The WHIH Newscast and Roxxon Corporation are seen at various points in the series.

At some points in the early seasons of the series, Culver University is mentioned, the place where Bruce Banner, Betty Ross, and Samuel Sterns studied, as well as Victor and Janet Stein, Chase Stein's parents.

The "Hudson Rubbish & Disposal" garbage collection service is seen in some episodes of Daredevil.

Tina Minoru reappears after her cameo in the Doctor Strange movie. Additionally, the Staff of One is seen in the Hong Kong Sanctuary, an important weapon carried by Tina Minoru and later by her daughter, Nico Minoru.

By using the Staff of One, we can see that Nico Minoru gets the same marks on his eyes as Kaecilius and his followers when using Dark Dimension magic.

Tina Minoru mentions the Crimson Bands of Cyttorak.

Time Travel is depicted in the series differently than Avengers: Endgame, but connects with what Karl Mordo said in Doctor Strange about the possible consequences of time traveling, which includes erasing yourself from existence.

In Runaways Season 3, the group ventures into the Dark Dimension.

In Runaways Season 2, Alex Wilder mentions Wakanda.