• Note: models in Zbrush are referred to as tools.
• Clear Active Layer - Ctrl N
• Always remember to put a model in edit mode so that I can fully interact with it.
• Use Lightbox to load in stuff such as model presets.
• Tool Tips - Ctrl hover
• Show/ hide pallet - 'Tab' key
• Rotate - Click and drag on an open area
• Move - Alt Click and drag
• Zoom - Alt Click and drag then release Alt whilst still Clicking (or +/- key)
• Centre Mesh in Canvas - F
• Having Perspective turned on is useful, Floor as well to stay orientated.
• Turn on Symmetry - X (can be tweaked in transform menu)
• Constrain to 90o rotations - Click, Drag Shift
• Expose - Shift X
• Draw Polyframe - Shift F
• Delete Zsphere - Alt, Click on Zsphere
• Preview Adaptive skin - A
• Create mask - Ctrl click on model
• Clear Mask - Ctrl, Shift, A
• Brush size - [ or ]
• Show Brush Pop Up - B
• Standard Brush - B,S,T
• Zsubtract - Ctrl, Shift, A
• 
  

Reached:

Setting the stroke properties

and

Using ZSpheres to create basic anatomy

FromSculpting a Creature with ZBrush and Photoshop