The objective of the 3rd edition of this advanced course is to introduce bioscience researchers to contemporary bioanalytical techniques and methods and combinations thereof for analyses and characterization, with a strong focus on preparation and scoring of samples for synchrotron and FEL radiation-based structure analysis. A a well-characterized sample of the biomolecule of interest is the key to obtain high-quality and trustworthy data with whichever bioanalytical technique applied. A multidisciplinary blend of lectures and practical exercises will allow the participants to interact closely with expert tutors to maximize training outcome.

Organizers: Jeroen Mesters, Christian Betzel, Deadline for applications: YTFs, April 21, 2022; Other, May 7, 2022

Session 1: ESRF Overview

Session 2: Biomedical imaging & Cultural heritage

Session 3: Life Sciences

Session 4: Energy – Catalysis – Environment

Sessions 5 & 6: Nanoscale matter & Quantum Materials | Industrial Research & Activities 

Registration is now open and available via the link below.

Abstract The extremely brilliant synchrotron source (EBS) of the European Synchrotron (ESRF) delivers X-rays for fast and multiresolution tomography. This 3D non-destructive technique images the inside of bulk samples. In this webinar, we will introduce the multiscale capabilities for tomography at the ESRF.

Our tomography X-ray beamlines, all accessible by industry, cover a wide range from 10 nanometers to several microns in resolution. The different X-ray energies available coupled with different types of contrasts, using the special properties of synchrotron X-rays, allow a huge range of samples from soft matter to metallic alloys to be scanned, offering applications in every industry sector from energy and electronics, aerospace to food biomedical and health and engineering. The ultra-fast acquisition opens temporal resolution and enables 4D studies using specific sample environments for in situ experiments. 

These state-of-the-art instruments can be booked for industrial purposes and ESRF dedicated staff are available to provide you with all required information, scientific and technical support, including a mail-in service.

Topic A trip into the heart of industry materials with multiscale X-ray tomography

Date 15 JUNE 2021 from 11:00 to 11:30 AM CEST

Registration link https://esrf.zoom.us/webinar/register/WN_HZJ9eQ3UT4qy8EPpSqsSVQ

The entire event will be held in English. We are looking forward to your participation!. Your ESRF Business Development Team. 

Thomas Schneider, Dmitri Svergun and Matthias Wilmanns

https://youtu.be/Ma8lRp5olAI

The meeting provides a review of state of the art profile fitting analyses using TOPAS, hosting a program of invited speakers. The major component is to demonstrate TOPAS's outstanding modeling methods and related applications in X-ray and neutron diffraction. Participation is open for anyone, TOPAS users and non-users, interested in learning more about the TOPAS capabilities and applications. Participants are encouraged to submit discussion topics in advance to the organizers. The final schedule will take issues of general interest into account. Presentations and example data used will be distributed to the participants as made available by the speakers.

The 15th TOPAS Users' Meeting preceeds the 17th European Powder Diffraction Conference (EPDIC17) held in Šibenik, Croatia, same location:

-              https://www.epdic17.org

-              https://www.epdic17.org/topas-users-meeting

A downloadable agenda (PDF format) can be found here:

-              https://www.bruker.com/events/users-meetings/x-ray-diffraction-and-elemental-analysis/topas-users-meeting.html

Fees and Registration:

-              https://www.epdic17.org/registration

Organizers:

-              Arnt Kern, Bruker AXS, Germany (Arnt.Kern@bruker.com)

-              Dragica Prill, Frankfurt University, Germany

 

The Polikanov Laboratory at the University of Illinois at Chicago (IL, USA) is looking for a talented, skillful, and highly motivated researcher to fill the available NIH-funded Post-Doctoral Scholar position to study the structure and function of the bacterial ribosome.

The research in the Polikanov Laboratory is focused on understanding the basic principles of protein synthesis in bacteria, the modes of action of ribosome-targeting antibiotics, and the mechanisms of drug resistance at a structural level. More information about Dr. Polikanov research can be obtained from the most recent publications (https://www.ncbi.nlm.nih.gov/sites/myncbi/yury.polikanov.1/bibliography/50395623/public/?sort=date&direction=descending) or found on the web-page (https://bios.uic.edu/bios/people/faculty/yury-polikanov). The successful candidate will be involved in the determination of high-resolution structures of ribosome functional complexes with various protein translation factors, tRNAs, and antibiotics using macromolecular X-ray crystallography and potentially cryo-EM techniques.

Basic qualifications: 

The successful candidate is also expected to:

Review of applications will begin immediately and will continue until the position is filled. Interested candidates should send their CV, cover letter, and contact information for three references directly to Dr. Yury Polikanov at yuryp@uic.edu. In the cover letter, the applicant should describe how his/her previous research accomplishments and scientific interests fit with the scope of the research in the Polikanov research group.

Web-Page: http://bios.uic.edu/bios/people/faculty/yury-polikanov


This is the (maybe) last reminder that registrations for the 55th Course of the International School of Crystallography (Structural Drug Design) to be held in the beautiful town of Erice (Italy) May 29 – June 6, 2020 (www.crystalerice.org) will close on Saturday November 30, 2019

The International School of Crystallography has been active since 1974, and over the years has brought together a remarkable number of scientists from many different countries.  Applicants may be able to apply for financial support, and we will try to provide as many young students and researchers as possible with financial help.

The purpose of the 55th course is to provide the students with

a) An overview of the current structural and biophysical techniques used in the field;

b) The use of informatics tools in drug discovery;

c) The evolving role of chemistry in drug design and biology understanding; and

d)  An introductions to biologics and their applications.  

Speakers committed to participate to the school include Tom Blundell (Cambridge UK), Charles Lesburg (MSD, Boston, USA), James Fraser (UCSF, S. Francisco, CA, USA), Lucia Banci (Florence University, Italy), Ben Davis (Vernalis, Cambdrige, UK), Sandra Jacob (Novartis, CH), Georgia McGaughey (Vertex, USA), and Eddy Arnold (Rutgers, NJ, USA).

Please see the enclosed poster and visit the school website (www.crystalerice.org) for further information.

We are looking forward to welcoming you in Erice

Giovanna Scapin

Sr. principal scientist

Computational and Structural Chemistry

Merck & Co., Inc.

2000 Galloping hill road

Kenilworth, NJ 07033


https://drive.google.com/open?id=1CK-OoUAiiWQerCRYmyF9RsVQHyN5qhUb

https://drive.google.com/open?id=1uQ5gZ04o2GRmzUqNFbN300QKZvM8MZfo


The information about the School content and format, practical information (deadlines and fees) and the application link are available at:

https://community.dur.ac.uk/john.evans//webpages/pdrr_school.htm

As in previous years, we will offer a combination of lectures covering the theoretical aspects of powder diffraction and Rietveld refinement, classroom-based “by-hand” problem sessions/tutorials and extensive hands-on practical sessions using a variety of modern software packages.

Topics to be covered will include:

Lectures will be given by Prof. John Evans, Prof. Ivana Evans, Dr. Jeremy Cockcroft and Prof. Andy Fitch.

  

 The International School of Crystallography has been active since 1974, and over the years has brought together a remarkable number of scientists from many different countries.  The purpose of the 55th course is to provide the students with

a) An overview of the current structural and biophysical techniques used in the field;

b) The use of informatics tools in drug discovery;

c) The evolving role of chemistry in drug design and biology understanding; and

d)  An introductions to biologics and their applications.  

Speakers committed to participate to the school include Tom Blundell (Cambridge UK), Charles Lesburg (MSD, Boston, USA), James Frasier (UCSF, S. Francisco, CA, USA), Lucia Banci (Florence University, Italy), Ben Davis (Vernalis, Cambdrige, UK), Sandra Jacob (Novartis, CH), Georgia McGaughey (Vertex, USA), and Eddy Arnold (Rutgers, NJ, USA).

 Please see the enclosed poster and visit the school website (www.crystalerice.org) for further information.

Giovanna Scapin

Sr. principal scientist

Computational and Structural Chemistry

Merck & Co., Inc.

2000 Galloping hill road

Kenilworth, NJ 07033

 

Location: Nexus, Leeds, UK

Date: 25 November 2019

Deadline for registration: 31 October 2019 by booking online

Contact: stephanie@instruct-eric.eu

Join us for a one-day event, exploring the advances in technology and infrastructure that are revolutionising the way in which we interpret molecular and cellular functions, and find out how integrative approaches are connecting atomic-level structure with functionality at the cellular level.

The launch event will showcase the electron microscopy, NMR and mass spectrometry technologies and expertise of the Astbury Centre, and provides a chance to discover the funded research opportunities that are available through Instruct - including machine access, training, internships and R&D pilot project awards. As well as talks from experts in structural biology, there will be an opportunity to tour the facilities on offer through Instruct, and to ask your scientific questions directly to the specialists. For more information and to register for the event, click here.

The Instruct Practical Course "Hydrodynamic and thermodynamic analysis of biological macromolecules and their interactions: multi-method approaches and global data analyses", co-sponsored by FEBS and Arbre-Mobieu.

Location: Instruct-FR2 Centre, Grenoble, France

Date: 26 - 31 January 2020

Deadline for applications: 30 October 2019 by booking online

Contact: ibs.evt.hythabio@ibs.fr

This course will provide theoretical, practical, and data analysis training in modern biophysical methods used to monitor and quantify molecular interactions - mainly analytical ultracentrifugation (AUC), isothermal titration calorimetry (ITC), surface plasmon resonance (SPR), and biolayer interferometry (BLI). The course will cover the biophysical theory, sample preparation, instrument demonstration and hands-on data analysis using computational tools. For more information and to register for the training course, click here.

The course is part of the 2019/20 Instruct training programme, which is a series of Instruct-sponsored workshops covering a wide range of structural biology techniques. For information about other similar courses, click here.


Last week, there was a broadcast of a discussion of Dorothy Hodgkin's life and work on BBC Radio 4. For those of you outside the UK or who missed it, it can be listened to or downloaded here: <https://www.bbc.co.uk/programmes/m0008wkk>. As far as I can tell, there are no geographical restrictions, and it can be accessed from anywhere.

One of the panellists was Prof. Judith Howard, whom some of you know.


INNOVATIVE NANOMEDICINES FOR TARGETED DRUG DELIVERY AND PERSONALIZED APPROACHES

Patras, July 8-10, 2019 

University of Patras & FORTH/ICE-HT

Sessions:

-Development of Nanomedicines and Targeted Nanomedicines 

-New delivery/targeting approaches for urgent medical needs

-Advanced Methodologies for Characterization of Materials and Nanomaterials (Applications in Nanomedicines)

-Nanotechnologies in Biosensors, Diagnostics and Imaging

Invited Speakers (in alphabetical order):

K. Andrieux (Paris, FR); E. Chiesa (Pavia, IT); T. Christopoulos (Patras, GR); D. Fixler (Bar Ilan, IS); A. Gravanis (Herakleio, GR); G. Gregoriadis (London, UK); P. Luciani (Bern, CH); P. Macheras (Athens, GR); M. Morpurgo (Padova, IT); S. Rahimipour (Bar Ilan, IS); C. Reppas (Athens, GR); M. Vertzoni (Athens, GR); and others (pending) 

Organizers: S.G. Antimisiaris, P. Klepetsanis

For more information and registration link visit nanomed2019.upatras.gr

http://xxxiv-ssm.upatras.gr/?utm_source=newsletter&utm_medium=email&utm_campaign=Reminder-+31.05.2019




Dear all,

we are happy to announce the upcoming EMBO practical course on "Practical Integrative Structural Biology" to be held from Nov 3-9, 2019 at EMBL and the Centre for Structural Systems Biology (CSSB), both on DESY campus in Hamburg, Germany. 

Participants will learn how information from different structural biology techniques (MX, EM, SAXS and NMR) can be combined with computational modelling techniques to address the three-dimensional structure of challenging biomolecular complexes. Participants will collect data at on-site structural biology facilities, analyse these data and subsequently build integrative models using major software packages developed by the invited speakers. 

We have put together a diverse and in-depth program of talks and practicals covering all of the above topics, each of them taught and supervised by outstanding experts and software developers in their respective fields. 

Interested? Then please apply via the course website: http://meetings.embo.org/event/19-integrative-structural-biology.

On behalf of the organisers,

Jan Kosinski  (organiser)

Matthias Wilmanns (co-organiser)

Arjen Jakobi  (co-organiser)


We would like to draw your attention to the International Student Summer School which will be organised this Summer by the ILL and the ESRF.

This is an excellent opportunity for any student interested in discovering neutron and X-ray techniques and the research carried out at our institutes. 

A pdf file of the announcement poster (below) can be downloaded from the web site below.

https://workshops.ill.fr/event/200/

The organisation committee

P. Bruno, P. Steffens, L. Tellier, F. Lugiez

Summer School Web-site


https://www.helmholtz-berlin.de/user/beamtime/proposals/index_en.html


As usual, all proposals will be handled with the new version of GATE,

GATE2.0, https://www.helmholtz-berlin.de/pubbin/hzbgate


Hereby we would like to invite the submission of new proposals for

MX-beamtime at the HZB-MX beamlines for the next beam time period

(09/2019-02/2020).

In order to apply for beamtime, please register at the HZB on-line

access tool "GATE" (https://www.helmholtz-berlin.de/pubbin/hzbgate)

and submit a new beam time application proposal.

With the new GATE version, the proposal categories have been improved. 

We now expect from each research group only ONE proposal, which can 

contain up to 20 individual projects.

HZB provides MX-beamtime at the three MX-beamlines BL14.1, BL14.2

and BL14.3. The three beamlines are equipped with state-of-the-art

instrumentation and are currently the most productive MX-stations in

Germany with over 300 PDB depositions annually. Beamtime is granted

based on the reviewed proposals and on reports from previous research

activities. Please make sure to include them if available.

Experimental setup:

BL14.1:

- Photon energy range: 5.5-16 keV (wavelength: 0.77502.25 A)

- Photon flux: 1.8x10¹¹ Phot/sec x 100 mA at sample position

  (0.1-1 sec exposure time per frame)

- PILATUS 6M detector, 141 mm-680 mm max. distance from the sample

- Microdiffractometer (MD2) with Mini-kappa goniometer

- Automatic sample changer (CATS), 90 sample storage capacity

  (SPINE-Pin & EMBL sample magazine compatibility)

- User defined beam shaping from 50 µm-100 µm diameter possible

- In situ crystal-screening using 96-well plates

- 32-core XEON-CPU server, with 10GB uplink to Pilatus 6M

- Data collection control via MXCuBE2

- Common MX-software installed including EDNA, XDS, iMOSFLM, CCP4,

  Phenix, SHELXC-D-E, etc.

- Automated data processing using XDSAPP

- Remotely controlled cryo-shutter for crystal annealing

- AMPTEK-XRF detector and XFEPLOT software available

We are also offering the hard- and software environment for

carrying out UV-RIP experiments at BL14.1. For further information, 

please visit:

https://www.helmholtz-berlin.de/forschung/oe/np/gmx/ancillary-facilities/uvrip_en.html

BL14.2:

- Photon energy range: 5.5-16 keV (wavelength: 0.77502.25 A)

- Photon flux: 1.6x10¹¹ Phot/sec x 100 mA at sample position

  (0.05-1 sec exposure time per frame)

- PILATUS 3S-2M detector with 1000 µm Si sensor thickness,

  85 mm - 800 mm distance from the sample (a special mode with 

  55 mm distance is also available upon request)

- Nanodiffractometer with fast air-bearing axis and on-axis sample 

  microscope

- User defined beam shaping from 30 µm-150 µm diameter possible

- Data collection control via MXCuBE2

- G-ROB sample changer for SPINE and UNIPUCK support

- 60-core XEON-CPU server, with fibre channel SAN up-link data

  processing environment

- Common MX-software installed including EDNA, XDS, iMOSFLM, CCP4, 

  Phenix, SHELXC-D-E, etc.

- Automated data processing using XDSAPP

- AMPTEK-XRF detector and XFEPLOT software available

- UV-Microsprectrophotometer offline setup available

If you need atomic resolution or better, BL14.2 is the beamline

of choice for you.


BL14.3:

- Fixed photon energy: 13.8 keV (wavelength: 0.89 A)

- Photon flux: 1.6x10exp10 Phot/sec x 100mA at sample position

  (3-20 sec exposure time per frame)

- Rayonix MX-225 X-ray detector, 54 mm-450 mm distance from the

  sample

- MD2S microdiffractometer with mini-kappa goniometer

- In situ crystal-screening using 96-well plates

- RT data collection

- 60-core XEON-CPU server, with fibre channel SAN up-link data

  processing environment

- Data collection control via MXCuBE2

- Common MX software installed including EDNA, XDS, iMOSFLM, CCP4, 

  Phenix, SHELXC-D-E, etc.

- Automated data processing using XDSAPP

- Remotely controlled cryo-shutter for crystal annealing

- REX rapid nozzle exchanger

- HC-Lab dehydration device installed (please specify HC-Lab-beamtime

  in your proposal if needed)

- AMPTEK-XRF detector and XFEPLOT software available

Other facilities:

- Ultra high performance stereo microscope Leica M205A, 20-255x zoom,

  8 Mpixel CCD-camera

- Pressure chamber for noble gas derivatization (Xe, Kr available

  upon request)

S1-biolab facilities (separate registration required):

- Protein production and purification (AEKTA)

- nL 96-well crystallization plate formulation and storage at

  5°C and 20°C

- Biophysical characterization with real time PCR (thermofluor assay)

- Contactless compound pipetting using ATS

The HZB-MX group is also providing expert assistance as well as

access to a library of fragments for carrying out crystallographic

fragment-screening experiments. For more information please see 

https://www.helmholtz-berlin.de/forschung/oe/np/gmx/fragment-screening/index_en.html

or contact msweiss@helmholtz-berlin.de.

Please visit our web page www.helmholtz-berlin.de/bessy-mx to obtain

updated information about our experimental setup and other

requirements.

Dr. Manfred S. Weiss

Macromolecular Crystallography

Helmholtz-Zentrum Berlin

Albert-Einstein-Str. 15

D-12489 Berlin

Germany

The fourth Instruct Biennial Structural Biology Conference will take place in Alcala de Henares, Madrid, Spain from the 22-24th of May 2019.

Confirmed speakers includes:

Julia Mahamid European Molecular Biology Laboratory

Sjors Scheres MRC Laboratory of Molecular Biology

Poul Nissen Aarhus University

Eva Pereiro ALBA Synchrotron

Teresa Carlomagno Leibniz University Hannover

Ada Yonath Weizmann Institute

Andy Dore Heptares

Hashim M Al-Hashimi Duke University

Andrej Sali University of California

Dave Stuart Instruct-ERIC, University of Oxford

Dorit Hanein Institut Pasteur

Brent Nannenga Arizona State University

Patrick England Institut Pasteur

Ilaria Ferlenghi GSK Vaccines

Alex De Marco Monash University

Upcoming submission opportunities/deadlines include:

Abstract submission: March 1

Young scientists interested in gaining a broader understanding of structural biology and its community are especially encouraged to attend.

We encourage scientists from all stages of their career to submit abstracts, from whom four will be chosen to present their work at the meeting.

Fellowships closing: March 1

Ten fellowships are available for students and four other fellowships offered for Women in Science. This covers registration travel costs and shared accommodation. For more information click here https://instruct-eric.eu/biennial2019#fellowships

Even if you are not sure that you will receive a fellowship, you are warmly encouraged to register for the meeting. Coming from an Instruct country, your registration is only €65, which is a 85% discount on the full registration fees of €450 for non-members.

Please note my new email address

Dr Claudia Alen Amaro 

Scientific Project Manager 

Instruct-ERIC

Oxford House

Parkway Court

John Smith Drive

Oxford

OX4 2JY, UK 

Tel:+44 1865987629

email: claudia@instruct-eric.eu 

Follow us on twitter @instructhub


FEBS Advanced Course: Biomolecules in Action II. Lectures and practical exercises with focus on the latest, most applicable, and emerging bioanalytical methods applied in life sciences in order to characterize biomolecules for later studies involving novel radiation sources such as free electron lasers and complementary techniques (e.g. CryoEM).

Target audience: PhD students and young postdoctoral fellows (30 places available)

Venue: DESY and EuXFEL

Homepage: https://biomolaction2019.febsevents.org

Poster: https://biomolaction2019.febsevents.org/…/PC19-044_Poster.p…

Course organizers: Christian Betzel (Hamburg University) and Jeroen Mesters (Lübeck University)


We are pleased to make a Call for Abstracts for ADD2019, the 4th edition of the School & Conference on Analysis of Diffraction Data in real-space:

https://workshops.ill.fr/e/add2019

co-organized by the Institut Laue-Langevin (ILL) and the European Synchrotron (ESRF), and taking place:

17 to 22 March 2019

at the European Photon and Neutron (EPN) campus in Grenoble, France.

Starting from the above homepage for ADD2019, you can click on the Registration tab at left to login with your credentials (creating an account if necessary) and then register for the School part, the Conference part, or for both.

This Call for Abstracts is for those attending the Conference part, since the School part consists of only invited presentations.

Once you have registered, you can then use the Call for Abstracts tab in order to access a link for downloading the *.docx Word template for abstracts.

Please, fill out the template with the content of your abstract (only one Word file per abstract), and then go and click on the "Submit new abstract" button, which will then allow you to upload your *.docx Word file(s) and to enter other information.

Please do NOT upload an extracted *.pdf file of your abstract(s), we only need the Word file(s).

Be sure to specify, by clicking on the appropriate contribution type before submitting your abstract, whether you prefer an Oral or Poster presentation. Do not click on "Invited" unless you have already received from us an email inviting you to give an Invited Talk during the School and/or Conference.

The deadline for abstract submission is Sunday 27 January 2019, and you should receive notice of our acceptance decision by Friday 1 February 2019. If we cannot accept your abstract for an Oral presentation, then by default we will accept it for a Poster. Note that poster abstracts (only) may still be submitted until

Sunday 24 February 2019, which also corresponds to the deadline for registration and payment.

The organizers:

Michela Brunelli (DUBBLE/ESRF)

Gabriel Cuello (ILL)

Henry Fischer (ILL)

Gavin Vaughan (ESRF)


Dr. Julia Griese, Assistant Professor, Department of Cell and Molecular Biology, Uppsala University, Sweden, email: julia.griese@icm.uu.se


On behalf of the Organizing Committee, it is our privilege and special pleasure to invite you to the 9th International Conference of the Hellenic Crystallographic Association (HeCrA9), which will be held in October 5th – 7th 2018 at the Conference and Cultural Center of the University of Patras, Greece. The HeCrA9 meeting will take place in October 5-7, 2018 at the Conference and Cultural Center of the University of Patras in Greece. The conference is co-organized by HECRA, the University of Patras, the Foundation for Research and Technology and Patras Science Park. The aim of this meeting is to promote and support research and education in the fields of crystallography and structure in Greece. The forthcoming conference will include plenaries and microsymposia dedicated to recent advances in CryoEM, XFELs, synchrotrons, spectroscopic methods and other related techniques for the study of materials, inorganics, small organics and biomacromolecules, emphasizing the progress of structural sciences in recent years.

 The conference will begin with a keynote lecture by the Minister of Research and Innovation, Prof. Costas Fotakis "Building Knowledge Economy as an Antidote to Crisis" .

We sincerely believe that the HeCrA9 symposium in Patras will bring together scientists from all over the world in order to contribute to a better understanding of the role of structural studies in physics, biology, chemistry and material science. Through a careful selection of Keynote and InvitedSpeakers, the addition of emerging topics from young group leaders and the participation of young scientists we aim to shed light into recent advances in crystallography and structural studies.

The deadline for abstract submission and registration is Sunday 23d of September 2018, 23:59.

For more information, please visit the website: https://sites.google.com/view/hecra2018/call-for-abstracts

 

I would like to inform you that the Onassis Foundation Science Lecture Series 2018 - a week long summer school - in Biology and Chemistry is devoted to: "Eukaryotic Transcription and its Regulation".

Lecturers are:

Roger Kornberg (Professor, Stanford University, USA), Nobel Prize (2006) in Chemistry

Victor Corces (Howard Hughes Professor, Emory University, USA)

Claes Gustafsson (Professor, University of Gothenburg, Sweden)

Achilleas Kapanidis (Professor, University of Oxford, UK)

Roberto Mantovani (Professor, University of Milano, Italy)

Robert Roeder (Professor, Rockefeller University, USA), Lasker Award (2003) in Basic Medical Research

Jesper Svejstrup (Professor, Francis Crick Institute, UK),

Ioannis Talianidis (Director, Foundation for Research and Technology Hellas, IMBB, Greece).

The Onassis Foundation has the pleasure to announce that it can provide financial support to 35 Greeks and 15 International qualified students (post Graduate and advanced Undergraduate) to cover their travel and accommodation subsistence.

I would like to take this opportunity to ask you to encourage excellent students and young scientists from your institution to apply.  

Closing date for applications is the 12th June 2018.

Detailed information and on-line application through our website:

http://www.forth.gr/onassis/index.php?show=2018-07-16

Sincerely, 

Em. Professor I. Papamastorakis

Chairman of the Organizing Committee


https://journals.iucr.org/m/issues/2018/03/00/

https://journals.iucr.org/d/issues/2018/05/00/

http://journals.iucr.org/j/issues/2018/03/00/


21st – 24th March 2018, Zagreb, Croatia

ABSTRACT DEADLINE EXTENDED TO 5th MARCH 2018!

We have extended our original deadline to give more of you the chance to showcase your work and contribute to the Scientific Meeting “Understanding Movement and Mechanism in Molecular Machines”.

Don’t wait – make sure you are part of this in Zagreb, 21st – 24th March 2018.

For details, registration and abstract submission, please visit http://iaberd.irb.hr/

We look forward to welcoming you in Zagreb this spring for an outstanding conference.

You may read more about the conference on the web site http://molecularmachinery.eu/


Ομιλητής: Dr. Manfred Weiss (Group Leader- Macromolecular Crystallography)

Ιστοσελίδα: https://www.helmholtz-berlin.de/forschung/oe/np/gmx/index_en.html

Helmholtz-Zentrum Berlin, Germany

Τίτλος "Crystallographic fragment- screening at the HZB".

Πέμπτη 22 Φεβρουαρίου 2018 και ώρα 12:30 μ.μ.

στην αίθουσα Τηλεδιασκέψεων της Κεντρικής Βιβλιοθήκης του Πανεπιστήμιο Πατρών

Περίληψη: 

Fragments are small organic molecules, with molecular weights in the 200 Da range. Screening fragments for binding to biological macromolecules has been around for some time now and it has been promoted for the following two reasons: (i) with relatively few fragments, one can to cover a large chemical space and (ii) being rather small, fragments are amenable to optimization by simply enlarging them. Typically, binding fragments are identified by a cascade of biophysical methods and then further analyzed structurally by X-ray crystallography. The major pitfall of this approach is that pre-screening methods tend to disagree with each other in particular for weakly binding entities, which fragments typically are. Consequently, pre-screening seems little effective and leads at best to an enrichment of potential binding hits.

On the other hand, recent advances in synchrotron technologies, X-ray detectors and automated processing of diffraction data have made it possible to collect and process in excess of several hundreds of diffraction data sets per day. This level of throughput has made it possible to use the method X-ray crystallography as a (or the) primary screening technique. In the talk, I will discuss a large fragment-screening study (361 compounds vs. the protease endothiapepsin), as well as some results using a new small, affordable and versatile compound library, which we have recently assembled at the HZB and which is available to the HZB-MX beamline users. Further, I will show the MX-facilities at the HZB, including a new X-ray crystallography beam line dedicated to fragment screening experiments, which is currently being completed at the BESSY II synchrotron. Finally, in order to facilitate high-throughput crystallography I will also show an example for the efficient identification of fragment hits.


http://www.helmholtz-berlin.de/user/beamtime/proposals/index_en.html 

Hereby we would like to invite the submission of new proposals for 

MX-beamtime at the HZB-MX beamlines for the next beam time period 

(08/2018-01/2019). 

In order to apply for beamtime, please register at the HZB on-line 

access tool "GATE" (https://www.helmholtz-berlin.de/pubbin/hzbgate) 

and submit a new beam time application proposal. 

HZB provides MX-beamtime at the three MX-beamlines BL14.1, BL14.2 

and BL14.3. The three beamlines are equipped with state-of-the-art 

instrumentation and are currently the most productive MX-stations 

in Germany with over 300 PDB depositions annually. Beamtime is 

granted based on the reviewed proposals and on reports from 

previous research activities. Please make sure to include them 

if available. 

What's new: Due to a planned upgrade of the experimental endstation

                        BL14.3 will not be fully available. Details can be provided

                        upon request.

Experimental setup: 

BL14.1: 

- Photon flux: 1.4x10¹¹ Phot/sx100mAx0.05%BW at sample position 

  (0.1-1 sec exposure time per frame) 

- User defined beam shaping from 50µm-100µm diameter possible 

- Pilatus 6M detector, 141mm-680mm max. distance from the sample 

- Microdiffractometer (MD2) with Mini-kappa goniometer MK3 

- Automatic sample changer (CATS), 90 sample storage capacity 

 (SPINE-Pin & EMBL sample magazine compatibility) 

- 32-core XEON-CPU server, with 10Gb uplink to Pilatus 6M 

- Data collection control via MXCuBE 

- EDNA 

- Common MX-software installed including XDS, iMOSFLM, CCP4, 

  Phenix, SHELXC-D-E, etc. 

- Automated data processing with XDSAPP 

- Remotely controlled cryo-shutter for crystal annealing 

- Pressure chamber for noble gas derivatization (Xe, Kr 

  available upon request) 

- AMPTEK-XRF detector and XFEPLOT software available 

We are also offering the hard- and software environment for 

carrying out: 

- UV-RIP experiments at BL14.1. For further information, please visit: 

https://www.helmholtz-berlin.de/forschung/oe/np/gmx/ancillary-facilities/uvrip_en.html

BL14.2: 

- Photon flux: 1.9x10¹¹ Phot/sx100mAx0.05%BW at sample position 

  (0.1-1 sec exposure time per frame) 

- Pilatus 3S-2M detector with 1000 micron Si sensor thickness, 

  55mm-600mm distance from the sample 

- Nanodiffractometer (DESY P11 design) and on-axis sample microscope 

- User defined beam shaping from 30µm-150µm diameter possible 

- GROB sample changer for SPINE and UNIPUCK support 

- 60-core XEON-CPU server, with fibre channel SAN up-link data 

  processing environment 

- Common MX-software installed including XDS, iMOSFLM, CCP4, Phenix, 

  SHELXC-D-E, etc. 

- Automated data processing with XDSAPP 

- Amptek XRF detector 

- Pressure chamber for noble gas derivatization (Xe, Kr available 

  upon request) 

- Ultra high performance stereo microscope Leica M205A, 20-255x zoom, 

  8 Mpixel CCD-camera 

- UV-Microsprectrophotometer offline setup available 

- AMPTEK-XRF detector and XFEPLOT software available 

BL14.3: 

- Photon flux: 4x10exp10 Phot/sx100mAx0.05%BW at sample position 

  (3-20 sec exposure time per frame) 

- Rayonix MX-225 X-ray detector, 45mm-380mm distance from the 

  sample, 30 deg 2-Theta possible 

- MARdtb goniometer 

- 60-core XEON-CPU server, with fibre channel SAN up-link data 

  processing environment 

- EDNA installed and available 

- Common MX software installed including XDS, iMOSFLM, CCP4, Phenix, 

  SHELXC-D-E, etc. 

- Automated data processing using XDSAPP 

- Remotely controlled cryo-shutter for crystal annealing 

- HC1c dehydration device installed (please specify HC1-beamtime 

  in your proposal if needed) 

- Pressure chamber for noble gas derivatization (Xe, Kr available 

  upon request) 

- Ultra high performance stereo microscope Leica M205A, 20-255x zoom, 

  8 Mpixel CCD-camera 

S1-biolab facilities (separate registration required): 

- Protein production and purification 

- Nanoliter 96 well crystallization plate formulation and storage at 

  5 °C and 20 °C 

- Biophysical characterization with real time PCR (thermofluor assay) 

The HZB-MX group is also providing expert assistance as well as 

access to a library of fragments for carrying out crystallographic 

fragment-screening experiments. For more information please contact 

msweiss@helmholtz-berlin.de. 

Please visit our web page www.helmholtz-berlin.de/bessy-mx to obtain 

updated information about our experimental setup and other 

requirements. 


For more details, visit http://molecularmachinery.eu/upcoming-events/ and look at the attached flyer.


I remind you that the deadline for abstract is February 25, and I ask you to encourage the members of your Working groups to register as well, that we can ensure equal representation of MCs and reimbursement for young PI from all countries.


Please use the link to register and submit your abstract for this meeting http://iaberd.irb.hr/.


The conference team is looking forward to welcome you in Zagreb and appreciate your participation which will make 4th International Scientific Meeting an excellent meeting.

 Topics to be covered will include:

 Lectures will be given by Prof. John Evans, Dr. Ivana Evans, Dr. Jeremy Cockcroft and Prof. Andy Fitch.

 


Groups applying for beamtime to work on several projects in MX and SAXS are strongly encouraged to submit BAG (Block Allocation Group) proposals. If you wish to renew an existing BAG proposal, you will be requested to complete a progress report or a full two-year report before submitting your proposal. Mail-in proposals for the use of robotic sample changer are encouraged for SAXS. 

A detailed description of the three beamlines and links to the electronic proposal forms can be found at: 

SAXS: http://www.embl-hamburg.de/services/saxs/index.html

MX: http://www.embl-hamburg.de/services/mx/index.html 

Submit a proposal via the EMBL Hamburg user portal 

Access to the EMBL Hamburg facilities also includes assistance with crystallisation, sample preparation and, in combination with an EMBL beamline visit, with sample characterisation and optimisation. 

Usage of the beamlines and biophysical facilities for translational research can in part be supported by the iNEXT project (http://www.inext-eu.org/access/) of the Horizon 2020 programme of the European Union. 

For further general information, please contact the EMBL Hamburg user office:

Tel.: +49 40-89902-111 / 183

Email: useroffice (at) embl-hamburg.de 

For specific information:

saxs (at) embl-hamburg.de (small-angle X-ray scattering)

mx (at) embl-hamburg.de (macromolecular crystallography)

spc (at) embl-hamburg.de (sample preparation and characterization) 


The meeting is aimed at giving the audience an insight into the "joy and pain" of protein crystallographic/structural biology research. Speakers have been asked to choose a particular piece of published work from any stage of their career and speak about the "real" story behind it - the people, the chance meeting, the experimental process, the 100's of failed trials that eventually led to "perfect" experiments, etc. The aim here is to give the audience a deeper insight into the processes that lead to the wonderful science that structural biology reveals.

Programme:

Professor Malcolm Longair, Cavendish Laboratory, "Decline and Regeneration: the Cavendish Laboratory 1932 to 1953 and the Development of Molecular Biology"

Professor Judith Howard, Durham University, "Early diffraction experiment at low temperature - with reference to a PRS paper on unstable Pt species"

Sir Tom Blundell, University of Cambridge, "Joy and Pain in Nature and Science: Structural biology of DNA-PK and DNA Double-strand-break Repair"

Professor Randy Read, University of Cambridge, "The road to ab initio phasing by molecular replacement"

Dr. Pamela Williams, Astex Pharmaceuticals, "Crystal structure of human cytochrome P450 2C9 with bound warfarin"

Dr. Ben Bax, York Structural Biology Laboratory"Structural studies in support of the development of new antibiotics targeting DNA gyrase and the development of oligonucleotide topoisomerase inhibitors (OTIs)"    

Professor Janet Thornton, European Bioinformatics Institute, "Of Exploration and Errors - PROCHECK - an 'accidental' paper"

Dr. Richard Henderson, MRC Laboratory of Molecular Biology, "The struggle to get high resolution phases for 2D crystals of bacteriorhodopsin - pain, joy, more pain, more joy"



 The meeting provides a review of state of the art profile fitting analyses using TOPAS, hosting a program of invited speakers. The major component is to demonstrate TOPAS's outstanding modeling methods and related applications in X-ray and neutron diffraction. Participation is open for anyone, TOPAS users and non-users, interested in learning more about the TOPAS capabilities and applications. Participants are encouraged to submit discussion topics in advance to the organizers. The final schedule will take issues of general interest into account. Presentations and example data used will be distributed to the participants as made available by the speakers.

 The 14th TOPAS Users’ Meeting preceeds the 16th European Powder Diffraction Conference (EPDIC16) held in Edinburgh, UK: http://epdic16.efconference.co.uk/

 We will focus on the following 3 topics:

- Crystal structure determination and refinement

- Microstructure analysis, specifically WPPM

- Pair distribution function analysis

 The detailed program will be published in the 2nd announcement beginning of 2018.

 Organizers:

Arnt Kern, Bruker AXS, Germany

Anja Griessmeier, Bruker AXS, Germany

 Location:

Radisson Blu Edinburgh

80 High Street, Edinburgh, EH1 1TH, UK

Tel: +44 131 557 9797

Fax: +44 131 557 9789

https://www.radissonblu.com/de/hotel-edinburgh

Email: info.edinburgh@radissonblu.com

          

For more information and registration please go to https://www.bruker.com/pt/events/users-meetings/x-ray-diffraction-and-elemental-analysis/topas-users-meeting.html

 


στα πλαίσια χρηματοδοτούμενων ερευνητικών προγραμμάτων. 

Οι Υ/Δ θα πρέπει να έχουν πτυχίο από τμήμα Φαρμακευτικής, Χημικών Μηχανικών, Χημείας, Βιολογίας ή άλλο συναφές, και πολύ καλή γνώση Αγγλικών. 

Οι υποψήφιοι ΜΕ θα πρέπει να έχουν διδακτορικό δίπλωμα από τμήμα Φαρμακευτικής, Χημικών Μηχανικών, Χημείας, Βιολογίας ή άλλο συναφές και πολύ καλή γνώση Αγγλικών, ενώ είναι επιθυμητή η εμπειρία σε αναλυτικές τεχνικές, τεχνικές παρασκευής και χαρακτηρισμού νανοσωματιδίων, τεχνικές μικροσκοπίας και καλλιέργειας κυττάρων. 

 

Σχετικά με τα προγράμματα:

  

1] Στα πλαίδια του Εργου: Καινοτόμα ΣΥστήματα για ΣΤΟχευμένη και ελεγχόμενη χορήγηση ΦΑΡμάκων ή/και απεικονιστικών ουσιών θα γίνει ανάπτυξη καινοτόμων θεραπευτικών συστημάτων για θεραπεία ή/και διάγνωση ασθενειών, με την εφαρμογή της νανοτεχνολογίας και της συνδυαστικήςχρήσης προηγμένων βιοϋλικών και απεικονιστικών μεθόδων. Συνδυάζοντας δομικά συστατικά με αντικαρκινική δράση, με άλλα που αυξάνουν την διάρκεια κυκλοφορίας νανοσωματιδών στο αίμα, ΘΑ ΑΝΑΠΤΥΧΤΟΎΝ ΠΡΟΗΓΜΈΝΕΣ (ΝΑΝΟ)ΜΟΡΦΈΣ ΧΟΡΉΓΗΣΗΣ χημειοθεραπευτικών φαρμάκων. Στην επιφάνεια των ΝΣ, θα ακινητοποιηθούν μόρια-προσδέτες που θα επιλεγούν βάσει πρόσφατων δεδομένων σχετικά με τις οργανοτροπικές ιδιότητες εξωκυτταρικών κυστιδίων.


2] Στα πλαίσια του Έργου ΠΡΟΚΛΙΝΙΚΗ ΑΝΑΠΤΥΞΗ ΚΑΙΝΟΤΟΜΩΝ ΝΕΥΡΟΠΡΟΣΤΑΤΕΥΤΙΚΩΝ ΚΑΙ ΝΕΥΡΟΑΝΑΓΕΝΝΗΤΙΚΏΝ ΣΥΝΘΕΤΙΚΩΝ ΜΙΚΡΟΝΕΥΡΟΤΡΟΦΙΝΩΝ (ΜΝΤ) ΚΑΤΑ ΤΗΣ ΝΟΣΟΥ ALZHEIMER (ΑD), για την αποτελεσματικότερη στόχευση της νέας θεραπείας της AD, θα μελετηθεί η χρήση νανοσωματιδίων ως όχημα μεταφοράς τους στον εγκέφαλο, μέσω εγκλεισμού τους σε λιπιδικά νανοσφαιρίδια φέροντα προσδέτες με χημική συγγένεια για το β-αμυλοειδές. Θα μελετηθεί η φαρμακοκινητική /εντοπισμός στον εγκέφαλο μετά από χορήγηση των νανοσωματιδίων-ΜΝΤ (σε σύγκριση με τα ελευθερα μόρια), σε ζωικό μοντέλο 5xFAD της AD που θα προσδιορισθεί με χρωματογραφικές μεθόδους αιχμής.

Παρακαλούνται οι ενδιαφερόμενοι να επικοινωνήσουν με την Καθ. κ. Σοφία Αντιμησιάρη (santimis@hotmail.com; 2610-962332).


We would like to invite you to our Cryo-EM User Symposium on 2nd February 2018 at EMBL Heidelberg to inaugurate the new cryo-EM User facility housing FEI Titan Krios and Talos Arctica microscopes. The EMBL Heidelberg cryo-EM user facility will further increase access to cryo-EM.

Speakers that have already used our cryo-EM facility at EMBL Heidelberg will present their research during the symposium. The symposium will start at 11.00 h and will finish with a reception at 19.00 h. We will also dedicate time to discuss future needs and potential improvements of the facility. The preliminary schedule can be found at:

http://www.sachse.embl.de/emspring/_download/cryo_user_schedule.pdf

Registration is for free. Please make your own travel and lodging arrangements. Places are limited. Poster presentations are welcome. Please register for the meeting by 31st December 2017 using this link:

https://www.surveymonkey.de/r/cryo_em_user_symposium

Additional information can be obtained by Alena Froehlichova (alena.froehlichova@embl.de).

We are looking forward to a stimulating meeting and your attendance!

Best regards,

Julia Mahamid, Christoph Müller, Martin Beck and Carsten Sachs

-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠

Dr. Christoph W. Müller

Head of Structural and Computational Biology Unit

EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany

email: cmueller@embl.de, phone: 0049-⁠6221-⁠387-⁠8320

fax: 0049-⁠6221-⁠387-⁠519, http://www.embl.de

http://www.embl.de/research/units/scb/mueller_christoph/index.html

-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠ 

Training School: Advanced fluorescence methods to explore dynamics and mechanisms of molecular machines

7-9 February 2018, Parma, Italy

Organizers: Claus Seidel, Andrea Mozzarelli and Serena Faggiano

An integrated approach combining complementary spectroscopies and molecular simulations. The course will provide an in-depth theory and practice of fluorescence spectroscopy for the investigation of complex biological systems. Other spectroscopic methods will be covered in order to describe complementary approaches for structural modelling.

Registration open until 20th December 2017

For more information follow the link:

http://molecularmachinery.eu/advanced-fluorescence-methods/


During the 2018 User Meeting (5-7 February), the ESRF will hold a microsymposium dedicated to High Pressure Science.

In the coming years, the ESRF will embark on a modernization project – The Extremely Brilliant Source (ESRF – EBS). The high pressure community put forward several projects in order to take full benefit from the EBS. In parallel, several beamlines were recently improved or constructed. As such, there is a need to present the new opportunities in high pressure science at the ESRF.

The microsymposium programme will consist in presentations featuring the latest scientific and instrumental news from the diffraction (BM01, ID06LVP, ID15B, ID27), absorption (BM23, ID12, ID24) and inelastic scattering (ID20, ID28) beamlines and will provide many opportunities for scientific discussions and feedback on the proposed beamline refurbishments.  It will, also, be an opportunity for the high pressure community to discuss high pressure science at ESRF.

We encourage you to submit abstracts and attending this workshop. Your participation is a key for the success of the meeting but also to show your support to high pressure science at the ESRF.

The abstracts should be submitted by mail to udm1-um18@esrf.fr using the attached template.

You find more information on the UDM1 web page:

http://www.esrf.fr/home/events/conferences/2018/user-meeting-2018/Microsymposia/UDM1/udm1-call-for-abstracts.html

Deadlines:

- abstract submission: 10 December 2017

- user registration: 21 January 2018

Sébastien Merkel, Roberta Angelini (ESRF, User Organisation Committee),

Mohamed Mezouar (ESRF), microsymposium organisers


 As in previous years, we will offer a combination of lectures covering the theoretical aspects of powder diffraction and Rietveld refinement, classroom-based “by-hand” problem sessions/tutorials and extensive hands-on practical sessions using a variety of modern software packages. Topics to be covered will include:

Lectures will be given by Prof. John Evans, Dr. Ivana Evans, Dr. Jeremy Cockcroft and Prof. Andy Fitch.

 Online applications can be submitted until 19 January 2018 at the Powder Diffraction & Rietveld Refinement School 2018 website: community.dur.ac.uk/john.evans/webpages/riet_register.htm


28 Years of Neutron & Synchrotron Radiation Science

2018 session:   25 February-30 March, 2018

DEADLINE FOR APPLICATION: 15 October, 2017

    HERCULES is a European course for PhD students and young researchers using Neutrons and Synchrotron Radiation for applications in Biology, Chemistry, Physics, Hard & Soft Condensed Matter.

    The 1-month school includes lectures (60%), hands-on practicals and tutorials at partner institutes (Elettra and FERMI in Trieste, Italy, ESRF, ILL in Grenoble, Soleil and LLB in Paris-Saclay, PSI in Villigen, Switzerland) and Grenoble Laboratories (CEA, CNRS, EMBL, IBS). (*)

(*)  also, participation of DESY and the European XFEL to be confirmed for 2018 due to scheduled down-time.

    The school  includes a common part and two parallel sessions:

- Biomolecular, soft condensed matter structure & dynamics

- Physics and chemistry of condensed matter

        Why join Hercules ?

- to learn new techniques using neutron and synchrotron radiation

- to expand your theoretical and practical knowledge, not only for your present research but for your scientific career

- to experiment these techniques on world-class instruments & beamlines

- to build a network of relations with fellow young researchers and experienced teachers from all around the World

    Bursaries/reduced costs

- A limited number of bursaries will be available either to reduce registration fees or cover travel costs.

    More information: (see programme overview below)

Contact email: hercules@hercules-school.eu



I would like to draw attention to the availability of enhanced support for sample preparation and characterization for SAXS and macromolecular crystallography at EMBL Hamburg. For SAXS, this includes biophysical characterization and optimization of samples, access to the P12 BioSAXS beamline and, if needed, assistance in  data analysis. For MX, 

the access includes high-throughput crystallization, automatic crystal harvesting and data collection on the EMBL beamlines P13 and P14. 

The point of access for support is the Sample Preparation & Characterization (SPC) facility: 

https://www.embl-hamburg.de/services/spc/index.html 

Researchers within the European research area can apply for sponsored access through iNEXT, which includes sample shipment, travel from the home lab and all consumables: 

http://www.inext-eu.org/access/ 

To obtain iNEXT access, a proposal should be submitted that describes the 

biological background and translation research component of the project. 

Interested scientists are encouraged first to contact the facility at spc@embl-hamburg.de. 

Rob Meijers 



Στα πλαίσια του Προγράμματος Μεταπτυχιακών Σπουδών στο Τμήμα Βιολογίας του Πανεπιστημίου Πατρών, Κατεύθυνση "Βιολογική Τεχνολογία", την Τρίτη 26/09/2017, 11.00, στην αίθουσα σεμιναρίων (Ισόγειο Κτιρίου), η φοιτήτρια κ. Μαγδαληνή Χριστοπούλου θα παρουσιάσει την διπλωματική της εργασία με θέμα:

Παραγωγή και Δομικός Χαρακτηρισμός Ιικών Πρωτεϊνών και

Νέων πολυμόρφων Ινσουλίνης

(https://drive.google.com/open?id=0B8B9t1F96bWKWmVqeF9ZTGF3N2c)

Επιβλέπουσα Επικ. Καθηγήτρια: Ε. Μαργιωλάκη. Μέλη της Εξεταστικής Επιτροπής: Καθ. Χ. Γεωργίου, Επικ. Καθ. Ε. Ροσμαράκη (Τμήμα Βιολογίας)

 

Although a stand-alone course, the postgraduate certificate in protein crystallography can also be taken as part of the MSc in Structural Molecular Biology. For more details, please see http://www.bbk.ac.uk/study/2017/postgraduate/programmes/TMSBISCL_C/

-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠-⁠

Dr Tracey Barrett,

Crystallography,

Senior Lecturer in Structural Biology,

Institute for Structural and Molecular Biology,

Birkbeck College,

Malet Street,

London WC1E 7HX

Tel: 020 7631 6822

Fax: 020 7631 6803 


http://journals.iucr.org/m/issues/2017/05/00/tj5011/index.html






The powder diffraction teams from the Australian Synchrotron and OPAL are hosting a 3 day powder diffraction data analysis workshop for beginners aimed at post-graduate students and early career researchers.

This workshop aims to cover proposal writing for synchrotron X-ray and neutron diffraction experiments, experiment preparation including data collection strategies, and basic data analysis techniques commonly used with X-ray and neutron powder diffraction data sets. 

Topics will include: basic crystallography, experiment preparation, peak indexing, phase search-matching, whole pattern fitting (Rietveld refinement), geometry corrections, proposal writing guides and an introduction to advanced analysis techniques. Tutorial sessions will be used to practically reinforce the material presented.

Tutorials will be split into 2 parallel sessions: one using TOPAS and one using GSAS II.

Priority will be given to applicants with synchrotron or neutron data or those applicants with awarded beamtime.

Lectures and tutorials will be presented by the AS beamline team, Dr Helen Maynard-Casely (ACNS, ANSTO), Dr. Nathan Webster (CSIRO) and Dr Matthew Rowles (Curtin University)

Location

The workshop will be held at the Australian Synchrotron, 800 Blackburn Rd, Clayton, Victoria.

Date

4th – 6th September, 2017

Program

Lectures and tutorials will be presented. A preliminary programme is available here.

Accommodation and Meals

Participants travelling from regional Victoria, interstate and overseas will be provided with accommodation at the Australian Synchrotron Guesthouse.

The Guesthouse is located on-site at the Australian Synchrotron, 800 Blackburn Road, Clayton VIC 3168.  .

Lunch and morning/afternoon tea will be provided for all participants.  Dinner will also be provided for all participants on the evenings of the 4th and 5th.  Travel assistance will not be provided.

Expressions of Interest

If you are interested in attending, please register an expression of interest here: https://events.synchrotron.org.au/event/60/

Registration will close on the 7th August and applicants will be notified of the outcome of their EOI on the 11th August 2017.

Places are limited to 30.

If there are questions please contact the Workshop Team at this email address: pdworkshop@synchrotron.org.au

 Justin Kimpton




Registration for the event is now closed, but you can follow the talks, presented by worldwide experts in the field, through YouTube live streaming:

https://www.youtube.com/user/LightforScience

We will be live from 1.30pm on 6 July 2017.

Check out the programme here: http://www.esrf.eu/cryo-em.fr

On behalf of the Organising committee: Stephen Cusack (EMBL), Trevor Forsyth (ILL/Keele), Wojciech Galej (EMBL), Gordon Leonard (ESRF), Marco Marcia (EMBL), Christoph Mueller-Dieckmann (ESRF), Hugues Nury (IBS), Guy Schoehn (IBS), Montserrat Soler-Lopez (ESRF), Jean Susini (ESRF) and Winfried Weissenhorn (IBS).

Dr. Marco MARCIA, EMBL Grenoble, 71 Avenue des Martyrs, room 254, 38042 Grenoble Cedex 09

France, phone (lab): 0033-(0)47620-7634/7040

phone (office): 0033-(0)47620-7759, email: mmarcia@embl.fr

web: https://embl.fr/research/unit/marcia/ 



A Conference on the «Structural biology and biophysics of RNA-protein complexes» will be held on the 13th to 15th November 2017 in Orléans, France. Crystallographic studies will be a major focus of this Conference.

If you wish to participate, please have a look and register at the Conference web page:

http://www.lestudium-ias.com/…/structural-biology-and-bioph…

We are looking forward to welcoming you to Orléans, in the beautiful Loire Valley, this fall.

On behalf of the organizing committee,

Marc Boudvillain and Emmanuel Saridakis




Response- By "cursor" do yo mean the  rotation centre marker?  Let's imagine that you do. Coot will place the ligand close to the centre of the screen if you activate the "Right Here" button.  If you don't do so, it will search the whole asymmetric unit and try to map the model position back to somewhere close to the protein.  This can be slightly hit and miss (depending on the position of the protein in relation to the asymmetric unit). If you want to change the position of the fitted ligand to a symmetry related one, you can (1) centre on the symmetry-related ligand (2) use Extensions -> Modelling -> Symm Shift Reference Chain Here.






users in the drug discovery field would have been aware of it, as many

of them use both Phenix and BUSTER. An even more explicit and detailed description of that feature,

dated March 2011, may be found at http://www.globalphasing.com/buster/wiki/index.cgi?LigandDetectionModes

          Gerard.

On Thu, Feb 16, 2017 at 07:17:23AM -0800, Pavel Afonine wrote:

Dear Gerard, Thank you so much for letting us know of the reference and details about

your long-standing BUSTER method for ligand density maps which we now see is very similar to our recent polder map method.  We apologize for not being aware of the early reference and we will be very sure to cite it in future publications.







(http://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/software.html) In there, Refmac reports an average FSC value which is way more useful than the R-factor. But you always have to make sure to not do overfitting. You will have to test for overfitting as it is described and done for example in the most recent publications of Venki Ramakrishnan.


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As all of you know, the European Crystallographic Association promotes training and education of the next generation of crystallographers by organizing a European School every year, on basic and advanced themes, addressed to PhD students and young researchers. The success of the previous schools (Pavia, Oviedo and Bol) clearly shows that a network of young enthusiastic people is joining our community. The next School, ECS4 will be held in Poland, in 2 – 7 July 2017. I would like to invite you to read the invitation message from the organizers of ECS4, attached to this mail, and to suggest to your students and young colleagues to consider taking  part in this school. Prof. Alessia Bacchi

President of the European Crystallographic Association Dipartimento di Chimica University of Parma Viale delle Scienze, 17A - Campus, I-43124 Parma, Italy Tel. +39 0521 905421 Fax  +39 0521 905557 e-mail alessia.bacchi@unipr.it http://www.unipr.it/ugov/person/21095