These were the four primary antagonists for the story: Mayhem, Devilinya, Madame Witch, and Norto.
When the story originated along the lines gathering all of the characters together for deadly martial arts tournament in the vein of Street Fighter and/or Mortal Kombat, Norto was created as the final boss of sorts.
Devilinya's gauntlet was inspired by both Marvel Comics' Infinity Gauntlet (commonly wielded by Thanos) and Mozenrath's gauntlet from Aladdin: The Animated Series. You can even look closely at it and see the "Ultra Gems" housed inside of it. It was a device made to enhance her fallen deity powers to new heights.
Madame Witch would be the team's former friend, Peace (who was a demi-goddess), succumbing to evil as she sought out more power. Dark magic corrupted her until she took this form. If I ever scan the comic that I completely drew out for a final project in AP Art class for senior year of high school, you will see firsthand that she was the primary antagonist for that comic and the majority of the non-digital chapters of this story.
Originally a mad scientist aiding the Cybers (mutants who had their powers further enhanced by alien cybernetic organisms similar to Star Trek's Borg species), Dr. Power gave his mind and body to the Cybers to become their powerful leader known as Mayhem. Mayhem fell into the realm of Apocalypse where I felt there were times where I made him too powerful for his own good while others he was merely a scapegoat that easily defeated.