Phytochemistry 

Phenolic Compounds of Justicia gendarussa Show Pharmacological Potentials Against Pain, Oxidation, Hyperglycemia, Diarrhea, and Microbes: Phyto-pharmacological and Computational Approaches

📅 Duration: January 2021 – Dec 2022
🏢 Affiliation: University of Dhaka
👨‍🔬 Supervisor: Dr. Aslam Hossain, Department of Pharmaceutical Chemistry, University of Dhaka 

📝 Project Synopsis:

During my master’s thesis, I investigated the pharmacological potential of the medicinal plant Justicia gendarussa. I isolated key secondary metabolites—beta-sitosterol, 1-monostearin, and lupeol—using chromatographic techniques and confirmed their structures through NMR. These compounds showed significant analgesic, hypoglycemic, antidiarrheal, antioxidant, and antimicrobial activities in both in vitro and in vivo (rodent model) experiments.

This experience deepened my interest in natural product-based drug discovery. I’m passionate about exploring nature-derived compounds as potential therapeutic agents and aim to pursue further research in this field, contributing to the development of safe and effective drugs from natural sources.

🧪 Skills Applied:

• Phytochemical Screening

• Column & Gel Permeation Chromatography

• Thin Layer Chromatography (TLC)

• Nuclear Magnetic Resonance (NMR) Spectroscopy

• Rodent Model Experimentation (Analgesic, Antidiarrheal, Hypoglycemic Assays)

• Antioxidant & Antimicrobial Assays

• Scientific Data Analysis (SPSS)

• Computational Binding Affinity Analysis

• Scientific Writing and Literature Review

📚Publication : Published in BioMed Research International (Q2), a peer-reviewed journal in the biomedical sciences.