Selected Publications

University of Chicago (Since 2020)

Fan, H.,* Xia, S.,* Xiang, J.,* Li, Y., Ross, M.O., Lim, S.A., Yang, F., Tu, J., Xie, L., Dougherty, U., Zhang, F.Q., Zheng, Z., Zhang, R., Wu, R., Dong, L., Su, R., Chen, X., Althaus, T., Riedell, P.A., Jonker, P.B., Muir, A., Lesinski, G.B., Rafiq, S., Dhodapkar, M.V., Stock, W., Odenike, O., Patel, A.A., Opferman, J., Tsuji, T., Matsuzaki, J., Shah, H., Faubert, B., Elf, S.E., Layden, B., Bissonnette, B.M., He, Y.-Y., Kline, J., Mao, H., Odunsi, K., Gao, X., Chi, H.,# He, C.,# and Chen, J. #  (2023) Trans-vaccenic acid reprograms CD8+ T cells and anti-tumor immunity. Nature (Available online 22 Nov 2023)

Gao, X. #, Liu, Y., Li, Y., Fan, H., Wu, R., Zhang, R., Faubert, B., He, Y.-Y.,  Bissonnette, M.B., Xia, S., Chen, D., Mao, H., Boggon, T.J., and Chen, J. # (2022) Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation.  Molecular Cell  82, 1992–2005 

Zhang, R.*, Chen, D.*, Fan, H., Wu, R., Tu, J., Zhang, F.Q., Wang, M., Zheng, H., Qu, C.-K., Elf, S.E., Faubert, B., He, Y.-Y.,  Bissonnette, M.B., Gao, X. #, DeBerardinis, R.J. #, and Chen, J. # (2022) Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells. Cell Chemical Biology 2022 Apr 13; S2451-9456(22)00127-1 

Chen, D.*, Xia, S.*, Zhang, R.*, Li, Y., Famulare, C.A., Fan, H., Wu, R., Wang, M., Zhu, A.C., Elf, S.E., Su, R., Dong, L., Arellano, M., Blum, W.G., Mao, H., Lonial, S., Stock, W., Odenike, O., Le Beau, M., Boggon, T.J.,  He, C., Chen, J.J., Gao, X.#, Levine, R.L.#, and Chen, J.#  (2021)  Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells.  Molecular Cell  2021 Sep 16;81(18):3833-3847.e11.   

Emory University (2004-2020)

Gao, X.*, Zhao, L.*, Liu, S.*, Li, Y., Xia, S., Chen, D., Wang, M., Wu, S., Dai, Q., Cai, F., Zacharias, L., DeBerardinis, R., Lim, E., Metallo, C., Boggon, T.J., Lonial, S., Lin, R., Mao, H., Pan, Y., Shang, C., and Chen, J. (2019) gamma-6-phosphogluconolactone, a byproduct of the oxidative pentose phosphate pathway, contributes to AMPK activation through inhibition of PP2A. Molecular Cell 76(6):857-871 e9 .  

Chen, D.*, Xia, S.*, Wang, M.*, Lin, R., Li, Y., Mao, H., Aguiar, M., Famulare, C., Shih, A.H., Brennan, C.W., Gao, X., Pan, Y., Liu, S., Fan, J., Jin, L., Song, L., Zhou, A., Mukherjee, M., Pieper, R.O., Mishra, A., Peng, J., Arellano, M., Blum, W., Lonial, S., Boggon, T.J., Levine, R.L.#, and Chen, J.# (2019) Mutant and wild-type IDH1 share enhancing mechanisms involving distinct tyrosine kinase cascades in cancer. Cancer Discovery DOI: 10.1158/2159-8290.CD-18-1040 Published June 2019  (Featured article).

Lin, R., Xia, S., Shan, C., Chen, D., Liu, Y., Gao, X., Wang, M., Kang, H.-B., Pan, Y., Liu, S., Chung, Y., Abdel-Wahab, O., Merghoub, T., Rossi, M., Kudchadkar, R.R., Lawson, D.H., Khuri, F.R., Lonial, S., and Chen, J. (2018) Dietary supplement chondroitin-4-sulfate exhibits oncogene-specific pro-tumor effects on BRAF V600E melanoma cells. Molecular Cell 69, 923–937, March 15, 2018 (Featured article).

Xia, S., Lin, R., Jin, L., Zhao, L., Kang, H.-B., Pan, Y., Liu, S., Qian, G., Qian, Z., Konstantakou, E., Zhang, B., Dong, J.-T., Chung, Y., Abdel-Wahab, O., Merghoub, T., Zhou, L., Kudchadkar, R.R., Lawson, D.H., Khoury, H.J., Khuri, F.R., Boise, L.H., Lonial, S., Lee, B.H., Pollack, B.P., Arbiser, J.L., Fan, J., Lei, Q.-Y., and Chen, J. (2017) Prevention of dietary fat-fueled ketogenesis attenuates BRAF V600E tumor growth. Cell Metabolism Volume 25, Issue 2, 7 February 2017, Pages 358–373.  Highlighted by Nature 

Fan, J.*, Lin, R.*, Xia, S., Chen, D., Elf, S.E., Liu, S., Pan, Y., Xu, H., Qian, Z., Wang, M., Shan, C., Zhou, L., Lei, Q.-Y., Li, Y., Mao, H., Lee, B.H., Sudderth, J., DeBerardinis, R. J., Zhang, G., Owonikoko, T., Gaddh, M., Arellano, M.L., Khoury, H.J., Khuri, F.R., Kang, S., Doetsch, P.W., Lonial, S., Boggon, T.J., Curran, W. J., and Chen, J. (2016) Tetrameric acetyl-CoA acetyltransferase 1 is important for tumor growth. Molecular Cell 2016 Dec 1;64(5):859-874. (Featured article).

Lin, R.*, Elf, S.*, Shan, C.*, Kang, H., Ji, Q., Zhou, L., Hitosugi, T., Zhang, L., Zhang, S., Seo, J.-H., Xie, J., Tucker, M., Gu, T.-L., Sudderth, J., Jiang, L., Mitsche, M., DeBerardinis, R., Wu, S., Li, Y., Mao, H., Chen, P., Wang, D., Chen, Z., Hurwitz, S., Lonial, S., Arellano, M., Khoury, H., Khuri, F., Lee, L., Lei, Q., Brat, D., Ye, K., Boggon, T., He, C., Kang, S., Fan, J.,and Chen, J. (2015) 6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling. Nature Cell Biology   2015 Nov;17(11):1484-96. doi: 10.1038/ncb3255. Epub 2015 Oct 19. 

Kang, H.-B.*, Fan, J.*, Lin, R.*,Elf, S., Ji, Q., Zhao, L., Jin, L., Seo, J.-H., Shan, C., Arbiser, J., Cohen, C., Brat, D., Miziorko, H., Kim, E., Abdel-Wahab O., Merghoub, T., Fröhling, S., Scholl, C., Tamayo, P., Barbie, D., Zhou, L., Pollack, B., Fisher, K., Kudchadkar, R., Lawson, D., Sica, G., Rossi, M., Lonial, S., Khoury, H., Khuri, F., Lee, B., Boggon, T., He, C., Kang, S., and Chen, J. (2015) Metabolic rewiring by oncogenic BRAF V600E links ketogenesis pathway to BRAF-MEK1 signaling. Molecular Cell  August 6, 2015, 59, 345–358  (Featured article highlighted by Nature Reviews Cancer, Cancer Discovery, and Molecular Cell)

Wang, J*, Luo, C*, Shan, C*, You, Q*, Lu, J, Elf, S., Zhou, Y., Wen, Y., Vinkenborg, J., Fan, J., Kang, H., Lin, R., Han, D., Xie, Y., Karpus, J., Chen, S., Ouyang, S., Luan, C., Zhang, N., Ding, H., Merkx, M., Liu, H., Chen, J.#, Jiang, H.#, He, C.# (2015) Inhibition of human copper trafficking by small molecule significantly attenuates cancer cell proliferation. Nature Chemistry 2015 Dec;7(12):968-79. doi: 10.1038/nchem.2381. Epub 2015 Nov 9. 

Shan C, Elf S, Ji Q,  Kang, H.-B., Zhou L, Hitosugi T, Jin L, Lin R, Zhang L, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, and Chen J. (2014) Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.  Molecular Cell 2014 Aug 21;55(4):552-65. doi: 10.1016/j.molcel.2014.06.020. Epub 2014 Jul 17.

Fan, J., Shan, C., Kang, H.-B., Elf, S., Xie, J., Tucker, M., Gu, T.-L., Aguiar, M., Lonning, S., Chen, H., Mohannadi, M., Britton, L.-M. P., Garcia, B.A., Aleckovic, M., Kang, Y., Kaluz, S., Devi, N., Van Meir, E., Hitosugi, T., Seo, J.H., Lonial, S., Gaddh, M., Arellano, M., Khoury, H.J., Khuri, F.R., Boggon, T.J., Kang, S., and Chen, J. (2014) Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex.  Molecular Cell 2014 Feb 20;53(4):534-48.

Hitosugi, T., Zhou, L., Fan, J., Elf, S., Zhang, L., Xie, J., Wang, Y., Gu, T.-L., Aleckovic, M., LeRoy, G., Kang, Y., Kang, H.-B., Seo, J.H., Shan, C., Jin, P., Gong, W., Lonial, S., Arellano, M., Khoury, H.J., Chen, G.Z., Shin, D.M., Khuri, F.R., Boggon, T.J., Kang, S., He, C., and Chen, J. (2013) Y26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation. Nature Communications 4, Article number:1790; doi:10.1038/ncomms2759

Hitosugi, T., Zhou, L., Elf, S., Fan, J., Kang, H., Seo, J., Shan, C., Dai, Q., Zhang, L., Xie, J., Gu, T.-L., Jin, P., Aleckovic, M., LeRoy, G., Kang, Y., Sudderth, J.A., DeBerardinis R.J., Luan, C., Chen, G.Z., Muller, S.M., Shin, D.M., Owonikoko, T.K., Lonial, S., Arellano, M., Khoury, H.J., Khuri, F.R., Lee, B.H., Ye, K., Boggon, T.J., Kang, S., He, C., and Chen, J. (2012) Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.  Cancer Cell November 13, 2012; 22(5): 585-600 (Featured article).

Hitosugi, T., Fan, J., Chung, T.W., Lythgoe, K., Wang, X., Xie, J., Ge, Q., Gu, T.-L., Polakiewicz, R.D., Roesel, J.L., Chen, Z., Boggon, T.J., Lonial, S., Khuri, F.R., Kang, S., and Chen, J. (2011) Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Molecular Cell 44 (6) 864-877. (Featured article).

Kang, S., Elf, S., Lythgoe, K., Hitosugi, T., Taunton, J., Zhou, W., Xiong, L., Wang, D., Muller, S., Fan, S., Sun, S.-Y., Marcus, A.I., Gu, T.-L., Polakiewicz, R.D., Chen, G.Z., Khuri, F.R., Shin, D.M., and Chen, J. (2010) RSK2 promotes head and neck cancer cell invasion and tumor metastasis. J Clin Invest 120(4):1165-77. 

Hitosugi, T., Kang, S., Chung, T.-W., Vander Heiden, M.G., Elf, S., Lythgoe, K., Dong, S., Lonial, S., Wang, X., Chen, G.Z., Xie, J., Gu, T.-L., Polakiewicz, R.D., Roesel, J.L., Boggon, T.J., Gilliland, D.G., Cantley, L.C., Kaufman, J., and Chen, J. (2009) Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.  Science Signaling 2009 Nov 17, 2(97) ra73 (Featured article).

Kang, S., Dong, S., Gu, T., Guo,A., Cohen, M.S., Lonial, S., Khoury, H.J., Fabbro, D., Gilliland, D. G., Bergsagel, P.L., Taunton, J., Polakiewicz, R.D., and Chen, J. (2007) FGFR3 activates RSK2 to mediate hematopoietic transformation through both tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.  Cancer Cell 12(3):201-14 (Featured article).