Explore Fluxomics and Metabolomics to decode cellular metabolism with Our Lab
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What's New..?
Our team developed synthetic microbial consortia produced platform chemicals from cellulose. Remaining solid biomass at the end of bioprocess was pyrolyzed to produce carbon. Bioprocess integrated with pyrolysis is promising for cellulose to valuables. Well done Dr. Chandrakant Joshi and team
We contributed in deciphering the growth and flux distribution of E. coli transcription regulatory knockouts Δfis, ΔarcA and double deletion mutant, ΔarcAΔfis under acetate using 13C-metabolic flux analysis (MFA), which has not been investigated before. Well done Dr. Poonam and Dr. Shikha (IIT Bombay)
Review on Organic waste conversion through anaerobic Exploring the metabolic bottlenecks of the microbial communities adopting latest advances of profiling and 13C tracer-based analysis using state of the art analytical platforms (GC, GC-MS, LC-MS, NMR). Well done Chandrakant and Jyotika
Metabolic Engineering 2022 https://www.sciencedirect.com/science/journal/10967176
Published: Jan 02, 2022
November 2023 - Contribution to research study on "Metabolic, Biochemical, Mineral and Fatty acid profiles of edible Brassicaceae microgreens establish them as promising functional food. Food Chemistry Advances" by Yogesh. Congrats Yogesh for your work. Food Chemistry Advances DOI: 10.1016/j.focha.2023.100461
August 2023 - Contribution to the exciting research study on "Genome-scale metabolic model led engineering of Nothapodytes nimmoniana plant cells for high camptothecin production" by Shagun. Well done Shagun for your contribution. Frontiers in Plant Science https://www.frontiersin.org/articles/10.3389/fpls.2023.1207218
February 2023- Contribution to the exciting research study on "Synthetic microbial consortia bioprocessing integrated with pyrolysis for efficient conversion of cellulose to valuables" by Dr. Chandrakant Joshi. This study shows a new path in bioprocessing towards the use of synthetic microbial consortia partners for the production of valuables from waste biomass like cellulose. Well done Dr. Chandrakant Joshi for your contribution. Bioresource Technology Reports https://doi.org/10.1016/j.biteb.2022.101316.
Feb 2023- Contributing to the research community, two new book chapters from MSBL addressing the hidden potential of phytochemicals and Bioactive compounds of the Himalayas. Congrats Ms. Shagun for her impactful work in this area.
Oct 2022- Proud moment for MSBL! Mr. Chandrakant Joshi successfully defended and earned his Doctor of Philosophy (Congrats Dr. Chandrakant Joshi) Thesis Title -Synthetic microbial consortia for metabolically efficient bioprocessing of cellulose to platform chemicals
May 2022- Contributed to the exciting research study on Transcription factors BBX11 and HY5 interdependently regulate the molecular and metabolic responses to UV-B with IISER Bhopal team. Well done Dr. Maneesh Lingwan for his contribution. Plant Physiology 2022 doi.org/10.1093/plphys/kiac195
April 2022 - Contributed to the exciting research study on "Mutants lacking global regulators, fis and arcA, in Escherichia coli enhanced growth fitness under acetate metabolism by pathway reprogramming" with IIT Bombay team. This study deciphered the growth and flux distribution of E. coli transcription regulatory knockouts Δfis, ΔarcA, and double deletion mutant, ΔarcAΔfis under acetate using 13C-metabolic flux analysis (MFA), which has not been investigated before. Well done Dr. Poonam Jyoti for her contribution. Applied Microbiology and Biotechnology doi.org/10.1007/s00253-022-11890-6
December 2021: Our research work on investigating the phytochemicals of Rhododendron arboreum petals and exploring it as a promising candidate against SARS-CoV-2 is out in the Journal of Biomolecular Structure and Dynamic. Congrats Dr. Maneesh and Shagun "Phytochemical rich Himalayan Rhododendron arboreum petals inhibit SARS-CoV-2 infection in vitro" https://doi.org/10.1080/07391102.2021.2021287
December 2021- Proud moment for MSBL! Ms. Poonam Jyoti successfully defended and earned her Doctor of Philosophy (Congrats Dr. Poonam Jyoti) Thesis Title -Metabolic Systems Biology of Ralstonia solanacearum by integrating Genomics and 13C Metabolic Flux Analysis
December 2021- Excellent review on Organic waste conversion through anaerobic digestion is out at Metabolic Engineering. Congrats Chandrakant Joshi and Jyotika Thakur "Organic waste conversion through anaerobic digestion: A critical insight into the metabolic pathways and microbial interactions" doi.org/10.1016/j.ymben.2021.11.014
November 2021- Proud moment for MSBL! Mr. Maneesh Lingwan successfully defended and earned his Doctor of Philosophy (Congrats Dr. Maneesh Lingwan). Thesis Title: Systems analysis of plant metabolism under UV-B radiation by integrating metabolomics and 13CO2 labeling
Research/Job opportunities
Currently, there are no openings at MetSysBio Lab. Intrigued candidates can contact Dr Shyam for available positions
Reach Us!
Metabolic Systems Biology Lab
School of Biosciences and Bioengineering,
A-6 Building, South Campus,
Indian Institute of Technology, Mandi
Mandi, Himachal Pradesh, India (175075)
Office: +91-1905-267151