2025年
Asano H, Arai M, Narita A, Kuroiwa T, Fukuchi M, Yoshimoto Y, Oya S, Miyoshi G. Developmental regression of novel space preference in an autism spectrum disorder model is unlinked to GABAergic and social circuitry. Front Cell Neurosci. 2025, 18:1513347. PMID: -------
2024年
Matsuoka Y, Nakasone H, Kasahara R, Fukuchi M. Expression Profiles of Brain-Derived Neurotrophic Factor Splice Variants in the Hippocampus of Alzheimer's Disease Model Mouse. Biol Pharm Bull. 2024, 47(11):1858-1867. PMID: 39522980
Fukuchi M, Shibasaki Y, Akazawa Y, Suzuki-Masuyama H, Takeuchi KI, Iwazaki Y, Tabuchi A, Tsuda M. Neuron-selective and activity-dependent splicing of BDNF exon I-IX pre-mRNA. Neurochem Int. 2024, 181:105889. PMID: 39455010
Shimizu S, Nakano A, Ihara D, Nakayama H, Jo M, Toume K, Komatsu K, Shibahara N, Tsuda M, Fukuchi M, Tabuchi A. Panax notoginseng root extract induces nuclear translocation of CRTC1 and Bdnf mRNA expression in cortical neurons. Drug Discov Ther. 2024, 18(5):308-313. PMID: 39443121
Sakata K, Fukuchi M. Accelerated BDNF expression in visceral white adipose tissues following high-fat diet feeding in mice. Genes Cells. 2024, 29(11):1077-1084. PMID: 39278976
Ikegami R, Inoue T, Takamatsu Y, Nishio T, Fukuchi M, Haga S, Ozaki M, Maejima H. In vivo bioluminescence imaging revealed the change of the time window of BDNF expression in the brain elicited by a single bout of exercise following repeated exercise. Neurosci Lett. 2024, 834:137830. PMID: 38788795
2023年
Izumi H, Demura M, Imai A, Ogawa R, Fukuchi M, Okubo T, Tabata T, Mori H, Yoshida T. Developmental synapse pathology triggered by maternal exposure to the herbicide glufosinate ammonium. Front Mol Neurosci. 2023, 16:1298238. PMID: 3809894
Sakata K, Kobayashi T, Yokokura S, Fukuchi M. Early macrophage-mediated Bdnf expression in white adipose tissue during high-fat diet feeding. Biochem Biophys Res Commun. 2023, 686:149163. PMID: 37924667
Nakayama H, Ihara D, Fukuchi M, Toume K, Yuri C, Tsuda M, Shibahara N, Tabuchi A. The extract based on the Kampo formula daikenchuto (Da Jian Zhong Tang) induces Bdnf expression and has neurotrophic effects in cultured cortical neurons. J Nat Med. 2023, 77(3):584-595. PMID: 37148454
Ihara D, Miyata T, Fukuchi M, Tsuda M, Tabuchi A. SRF and SRF Cofactor mRNA Expression Is Differentially Regulated by BDNF Stimulation in Cortical Neurons. Biol Pharm Bull. 2023, 46(4):636-639. PMID: 36801840
Inoue T, Ikegami R, Takamatsu Y, Fukuchi M, Haga S, Ozaki M, Maejima H. Temporal dynamics of brain BDNF expression following a single bout of exercise: A bioluminescence imaging study. Neurosci Lett. 2023, 799:137120. PMID: 36764480
2022年
Fukuchi M, Mitazaki S, Saito-Moriya R, Kitada N, Maki SA, Izumi H, Mori H. Bioluminescence imaging using D-luciferin and its analogs for visualizing Bdnf expression in living mice; different patterns of bioluminescence signals using distinct luciferase substrates. J Biochem. 2022, 172(5):321-327. PMID: 36047849
2021年
Fukuchi M, Watanabe K, Mitazaki S, Fukuda M, Matsumoto S. Aminothioneine, a product derived from golden oyster mushrooms (Pleurotus cornucopiae var. citrinopileatus), activates Ca2+ signal-mediated brain-derived neurotrophic factor expression in cultured cortical neurons. Biochem Biophys Rep. 2021, 28:101185. PMID: 34977362
Komatsu H, Watanabe E, Fukuchi M. Psychiatric Neural Networks and Precision Therapeutics by Machine Learning. Biomedicines. 2021, 9(4):403. PMID: 33917863
Ishibashi Y, Shoji S, Ihara D, Kubo Y, Tanaka T, Tanabe H, Hakamata T, Miyata T, Satou N, Sakagami H, Mizuguchi M, Kikuchi K, Fukuchi M, Tsuda M, Takasaki I, Tabuchi A. Expression of SOLOIST/MRTFB i4, a novel neuronal isoform of the mouse serum response factor coactivator myocardin-related transcription factor-B, negatively regulates dendritic complexity in cortical neurons. J Neurochem. 2021, 159(4):762-777. PMID: 32639614
2020年
Fukuchi M, Saito R, Maki S, Hagiwara N, Nakajima Y, Mitazaki S, Izumi H, Mori H. Visualization of activity-regulated BDNF expression in the living mouse brain using non-invasive near-infrared bioluminescence imaging. Mol Brain. 2020, 13(1):122. PMID: 32894176
Mizukoshi M, Nozawa A, Oomizo S, Ihara D, Shiota J, Kikuchi K, Kaito M, Ishibashi Y, Ishikawa M, Fukuchi M, Tsuda M, Takasaki I, Tabuchi A. Differential localization and roles of splice variants of rat suppressor of cancer cell invasion (SCAI) in neuronal cells. Biochem Biophys Res Commun. 2020, 529(3):615-621. PMID: 32736682
Miyata T, Kikuchi K, Ihara D, Kaito M, Ishibashi Y, Hakamata T, Yamada T, Ishikawa M, Mizukoshi M, Shoji S, Fukuchi M, Tsuda M, Hida Y, Ohtsuka T, Kaneda M, Tabuchi A. Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain. Biochem Biophys Res Commun. 2020, 528(2):322-329. PMID: 32423795
Fukuchi M. Identifying inducers of BDNF gene expression from pharmacologically validated compounds; antipyretic drug dipyrone increases BDNF mRNA in neurons. Biochem Biophys Res Commun. 2020, 524(4):957-962. PMID: 32059848
2019年
Fukuchi M, Okuno Y, Nakayama H, Nakano A, Mori H, Mitazaki S, Nakano Y, Toume K, Jo M, Takasaki I, Watanabe K, Shibahara N, Komatsu K, Tabuchi A, Tsuda M. Screening inducers of neuronal BDNF gene transcription using primary cortical cell cultures from BDNF-luciferase transgenic mice. Sci Rep. 2019, 9(1):11833. PMID: 31413298
Komatsu H, Fukuchi M, Habata Y. Potential Utility of Biased GPCR Signaling for Treatment of Psychiatric Disorders. Int J Mol Sci. 2019, 20(13):3207. PMID: 31261897
Kikuchi K, Ihara D, Fukuchi M, Tanabe H, Ishibashi Y, Tsujii J, Tsuda M, Kaneda M, Sakagami H, Okuno H, Bito H, Yamazaki Y, Ishikawa M, Tabuchi A. Involvement of SRF coactivator MKL2 in BDNF-mediated activation of the synaptic activity-responsive element in the Arc gene. J Neurochem. 2019, 148(2):204-218. PMID: 30244496
2018年
Takasaki I, Watanabe A, Yokai M, Watanabe Y, Hayakawa D, Nagashima R, Fukuchi M, Okada T, Toyooka N, Miyata A, Gouda H, Kurihara T. In Silico Screening Identified Novel Small-molecule Antagonists of PAC1 Receptor. J Pharmacol Exp Ther. 2018, 365(1):1-8. PMID: 29363578
Kaneda M, Sakagami H, Hida Y, Ohtsuka T, Satou N, Ishibashi Y, Fukuchi M, Krysiak A, Ishikawa M, Ihara D, Kalita K, Tabuchi A. Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology. Sci Rep. 2018, 8(1):727. PMID: 29335431
2017年
Ihara D, Fukuchi M, Katakai M, Shinoda Y, Katoh-Semba R, Furuichi T, Ishikawa M, Tabuchi A, Tsuda M. Deltamethrin Increases Neurite Outgrowth in Cortical Neurons through Endogenous BDNF/TrkB Pathways. Cell Struct Funct. 2017, 42(2):141-148. PMID: 28943602
Fukuchi M. Studies of Neuronal Gene Regulation Controlling the Molecular Mechanisms Underlying Neural Plasticity. Yakugaku Zasshi. 2017, 137(9):1103-1115. PMID: 28867697
Kikuchi K, Shiota J, Yamada T, Ishikawa M, Ihara D, Fukuchi M, Tsuda M, Tabuchi A. Rho signaling inhibitor, CCG-1423, inhibits axonal elongation and dendritic complexity of rat cortical neurons. Biochem Biophys Res Commun. 2017, 492(3):474-479. PMID: 28830810
Fukuchi M, Izumi H, Mori H, Kiyama M, Otsuka S, Maki S, Maehata Y, Tabuchi A, Tsuda M. Visualizing changes in brain-derived neurotrophic factor (BDNF) expression using bioluminescence imaging in living mice. Sci Rep. 2017, 7(1):4949. PMID: 28694523
Fukuchi M, Sanabe T, Watanabe T, Kubota T, Tabuchi A, Tsuda M. Distinct regulation of activity-dependent transcription of immediate early genes in cultured rat cortical neurons. Biochem Biophys Res Commun. 2017, 490(3):682-687. PMID: 28634074
（以降は福地が富山大学所属時代の業績）
Fukuchi M, Tsuda M. Convergence of neurotransmissions at synapse on IEG regulation in nucleus. Front Biosci (Landmark Ed). 2017, 22(7):1052-1072. PMID: 28199192
Fukuchi M, Kuwana Y, Tabuchi A, Tsuda M. Balance between cAMP and Ca(2+) signals regulates expression levels of pituitary adenylate cyclase-activating polypeptide gene in neurons. Genes Cells. 2016, 21(8):921-929. PMID: 27383213
Fukuchi M, Kanesaki K, Takasaki I, Tabuchi A, Tsuda M. Convergent effects of Ca(2+) and cAMP signals on the expression of immediate early genes in neurons. Biochem Biophys Res Commun. 2015, 466(3):572-577. PMID: 26386156
Fukuchi M, Tabuchi A, Kuwana Y, Watanabe S, Inoue M, Takasaki I, Izumi H, Tanaka A, Inoue R, Mori H, Komatsu H, Takemori H, Okuno H, Bito H, Tsuda M. Neuromodulatory effect of Gαs- or Gαq-coupled G-protein-coupled receptor on NMDA receptor selectively activates the NMDA receptor/Ca2+/calcineurin/cAMP response element-binding protein-regulated transcriptional coactivator 1 pathway to effectively induce brain-derived neurotrophic factor expression in neurons. J Neurosci. 2015, 35(14):5606-5624. PMID: 25855176
Fukuchi M, Nakashima F, Tabuchi A, Shimotori M, Tatsumi S, Okuno H, Bito H, Tsuda M. Class I histone deacetylase-mediated repression of the proximal promoter of the activity-regulated cytoskeleton-associated protein gene regulates its response to brain-derived neurotrophic factor. J Biol Chem. 2015, 290(11):6825-6836. PMID: 25623071
Fukuchi M, Kirikoshi Y, Mori A, Eda R, Ihara D, Takasaki I, Tabuchi A, Tsuda M. Excitatory GABA induces BDNF transcription via CRTC1 and phosphorylated CREB-related pathways in immature cortical cells. J Neurochem. 2014, 131(2):134-146. PMID: 24965890
Ishikawa M, Shiota J, Ishibashi Y, Hakamata T, Shoji S, Fukuchi M, Tsuda M, Shirao T, Sekino Y, Baraban JM, Tabuchi A. Cellular localization and dendritic function of rat isoforms of the SRF coactivator MKL1 in cortical neurons. Neuroreport. 2014, 25(8):585-592. PMID: 24589521
Ishikawa M, Shiota J, Ishibashi Y, Hakamata T, Shoji S, Fukuchi M, Tsuda M, Shirao T, Sekino Y, Ohtsuka T, Baraban JM, Tabuchi A. Identification, expression and characterization of rat isoforms of the serum response factor (SRF) coactivator MKL1. FEBS Open Bio. 2013, 3:387-393. PMID: 24251100
Takasaki I, Oose K, Otaki Y, Ihara D, Fukuchi M, Tabuchi A, Tsuneki H, Tabuchi Y, Kondo T, Saitoh A, Yamada M, Tsuda M. Type II pyrethroid deltamethrin produces antidepressant-like effects in mice. Behav Brain Res. 2013, 257:182-188. PMID: 24079995
Xu G, Shen J, Ishii Y, Fukuchi M, Dang TC, Zheng Y, Hamashima T, Fujimori T, Tsuda M, Funa K, Sasahara M. Functional analysis of platelet-derived growth factor receptor-β in neural stem/progenitor cells. Neuroscience. 2013, 238:195-208. PMID: 23454370
Matsuya Y, Ihara D, Fukuchi M, Honma D, Itoh K, Tabuchi A, Nemoto H, Tsuda M. Synthesis and biological evaluation of pyrethroid insecticide-derivatives as a chemical inducer for Bdnf mRNA expression in neurons. Bioorg Med Chem. 2012, 20(8):2564-2571. PMID: 22429507
Ihara D, Fukuchi M, Honma D, Takasaki I, Ishikawa M, Tabuchi A, Tsuda M. Deltamethrin, a type II pyrethroid insecticide, has neurotrophic effects on neurons with continuous activation of the Bdnf promoter. Neuropharmacology. 2012, 62(2):1091-1098. PMID: 22079160
Fukuchi M, Fujii H, Takachi H, Ichinose H, Kuwana Y, Tabuchi A, Tsuda M. Activation of tyrosine hydroxylase (TH) gene transcription induced by brain-derived neurotrophic factor (BDNF) and its selective inhibition through Ca(2+) signals evoked via the N-methyl-D-aspartate (NMDA) receptor. Brain Res. 2010, 1366:18-26. PMID: 20965158
Fukuchi M, Tsuda M. Involvement of the 3'-untranslated region of the brain-derived neurotrophic factor gene in activity-dependent mRNA stabilization. J Neurochem. 2010, 115(5):1222-1233. PMID: 20874756
Dong YX, Fukuchi M, Inoue M, Takasaki I, Tabuchi A, Wu CF, Tsuda M. Pituitary adenylate cyclase-activating polypeptide (PACAP) is an upstream regulator of prodynorphin mRNA expression in neurons. Neurosci Lett. 2010, 484(3):174-177. PMID: 20728507
Ishikawa M, Nishijima N, Shiota J, Sakagami H, Tsuchida K, Mizukoshi M, Fukuchi M, Tsuda M, Tabuchi A. Involvement of the serum response factor coactivator megakaryoblastic leukemia (MKL) in the activin-regulated dendritic complexity of rat cortical neurons. J Biol Chem. 2010, 285(43):32734-32743. PMID: 20709749
Ishimaru N, Fukuchi M, Hirai A, Chiba Y, Tamura T, Takahashi N, Tabuchi A, Tsuda M, Shiraishi M. Differential epigenetic regulation of BDNF and NT-3 genes by trichostatin A and 5-aza-2'-deoxycytidine in Neuro-2a cells. Biochem Biophys Res Commun. 2010, 394(1):173-177. PMID: 20188708
Hara D, Miyashita T, Fukuchi M, Suzuki H, Azuma Y, Tabuchi A, Tsuda M. Persistent BDNF exon I-IX mRNA expression following the withdrawal of neuronal activity in neurons. Biochem Biophys Res Commun. 2009, 390(3):648-653. PMID: 19818730
Fukuchi M, Nii T, Ishimaru N, Minamino A, Hara D, Takasaki I, Tabuchi A, Tsuda M. Valproic acid induces up- or down-regulation of gene expression responsible for the neuronal excitation and inhibition in rat cortical neurons through its epigenetic actions. Neurosci Res. 2009, 65(1):35-43. PMID: 19463867
Hara D, Fukuchi M, Miyashita T, Tabuchi A, Takasaki I, Naruse Y, Mori N, Kondo T, Tsuda M. Remote control of activity-dependent BDNF gene promoter-I transcription mediated by REST/NRSF. Biochem Biophys Res Commun. 2009, 384(4):506-511. PMID: 19426709
Takasaki I, Takarada S, Tatsumi S, Azegami A, Yasuda M, Fukuchi M, Tabuchi A, Kondo T, Tabuchi Y, Tsuda M. Extracellular adenosine 5'-triphosphate elicits the expression of brain-derived neurotrophic factor exon IV mRNA in rat astrocytes. Glia. 2008, 56(13):1369-1379. PMID: 18649393
Yasuda M, Fukuchi M, Tabuchi A, Kawahara M, Tsuneki H, Azuma Y, Chiba Y, Tsuda M. Robust stimulation of TrkB induces delayed increases in BDNF and Arc mRNA expressions in cultured rat cortical neurons via distinct mechanisms. J Neurochem. 2007, 103(2):626-636. PMID: 17711418
Takasaki I, Takarada S, Fukuchi M, Yasuda M, Tsuda M, Tabuchi Y. Identification of genetic networks involved in the cell growth arrest and differentiation of a rat astrocyte cell line RCG-12. J Cell Biochem. 2007, 102(6):1472-1485. PMID: 17440958
Tsuda M, Hara D, Yasuda M, Fukuchi M, Tabuchi A. Role of activity-dependent gene expression of BDNF gene in synaptic plasticity. Seikagaku. 2006, 78(10):998-1007. PMID: 17131884
Fukuchi M, Tabuchi A, Tsuda M. Transcriptional regulation of neuronal genes and its effect on neural functions: cumulative mRNA expression of PACAP and BDNF genes controlled by calcium and cAMP signals in neurons. J Pharmacol Sci. 2005, 98(3):212-218. PMID: 16006741
Miyashita T, Tabuchi A, Fukuchi M, Hara D, Kisukeda T, Shimohata T, Tsuji S, Tsuda M. Interference with activity-dependent transcriptional activation of BDNF gene depending upon the expanded polyglutamines in neurons. Biochem Biophys Res Commun. 2005, 333(4):1241-1248. PMID: 15979572
Fukuchi M, Tabuchi A, Tsuda M. Activity-dependent transcriptional activation and mRNA stabilization for cumulative expression of pituitary adenylate cyclase-activating polypeptide mRNA controlled by calcium and cAMP signals in neurons. J Biol Chem. 2004, 279(46):47856-47865. PMID: 15355970
Fukuchi M, Sakuragawa S, Tabuchi A, Tsuda M. Calcium signal-mediated expression of the vasoactive intestinal polypeptide gene and its small contribution to activity-dependent survival of mouse cerebellar granule cells. J Neurosci Res. 2004, 77(1):26-34. PMID: 15197736
Tabuchi A, Ishii A, Fukuchi M, Kobayashi S, Suzuki T, Tsuda M. Activity-dependent increase in beta-amyloid precursor protein mRNA expression in neurons. Neuroreport. 2004 Jun 7;15(8):1329-1333.PMID: 15167560
Tabuchi A, Funaji K, Nakatsubo J, Fukuchi M, Tsuchiya T, Tsuda M. Inactivation of aconitase during the apoptosis of mouse cerebellar granule neurons induced by a deprivation of membrane depolarization. J Neurosci Res. 2003, 71(4):504-515. PMID: 12548706