Publications

Selected publications

1. Marcangeli V*, Girard-Côté L*, Di Leo V, Roussel MP, Lawless C, Charest O, Argaw A, Dulac M, Hajj-Boutros G, Morais JA, Vincent A, Gouspillou G, Leduc-Gaudet JP#, Duchesne É#. A 12-week strength training improves mitochondrial respiration, H2O2 emission and skeletal muscle integrity in women with myotonic dystrophy type 1. Accepted in Acta Physiologica. * These authors contributed equally to this work (co-first authors). #Corresponding author https://onlinelibrary.wiley.com/doi/10.1111/apha.70135 

2. Morin E, Doumard E, Hartnell LM, Salegi Ansa B, Leduc-Gaudet JP, Quillien A, Nakhle J, Ethuin S, Goudounèche D, Payré B, Soldan V, Balor S, Mattout A, Rouquette J, Dubois L, Sengenès C, Planat V, Casteilla L, Yart A, Dray C, Aligon J, Ferrucci L, Duchesne É, Hussain S, Gouspillou G, Formentini L, Mourier A, Baris OR, Valet P, Parpex H, Monsarrat P, Vigneau M, Pradère JP. EMito-Metrix, a turnkey pipeline for an automatic evaluation of mitochondria 2 morphology across species: from TEM imaging to computed data. Nature Metabolism.  https://pubmed.ncbi.nlm.nih.gov/41094017/ 

3. Kathryn J, Hajj Boutros G, VSonjak, Leduc-Gaudet JP, Broring F, Robb Flynn C, Chevalier M, Lamarche M, Hussain S, Morais JA. Resistance training, but not leucine, increased basal muscle protein synthesis and reversed frailty in older women consuming optimized protein intake. GeroScience. https://pubmed.ncbi.nlm.nih.gov/40926079/ 

4. Marcangeli V; Cefis M; Hammad R; Granet J; Leduc-Gaudet JP; Gaudreau P; Aubertin-Leheudre M; Bélanger M; Robitaille R; Morais JA; Gouspillou G. Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans. Aging Cell. https://doi.org/10.1111/acel.70191

5. Cefis M, Marcangeli V, Hammad R, Granet J, Leduc-Gaudet JP, Gaudreau P, Trumpff C, Huang Q, Picard M, Aubertin-Leheudre M, Bélanger M, Robitaille R, José Morais, Gouspillou G. Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men. Cell Reports Medicine. https://doi.org/10.1016/j.xcrm.2025.101968

6. Desjardins K, Taherkhani S, Méthot L, Castonguay V, Leduc-Gaudet JP. (2024) Insights into the influence of high-intensity interval training on skeletal muscle clock gene expression in insulin-resistant individuals. Journal of physiology https://doi.org/10.1113/JP286939 

7. Roussel MP, Ravel-Chapuis A, Gobin J, Jasmin BJ, Leduc-Gaudet JP, Gagnon C, Duchesne E. (2024) Changes in Physiopathological Markers in Myotonic Dystrophy Type 1 Skeletal Muscle: A 3-Year Follow-up Study. Journal of Neuromuscular Diseases

8. Sedraoui S, Leduc-Gaudet JP, Mayaki D, Moamer A, Huck L, Gouspillou G, Petrof B, Hussain SNA. (2024) Lack of compensatory mitophagy in skeletal muscles during sepsis. Journal of physiology https://doi.org/10.1113/JP286216

9. Girard-Côté L, Gallais B, Gagnon Cynthia, Roussel MP, Morin M, Hébert LJ, Monckton D, Leduc-Gaudet JP, Gouspillou G, Macangelli V, Duchesne E. (2024) Resistance training in women with DM1: a multisystemic therapeutic avenue. Neuromuscular Disorders https://doi.org/10.1016/j.nmd.2024.05.009

10. Cefis M, Dargegen M, Marcangeli V, Taherkhani S, Dulac M, Leduc-Gaudet JP, Mayaki D, Hussain SNA, (2024) Gouspillou G. MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H2O2 emission.  Acta Physiologica https://doi.org/10.1111/apha.14119

11. Leduc-Gaudet JP#, Miguez K, Cefis M, Faitg J, Moamer A, Chaffer TJ, Reynaud O, Broering FE, Shams A, Mayaki D, Huck L, Sandri M, Gouspillou G#, Hussain SNA#. Autophagy ablation in skeletal muscles worsens sepsis-induced muscle wasting, impairs whole-body metabolism, and decreases survival. #Auteur correspondant. (2023) IScience https://www.sciencedirect.com/science/article/pii/S2589004223015523 

12. Leduc-Gaudet JP, Guirguis C, Sincennes MC. Emerging links between metabolism and epigenetic regulation of muscle stem cells. (2023) Med Sci (Paris) PMID: 37387661

13. Franco-Romero A*,Leduc-Gaudet JP*, Hussain SNA, Gouspillou G, Sandri S. PHAF1/MYTHO is a novel autophagy regulator that controls muscle integrity. *Co-premier auteur. (2023) Autophagy PMID: 37309183

14. Leduc-Gaudet JP*, Franco-Romero A*, Broering F, Cefis M, Moamer A, et al. MYTHO: a novel regulator of skeletal muscle autophagy and integrity. *Co-premier auteur. (2023) Nature Communications PMID:36864049

15. Reynaud O, Wang J, Ayoub MB, Leduc-Gaudet JP, Mayaki D, Dulac M, Hussain S, Bergeron R, and Gouspillou G. The impact of high fat feeding and Parkin overexpression on skeletal muscle mass, mitochondrial respiration and H2O2 (2022) American Journal of Physiology-Cell Physiology PMID:36571445

16. Leduc-Gaudet JP, Hussain SNA, Gouspillou G, (2022) Parkin: A potential target to promote healthy aging. The Journal of physiology PMID:36571445

17. Gusev E, Liang F, Bhattarai S, Broering F, Leduc-Gaudet JP, Hussain SNA, Radzioch D, and Petrof B. (2022) Characterization of skeletal muscle wasting pathways in diaphragm and limb muscles of cystic fibrosis mice. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology PMID:35411814

18. Leduc-Gaudet JP and Hussain SNA, (2022) Muscle wasting in COPD: Not enough autophagy? American Journal of Respiratory Cell and Molecular Biology PMID:35294850

19. Chaffer T, Cefis M, Leduc-Gaudet JP, Circadian control of skeletal muscle adaptations to exercise. The Journal of physiology PMID:34339519

20. Leduc-Gaudet JP#, Hussain SNA, Barreiro E, and Gouspillou G. (2021) Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging. #Auteur correspondant. International Journal of Molecular Sciences PMID:34360946

21. Dulac M, Leduc-Gaudet JP, Cefis M, Ayoub MB, Reynaud O, Shams A, et al. (2021) Regulation of muscle and mitochondrial health by the mitochondrial fission protein Drp1 in aged mice. The Journal of physiology PMID:34269418 

22. Leduc-Gaudet JP, Miguez K, Cefis M, Moamer A, Chaffer TJ, Faitg J, et al. Role of autophagy in sepsis-induced skeletal muscle dysfunction, whole-body metabolism, and survival. (2021) bioRxiv

23. Klionsky, D. J., (...) Leduc-Gaudet JP, (...) et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy PMID:33634751 

24. Leduc-Gaudet JP, Mayaki D, Reynaud O, Broering F, Chaffer T, Hussain SNA and Gouspillou G.(2020) Parkin Overexpression Attenuates Sepsis-Induced Muscle Wasting. Cells PMID: 32545383

25. Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub M.B, Guérin A, Finkelchtein M, et al. (2020). Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation. The Journal of physiology PMID: 32539155

26. Janice Sanchez B, Tremblay, AK, Leduc-Gaudet JP, Hall DT, Kovacs E, Ma JF, Mubaid S, Hallauer, et al. (2019). Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy. Nature Communication PMID: 31519904

27. Leduc-Gaudet JP*, Reynaud O*, Hussain SNA, Gouspillou G. (2019) Parkin overexpression protects from aging-related loss of muscle mass and strength. *Co-premier auteur. The Journal of Physiology PMID:30614532

28. Faitg J, Leduc-Gaudet JP, Reynaud O, Ferland G, Gaudreau P, Gouspillou G. (2019) Effects of aging and caloric restriction on mitochondrial morphology and dynamics in rat oxidative and glycolytic muscles. Frontiers in Physiology PMID: 31114501

29. Moroz N, Maes K, Leduc-Gaudet JP, Goldberg P, Petrof BJ, Mayaki D. et al. (2019) Oxidant regulation of muscle proteolytic pathways in the diaphragm during prolonged mechanical ventilation. Anesthesiology PMID: 31408447

30. Leduc-Gaudet JP, Reynaud O, Chabot F, Mercier J, Andrich DE, St-Pierre DH, Gouspillou G. (2018) The impact of a short-term high-fat diet on mitochondrial respiration, reactive oxygen species production, and dynamics in oxidative and glycolytic skeletal muscles of young rats. Physiological Reports PMID: 29479852

31. St-Jean-Pelletier F, Pion CH, Leduc-Gaudet JP, Sgarioto N, Zovile I, Barbat-Artigas S, Reynaud O, Alkaterji F, Lemieux FC, Grenon A, Gaudreau P, Hepple RT, Chevalier S, Belanger M, Morais JA, Aubertin-Leheudre M, Gouspillou G. (2017) The impact of ageing, physical activity, and pre-frailty on skeletal muscle phenotype, mitochondrial content, and intramyocellular lipids in men. The Journal of Cachexia, Sarcopenia and Muscle PMID: 27897402

32. Stana F, Vujovic M, Mayaki D, Leduc-Gaudet JP, Leblanc P, Huck L, Hussain SNA. (2017) Differential Regulation of the Autophagy and Proteasome Pathways in Skeletal Muscles in Sepsis. Critical Care Medicine PMID: 28538438   

33. Leduc-Gaudet JP, Picard M, St-Jean Pelletier F, Sgarioto N, Auger MJ, Vallée J, Robitaille R, St-Pierre DH, Gouspillou G. (2015) Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice. Oncotarget PMID: 26053100

Complete list: https://pubmed.ncbi.nlm.nih.gov/?term=Leduc-Gaudet+JP&cauthor_id=28538438&size=50