NanoAssemblr® Ignite™

Quick and Easy to Use

The Ignite is simple to use and can be operated with little to no training. Formulations can be completed in under a minute and made on demand to quickly optimize experimental parameters.

Advance Novel Genetic Medicine Formulations

Genetic medicines have a wide design space that requires optimization to select a lead candidate. The Ignite is ideal for fine tuning process parameters and compositions for further scale up to the clinic.

Outstanding Reproducibility

Advanced microfluidics in an automated system removes batch-to-batch and user-to-user variability.

Scalable Technology

NxGen technology allows formulations to be rapidly scaled across the NanoAssemblr platform from 100 µL to 50 L.

Simple Workflow

Easy setup with touchscreen interface, saved recipes and a single-use fluid path enables a streamlined workflow.

RAPID

PRODUCTION

Over 50 formulations can be completed in a day for rapid optimization with each run taking less than one minute.

Versatile

Lipid, polymer or hybrid nanoparticles carrying small molecules, peptides or nucleic acids (and more) can be formulated on the Ignite.

Controller Assembly

Particle sizes can be tuned with precise control over fluid flow rates.

Scale Formulations with NxGen Technology Across the NanoAssemblr Platform

Using the same microfluidic geometry, formulations are scalable across the NanoAssemblr® platform greatly reducing process and formulation redevelopment when changing scales. Lipid nanoparticles containing nucleic acids maintain identical size and PDI when scaled across the platform.

Particle Size, polydispersity and hematocrit expression were consistent as production of mRNA-LNP was scaled using the NanoAssemblr platform.

Optimize Genetic Medicine Formulations

Rationally optimize your formulations by controlling process and chemical parameters like flow rate, concentration and charge. Quick formulation times allow for an efficient systematic approach to finding lead genetic medicine candidates.

Starting concentration, total flow rate and flow rate ratio parameters were varied, and 5 replicates were performed for each data point.

Enable Preclinical Experiments with Reproducible Formulations

Reproducibility across batches and users to enable critical preclinical experiments needed like small animal studies for genetic medicine development.

Particle size and encapsulation efficiency were performed in 4 replicates. Protein expression (Epo) experiments performed to show in vivo efficacy of mRNA-LNP.

Videos and Demonstrations

Accessories and Reagents

The Ignite has accessories and reagents available to expand the formulation capabilities and empower users to advance their genetic medicine.

Heating Package

The heating package empowers users to heat and keep their formulations in syringes at temperature when operating the Ignite.

GenVoy-ILM

GenVoy-ILM is an off-the-shelf, research use only reagent that lowers the barriers the genetic medicine development that can be used on the Ignite.

Cartridges

NanoAssemblr Ignite cartridges feature exclusive NxGen microfluidic technology that allows future scale up through a single mixer from ml/min to L/h.

Single Use Cartridges

No priming or cleaning required for an efficient workflow. Ignite cartridges are compatible with a wide range of solvents to make a diverse array of nanomedicine formulations.

Automatic Inline Dilution

Automated in-line dilution allows modelling of the processes that will be required for future GMP production of nanoparticles.

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