PRECISION Nanosystems

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NxGen Technology

The Evolution of Microfluidic Genetic Medicine Production

The proprietary NxGen microfluidic mixer at the heart of NanoAssemblr systems is designed specifically for genetic medicine development. Our Classic (formerly known as SHM) mixer was developed to address issues of reproducibility with scale-up achieved by scale-out of parallel mixers. NxGen, however, is uniquely capable of more than 25x throughput of our Classic mixer while maintaining the signature particle formation conditions that ensure the most reproducible results for a wide range of particle types.

The NxGen mixer enables the reproducible scale-up of mRNA Lipid Nanoparticles and other complex nanomedicine formulations

Test batches of up to 20 L/h produced with a single NxGen mixer
Particle characteristics (size and PDI) are constant
Biological activity maintained

NxGen Microfluidic Technology Powering Genetic Medicine

NxGen Mixer Manufactures Equivalent mRNA-LNP when Compared to the Classic Mixer

Mixer Flow Rate Size PDI mRNA

(mL/min) (nm) Encap. (%)

Classic 12 85 0.13 98

NXGen 200 90 0.10 98

Advanced Technology for Advanced Genetic Medicines

NxGen technology preserves non-turbulent mixing conditions to provide unparalleled control over nanoparticle assembly that is scalable from discovery to the clinic.

2.

An aqueous phase and a miscible Under laminar flow, the two phases

solvent containing dissolved do not immediately mix

nanoparticle precursors are

injected into each inlet of the

NanoAssemblr cartridge

3. 4.

Microscopic features engineered Rapid, controlled, homogenous

into the channel reproducibly mixing produces homogeneous

control the mixing of the two nanoparticles

streams

Precision NanoSystems' Technology

Precision NanoSystems - NanoAssemblr™ Platform

Accelerating the Development of Nanomedicines Microfluidics enables the manufacture of nanoparticles that would be difficult or even impossible to develop through an alternative method.

Molecular Teamwork

Millions of molecules contribute to a single nanoparticle. Both the chemical properties of these molecules and the physical properties of the particle (ex size and uniformity) affect performance. Carrier formulation depends on which active ingredients are used and the application.

Reproducible and Scalable Nanoparticle Research and Development

Using NanoAssmemblr® technology, develop a broad range of nanoparticle formulations, varying in size, payload and excipient characteristics. Find new designs for difficult-to-deliver drugs and hard-to-treat targets.