In Runaways Season 2, there is a small reference to Kirk Skadden, a S.H.I.E.L.D. agent who appeared in the first episode of Agents Of S.H.I.E.L.D.

There is a very subtle reference to Gravitonium in Runaways Season 2.

The same WHIH reporter from Runaways Season 2 is also seen in Agents Of S.H.I.E.L.D. Season 4.

The Darkhold appears in Runaways Season 3, with the same appearance he had in Agents Of S.H.I.E.L.D. season 4.

Aubrey Joseph and Olivia Holt return to play Tyrone Johnson / Cloak and Tandy Bowen / Dagger, respectively, in some episodes of Runaways Season 3.

The Loa of the Dark Dimension are mentioned.