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Preclinical Testing Made Easy
Prior to clinical studies, safety and efficacy must be tested in multiple species. Use the NanoAssemblr Blaze to achieve:
SPEEDY AND EFFICIENT
SPEEDY AND EFFICIENT
Efficient formulation for large preclinical studies.
EASY SCALE-UP
EASY SCALE-UP
Easy scale-up of formulations developed on the NanoAssemblr® Ignite.
HIGH CAPACITY
HIGH CAPACITY
Greater formulation capacity with the simplicity and efficiency of the NanoAssemblr® Ignite.
VALIDATION OF INLINE DILUTION
VALIDATION OF INLINE DILUTION
Validation of Inline Dilution up to 5L, up to 50 L with Blaze+.
HIGH RANGE OF FORMULATION
HIGH RANGE OF FORMULATION
Formulation of 10 mL to 1L batches, up to 10 L with the Blaze+.
SCALABLE UPSTREAM AND DOWNSTREAM
SCALABLE UPSTREAM AND DOWNSTREAM
Scale-up development of upstream and downstream processes.
Accelerate Late Preclinical Development
Larger Volumes with
Blaze+ Upgrade
Up to 10 Liters per formulation
Connect bioprocess bags for closed system
Reduce cost by performing process development in house
Accelerate timelines by performing large scale formulations
Versatile Scalability
Using the same microfluidic geometry, formulations are scalable across the NanoAssemblr® platform. This greatly reduces process and formulation redevelopment when changing scales, compared to conventional batch-based methodologies. LNPs containing nucleic acids maintain identical size and PDI when scaled across the platform.
Particle Size, Polydispersity and RNA Encapsulation Efficiency were Consistent as Production of Epo-encoded mRNA-LNP was Scaled using the NanoAssemblr® Platform
Videos
Blaze Informational Presentation
Blaze Cartridges
NanoAssemblr® Blaze™ NxGen cartridges are the same as the cartridges on the GMP System, so parameters can be directly transferred between instruments to accommodate different scales of production. Cartridges are single-use and available with and without in-line dilution. Blaze cartridges are sold individually.
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