Metabolism Parameters

Metabolism Parameters

Figure 1 below shows the metabolism parameters of Aspirin

Cytochrome P450 (CYP) Isoforms

Importance: CYPs are a family of enzymes, primarily in the liver, responsible for metabolizing most drugs.

CYP Substrate: If a drug is a substrate for a specific CYP (e.g., CYP3A4), it means that the enzyme metabolizes it. This is normal, but co-administration with an inhibitor can affect drug levels.

CYP Inhibitor: If a drug is an inhibitor, it blocks the enzyme from metabolizing other drugs. This is a major cause of drug-drug interactions and is highly undesirable.

Desirable Range: Non-inhibitor for all major isoforms (CYP1A2, 2C9, 2C19, 2D6, 3A4).