021- Proud moment for MSBL! Ms. Poonam Jyoti successfully defended and earned her Doctor of Philosophy (Congrats Dr. Poonam Jyoti) Thesis Title -Metabolic Systems Biology of Ralstonia solanacearum by integrating Genomics and 13C Metabolic Flux Analysis
2nd Dec 2021- Excellent review on Organic waste conversion through anaerobic digestion is out at Metabolic Engineering. Congrats Chandrakant Joshi and Jyotika Thakur "Organic waste conversion through anaerobic digestion: A critical insight into the metabolic pathways and microbial interactions" doi.org/10.1016/j.ymben.2021.11.014
23rd Nov 2021- Proud moment for MSBL! Mr. Maneesh Lingwan successfully defended and earned his Doctor of Philosophy (Congrats Dr. Maneesh Lingwan). Thesis Title: Systems analysis of plant metabolism under UV-B radiation by integrating metabolomics and 13CO2 labeling June 18, 2021. We deciphered the PHB biosynthesis in Ralstonia solanacearum using 13C Mapping, Genome analysis and Bioprocessing. The metabolic insights can prove key to developing this bacterium as a future bioplastic factory. Congratulations Poonam and Nitin. ACS Chemical Biology 2021 see https://doi.org/10.1021/acschembio.1c00249
07 June 2021. Contributed to this exciting research study on Moss gametophore development with IISER Pune team. This work taught us how challenging it is to analyse Auxin and its derivatives. Well done Maneesh Lingwan for the LC-MS/MS workflow. Plant Physiology 2021 https://doi.org/10.1093/plphys/kiab261
25th Mar 2021 - Indo-UK Symposium on Fluxomics of Microbe and Plant Systems (FluxMAPS 2021) successfully organised with University of Oxford collaborators. https://iitmandi.ac.in/news/articles/files/FluxMAPS%202021.pdf. Congrats MSBL Team, this is a great contribution to the area of Fluxomics covering the Themes: Flux Balance Analysis in Plant Systems (https://www.youtube.com/watch?v=ymNYaNikNPU) and 13C Metabolic Flux Analysis in Plant and Microbial Systems (https://www.youtube.com/watch?v=kJ2oSaOYDHo).
12th Dec 2020 - Proud News - Three MSBL scholars - Dr Manu Shree (PhD), Mr Prem Chand and Mr Jayant Gudivada (MTechs) received their respective degrees in the convocation@IIT Mandi. Huge Congratulations all.
8th Dec 2020 - Poonam Jyoti presented her work to International audience at 2020 ASM Conference (8th-11th Dec 2020) on Rapid Applied Microbial Next-Generation Sequencing (NGS) and Bioinformatic Pipelines. Her poster is entitled "Integrating Genome analysis with 13C tracer studies provide deeper insights into the PHB metabolic pathways in Ralstonia solanacearum. Good going Poonam
20th Nov 2020 - MetSysBio Lab contributed to a collaborative study on 1-Carbon metabolism published in Journal of Biological Chemistry "Allosteric inhibition of MTHFR prevents futile SAM cycling and maintains nucleotide pools in one-carbon metabolism". DOI: 10.1074/jbc.RA120.015129. Congrats Jyotika Thakur
14th Oct 2020 - Shagun presented scientific poster in International conference Plant Specialized Metabolism and Metabolic Engineering (PSMME-2020), Organised by CIMAP Lucknow. Title - Comprehensive metabolome analysis of Acorus calamus essential oil and its associated phytochemical pathways. Well done Shagun.
13th Oct 2020 - MetSysBio Lab contributed to a collaborative work "A Nuclear Magnetic Resonance (NMR) Platform for Real-Time Metabolic Monitoring of Bioprocesses" published in Molecules (MDPI). DOI: 10.3390/molecules25204675. Congrats Chandrakant Joshi
6th Sept 2020 - G2KO Tool out from MetSysBio Lab "Efficient System Wide Metabolic Pathway Comparisons in Multiple Microbes Using Genome to KEGG Orthology (G2KO) Pipeline Tool" Published in Interdisciplinary Sciences: Computational Life Sciences DOI: 10.1007/s12539-020-00375-7. Congrats Chandrakant Joshi
6th Sept 2020 - G2KO Tool out from MetSysBio Lab "Efficient System Wide Metabolic Pathway Comparisons in Multiple Microbes Using Genome to KEGG Orthology (G2KO) Pipeline Tool" Published in Interdisciplinary Sciences: Computational Life Sciences DOI: 10.1007/s12539-020-00375-7. Congrats Chandrakant Joshi
1st April 2020 - Excellent review on Light/UV-B on Plants is out in Journal of Integrative Plant Biology. Congrats Maneesh Lingwan "Light signaling and UV-B-mediated plant growth regulation" DOI: 10.1111/jipb.12932
10th March 2020 - Awesome news. Ralstonia metabolism paper with novel insights out in mSystems - Congrats Poonam Jyoti for leading this original study - The Entner-doudoroff and nonoxidative pentose phosphate pathways bypass glycolysis and the oxidative pentose phosphate pathway in Ralstonia solanacearum. DOI: 10.1128/mSystems.00091-20
6th March 2020 - Proud moment for MSBL! Ms Manu Shree successfully defended and earned her Doctor of Philosophy (Congrats Dr Manu Shree). Thesis Title - Mapping central carbon metabolism of Xanthomonas oryzae and Xanthomonas campestris by integrating Metabolic Systems Biology approaches