Shyam K. Masakapalli's
Metabolomics, Fluxomics and Chemical Biology for Bioprocessing, Smart Agriculture and Health Applications
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Explore Fluxomics and Metabolomics to decode cellular metabolism with Our Lab
Explore Fluxomics and Metabolomics to decode cellular metabolism with Our Lab
Welcome to MSBL
Welcome to MSBL
What's New..?
What's New..?
Our team developed an efficient way to use domestic wastewater, which has very complex carbon sources. This study demonstrates how the combined methods of bioflocculation, alkali pretreatment, and AD can transform household wastewater into biogas and reusable organic molecules. Well done Ms Jyotika Thakur and team
Our team developed synthetic microbial consortia produced platform chemicals from cellulose. Remaining solid biomass at the end of bioprocess was pyrolyzed to produce carbon. Bioprocess integrated with pyrolysis is promising for cellulose to valuables. Well done Dr. Chandrakant Joshi and team
We contributed in deciphering the growth and flux distribution of E. coli transcription regulatory knockouts Δfis, ΔarcA and double deletion mutant, ΔarcAΔfis under acetate using 13C-metabolic flux analysis (MFA), which has not been investigated before. Well done Dr. Poonam and Dr. Shikha (IIT Bombay)
Our team developed an efficient way to use domestic wastewater, which has very complex carbon sources. This study demonstrates how the combined methods of bioflocculation, alkali pretreatment, and AD can transform household wastewater into biogas and reusable organic molecules. Well done Ms Jyotika Thakur and team
Our team developed synthetic microbial consortia produced platform chemicals from cellulose. Remaining solid biomass at the end of bioprocess was pyrolyzed to produce carbon. Bioprocess integrated with pyrolysis is promising for cellulose to valuables. Well done Dr. Chandrakant Joshi and team
We contributed in deciphering the growth and flux distribution of E. coli transcription regulatory knockouts Δfis, ΔarcA and double deletion mutant, ΔarcAΔfis under acetate using 13C-metabolic flux analysis (MFA), which has not been investigated before. Well done Dr. Poonam and Dr. Shikha (IIT Bombay)
January 2025 - Proud moment for MSBL! Ms. Shagun successfully defended and earned her Doctor of Philosophy (Congrats Dr. Shagun) Thesis Title - Deciphering the therapeutic potential of phytochemicals through metabolomics, database creation, molecular screening and 13C Metabolic Flux Analysis
December 2024 - Proud moment for MSBL! Dr. Shyam Kumar Masakapalli was being promoted as Professor at the School of Biosciences and Biengineering of IIT Mandi. Congratulation, Prof. Shyam.
November 2024 - Contribution to waste water management research on "Integration of bioflocculation with anaerobic digestion guided by physicochemical profiling enhances valorization potential of domestic wastewater" Congrats, Jyotika, for publishing her work. Bioresource Technology DOI: https://doi.org/10.1016/j.biortech.2024.131732
Sept 2024 - Proud moment for MSBL! Mr. Yogesh Pant successfully defended and earned his Doctor of Philosophy (Congrats Dr. Yogesh Pant) Thesis Title - Comprehensive profiling of biochemical, metabolite, and fatty acid transitions in Mustard Seeds and Seedlings during germination and exposure to different light wavelengths
Aug 2024 - Contribution to Smart agriculture and farming research on "Mapping of on-field soil nutrient variabilities as a guiding force for smart farming: a case study from FarmerZone sentinel-1 from three potato agroecological zones of India." Congrats, Portia for publishing her work. Environ Monit Assess DOI: https://doi.org/10.1007/s10661-024-12945-z.
July 2024 - Contribution to Human-computer Interaction study on "User Participation through WhatsApp – Mobile Instant Messaging as a Medium for Distributed Co-design" by Portia. Well done Portia for your contribution. DIS '24: Proceedings of the 2024 ACM Designing Interactive Systems Conference DOI: https://doi.org/10.1145/3643834.3661625.
May 2024 - Contribution to phytochemistry research study on "Mass spectrometry and Nuclear magnetic resonance spectroscopy profiles of red and pink Rhododendron flower petals establish them as rich sources of bioactive secondary metabolites." by Ms Shagun. Congrats Shagun for her research publication.
Sep Sci plus. DOI: https://doi.org/10.1002/sscp.202400007
November 2023 - Contribution to lipidomics research study on "Metabolic, Biochemical, Mineral and Fatty acid profiles of edible Brassicaceae microgreens establish them as promising functional food. Food Chemistry Advances" by Yogesh. Congrats Yogesh for your work. Food Chemistry Advances DOI: 10.1016/j.focha.2023.100461
August 2023 - Contribution to the exciting research study on "Genome-scale metabolic model led engineering of Nothapodytes nimmoniana plant cells for high camptothecin production" by Shagun. Well done Shagun for your contribution. Frontiers in Plant Science https://www.frontiersin.org/articles/10.3389/fpls.2023.1207218
February 2023- Contribution to the exciting research study on "Synthetic microbial consortia bioprocessing integrated with pyrolysis for efficient conversion of cellulose to valuables" by Dr. Chandrakant Joshi. This study shows a new path in bioprocessing towards the use of synthetic microbial consortia partners for the production of valuables from waste biomass like cellulose. Well done Dr. Chandrakant Joshi for your contribution. Bioresource Technology Reports https://doi.org/10.1016/j.biteb.2022.101316.
Feb 2023- Contributing to the research community, two new book chapters from MSBL addressing the hidden potential of phytochemicals and Bioactive compounds of the Himalayas. Congrats Ms. Shagun for her impactful work in this area.
Oct 2022- Proud moment for MSBL! Mr. Chandrakant Joshi successfully defended and earned his Doctor of Philosophy (Congrats Dr. Chandrakant Joshi) Thesis Title -Synthetic microbial consortia for metabolically efficient bioprocessing of cellulose to platform chemicals
May 2022- Contributed to the exciting research study on Transcription factors BBX11 and HY5 interdependently regulate the molecular and metabolic responses to UV-B with IISER Bhopal team. Well done Dr. Maneesh Lingwan for his contribution. Plant Physiology 2022 doi.org/10.1093/plphys/kiac195
April 2022 - Contributed to the exciting research study on "Mutants lacking global regulators, fis and arcA, in Escherichia coli enhanced growth fitness under acetate metabolism by pathway reprogramming" with IIT Bombay team. This study deciphered the growth and flux distribution of E. coli transcription regulatory knockouts Δfis, ΔarcA, and double deletion mutant, ΔarcAΔfis under acetate using 13C-metabolic flux analysis (MFA), which has not been investigated before. Well done Dr. Poonam Jyoti for her contribution. Applied Microbiology and Biotechnology doi.org/10.1007/s00253-022-11890-6
December 2021: Our research work on investigating the phytochemicals of Rhododendron arboreum petals and exploring it as a promising candidate against SARS-CoV-2 is out in the Journal of Biomolecular Structure and Dynamic. Congrats Dr. Maneesh and Shagun "Phytochemical rich Himalayan Rhododendron arboreum petals inhibit SARS-CoV-2 infection in vitro" https://doi.org/10.1080/07391102.2021.2021287
December 2021- Proud moment for MSBL! Ms. Poonam Jyoti successfully defended and earned her Doctor of Philosophy (Congrats Dr. Poonam Jyoti) Thesis Title -Metabolic Systems Biology of Ralstonia solanacearum by integrating Genomics and 13C Metabolic Flux Analysis
December 2021- Excellent review on Organic waste conversion through anaerobic digestion is out at Metabolic Engineering. Congrats Chandrakant Joshi and Jyotika Thakur "Organic waste conversion through anaerobic digestion: A critical insight into the metabolic pathways and microbial interactions" doi.org/10.1016/j.ymben.2021.11.014
November 2021- Proud moment for MSBL! Mr. Maneesh Lingwan successfully defended and earned his Doctor of Philosophy (Congrats Dr. Maneesh Lingwan). Thesis Title: Systems analysis of plant metabolism under UV-B radiation by integrating metabolomics and 13CO2 labeling
Research/Job opportunities
Currently, there are no openings at MetSysBio Lab. Intrigued candidates can contact Dr Shyam for available positions
Reach Us!
Reach Us!
Metabolic Systems Biology Lab
School of Biosciences and Bioengineering,
A-6 Building, South Campus,
Indian Institute of Technology, Mandi
Mandi, Himachal Pradesh, India (175075)
Office: +91-1905-267151
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