PUBLICATIONS (2017~present)
2024
Jeong JW, Kim H, Kim M, Jo S, Lee HK, Kim HJ, Park JS*, Kim H*, Fang S* (2024) Proteasomal deubiquitinases USP14 and UCHL5 regulate ERRα transcriptional activity to control mitochondrial OXPHOS in pancreatic cancer cells (in preparation) (1st Author: Jae Woong Jeong) (*Corresponding Author)
Jeon H, Lee YS, Shim S, Hwang N, Kim TH, Kim MY, Joo S, Kim JW*, Kim DK*, Fang S* (2024) FXR-Reg3g axis reduces adipose inflammation to restore glucose homeostasis (in preparation) (1st Author: Hyeonuk Jeon & Yo Seob Lee) (*Corresponding Author)
Jeong JW, Lee J, Lee CM, Hwang Y, Fang S, Lee HK*, Ahn SG* (2024) PR inhibition stimulates G6PD expression to enhance malignancy in luminal A type breast cancer (in preparation) (1st Author: Jae Woong Jeong)
Hwang Y, Lee CM, Park YC, Jeong JW, Jo S, Joo S, Kim H, Kim M, Lee HK, Shin SJ*, Park EJ*, Bhin J*, Fang S* (2024) PHGDH promotes immunosuppressive molecular signatures of inflammatory cancer-associated fibroblasts to drive Epithelial-Mesenchymal Transition in colorectal cancer (in preparation) (1st Author: Yeseong Hwang, Chae Min Lee, & Ye-Chan Park) (*Corresponding Author)
Hwang N, Kang D, Park EJ, Kim M, Hwang Y, Kim JW, Shin SJ*, Chun J*, Yoon BK*, Fang S* (2024) A comprehensive single-cell spatial transcriptomic analysis of ulcerative colitis and colorectal cancer (in preparation) (1st Author: Nahee Hwang & Dongwoo Kang) (*Corresponding Author)
Lee EK, Hwang N, Kim Y, Kim Y, Kang YW, Kim JW, Fang S, Oh CM (2024) A comprehensive single-cell spatial transcriptomic analysis of midbrain pathology in a murine model of Parkinson's disease (in preparation) (1st Author: Nahee Hwang)
Joo S, Hwang Y, Jeon H, Jeong JW, Lee CM, Bhin J*, Lee YH*, Fang S* (2024) Monocyte-derived kupffer cells (MoKCs) exhibit lysosomal stress responses in nonalcoholic steatohepatitis (in preparation) (1st Author: Seyeon Joo & Yeseong Hwang) (*Corresponding Author)
Chun KH, Yoon BK, Hwang N, Lee Y, Kim JW, Jeon H, Cheong JH*, Fang S*, Kim JW* (2024) RASD1 suppresses GM-CSF signaling network to confer immunosuppressive tumor microenvironment (in preparation) (1st Author: Kyu Hye Chun & Bo Kyung Yoon) (*Corresponding Author)
Jeon H, Lee S, Lee Y, Kim M, Hwang N, Oh CM*, Fang S* (2024) Voluntary exercise protects against aging-induced intestinal dysfunction (in preparation) (1st Author: Hyeonuk Jeon & Siyeon Lee) (*Corresponding Author)
Jo S, Ok T, Kim M, Hwang N, Lee K*, Fang S*, Yoon BK* (2024) Spatial transcriptomic analysis of immune profile from blood clots (in preparation) (1st Author: Sugyeong Jo) (*Corresponding Author)
Kim M, Joo S, Kim H, Jeong JW, Hwang Y, Lee CM, Lee HK, Park EJ*, Kim H*, Fang S* (2024) FXR drives mitochondrial one carbon pathway to maintain redox balance in colorectal cancer (in preparation) (1st Author: Minki Kim & Seyeon Joo) (*Corresponding Author)
Joo S, Je Y, Bae Y, Yoon BK, Shin SJ*, Fang S*, Kim JH* (2024) One carbon pathway is crucial for CD44-positive instestinal subtype gastric cancer (in preparation) (1st Author: Seyeon Joo) (*Corresponding Author)
Lee CM, Kim AS, Park YC, Hwang N, Kim M*, Fang S* (2024) T cell-mediated inflammatory crosstalk of lung microenvironment in Chronic Obstructive Pulmonary Disease (in preparation) (1st Author: Chae Min Lee) (*Corresponding Author)
Park YC, Hwang Y, Jeong JW, Lee CM, Kim M, Jo S, Joo S, Hwang N*, Fang S* (2024) One-carbon metabolism controls Notch signaling in CD4+ bystander T cell to enhance immunotherapy response in lung adenocarcinoma (in preparation) (1st Author: Ye-Chan Park & Yeseong Hwang) (*Corresponding Author)
Lee CM, Kim AS, Jeong JW, Kim M, Jo S, Fang S* (2024) Dynamics of T cell-mediated immune signaling network during pathogenesis of chronic obstructive pulmonary disease (submitted) (1st Author: Chae Min Lee & Andrew Kim) (*Corresponding Author)
Yoon BK, Bae Y, Je Y, Shin SJ, Joo S, Jung CM, Fang S, Kim JH* (2024) Patient-derived organoids from multiple sites of the single tumor recapitulates intratumoral heterogeneity in gastric cancer. (submitted) (1st Author: Bo Kyung Yoon)
Lee CM, Hwang Y, Kim M, Kim H, Fang S* (2024) PHGDH: A novel therapeutic target in cancer. Experimental & Molecular Medicine (in press) (1st Author: Chae Min Lee) (*Corresponding Author)
Lee Y, Kim M, Joo S, Hwang Y, Fang S*, Kim JW* (2024) DGAT2 plays a crucial role to control ESRRA-PROX1 transcriptional network to maintain hepatic mitochondrial sustainability. Diabetes and Metabolism Journal (in press) (1st Author: Yoseob Lee) (*Corresponding Author) (link)
Joo S, Fang S* (2024) Bile Acids and Gastric Intestinal Metaplasia: Exploring a New Feedback Loop. Gut and Liver 18(3):365-367 (1st Author: Seyeon Joo) (*Corresponding Author) (link)
Joo S, Lee SY, Lee SY, Hwang Y, Kim M, Jeong JW, Jang SI*, Fang S* (2024) Triamcinolone acetonide alleviates benign biliary stricture by ameliorating biliary fibrosis and inflammation. BMB Reports 57(4):200-205 (1st Author: Seyeon Joo) (*Corresponding Author) (link)
Lee CM, Hwang Y, Lee J, Jeon H, Jeong JW, Joo S, Lee HK, Ahn SG*, Fang S* (2024) BRCA1 mutation promotes sprouting angiogenesis in inflammatory cancer-associated fibroblasts of Triple-negative breast cancer. Cell Death Discovery 10:5 (1st Author: Chae Min Lee & Yeseong Hwang) (*Corresponding Author) (link) (CDD press: Monthly Reader's Choice)
2023
Lee CM, Fang S* (2023) Fat Biology in TNBC: Immune Regulation, Fibrosis, and Senescence. Journal of Obesity & Metabolic Syndrome 32(4):312-321 (1st Author: Chae Min Lee) (*Corresponding Author) (link)
Hwang N, Kang D, Shin SJ, Yoon BK, Chun J*, Kim JW*, Fang S* (2023) Creeping fat exhibits distinct inflammation-specific adipogenic preadipocytes in Crohn's disease. Frontiers in Immunology 14:1198905 (1st Author: Nahee Hwang & Dongwoo Kang) (*Corresponding Author) (link)
Kang HW, Kim JH, Lee DE, Lee YS, Kim HS, Fang S, Lee BE, Lee KJ, Yoo J, Kim HJ, Park JS (2023) Combination therapy of niclosamide with gemcitabine inhibited cell proliferation and apoptosis via Wnt/β -catenin/c-Myc signaling pathway by inducing β -catenin ubiquitination in pancreatic cancer. Cancer Biology & Therapy 24(1):2272334 (link)
Hwang N, Yoon BK, Chun KH, Kim H, Lee Y, Kim JW, Jeon H, Fang S*, Cheong JH*, Kim JW* (2023) Caveolin-1 enables aggressive gastric cancer to utilize extracellular proteins for survival. Experimental & Molecular Medicine 55(11):2461-2472 (1st Author: Nahee Hwang & Bo Kyung Yoon) (*Corresponding Author) (link)
Chun KH, Park YC, Hwang N, Yoon BK, Kim JW*, Fang S* (2023) Gene signature from cutaneous autoimmune diseases provides potential immunotherapy-relevant biomarkers in melanoma. Scientific Reports 13(1):15023 (1st Author: Kyu Hye Chun & Ye-Chan Park) (*Corresponding Author) (link)
Hong WC, Lee DE, Kang HW, Kim MJ, Kim M, Kim JH, Fang S, Kim HJ, Park JS (2023) CD74 promotes a pro-inflammatory tumor microenvironment by inducing S100A8 and S100A9 secretion in pancreatic cancer. International Journal of Molecular Sciences 24(16):12993 (link)
Hwang Y, Yun HJ, Jeong JW, Kim M, Joo S, Lee HK, Chang HS, Kim SM*, Fang S* (2023) Co-inhibition of glutaminolysis and one carbon metabolism promotes ROS accumulation leading to enhancement of chemotherapeutic efficacy in anaplastic thyroid cancer. Cell Death and Disease 14(8):515 (1st Author: Yeseong Hwang) (*Corresponding Author) (link)
Kim S, Song YK, Cho CS, Kim HJ, Fang S, Jo DH, Kim H* (2023) Inhibition of protein arginine deiminase II suppresses retinoblastoma in orthotopic transplantation in mice. Oncology Reports 50(1):146 (link)
Kim H, Ahn HS, Hwang N, Huh Y, Bu S, Seo KJ, Kwon SH, Lee HK, Kim JW, Yoon BK*, Fang S* (2023) Epigenomic landscape exhibits interferon signaling suppression in the patient of myocarditis after BNT162b2 vaccination. Scientific Reports 13(1):8926 (1st Author: Hyeonhui Kim) (*Corresponding Author) (link)
Yoon BK, Kim H, Oh TG, Oh SK, Jo S, Kim M, Chun KH, Hwang N, Lee S, Jin S, Atkins AR, Yu RT, Downes M, Kim JW*, Kim H*, Evans RM*, Cheong JH*, Fang S* (2023) PHGDH preserves one-carbon cycle to confer metabolic plasticity in chemo-resistant gastric cancer during nutrient stress. Proceedings of the National Academy of Sciences USA 120(21):e2217826120 (1st Author: Bo Kyung Yoon & Hyeonhui Kim) (*Corresponding Author) (link)
Jeon J, Lee D, Kim B, Park BY, Oh CJ, Kim MJ, Jeon JH, Lee IK, Park O, Baek S, Lim CW, Ryu D, Fang S, Auwerx J, Kim KT, Jung HY (2023) CycloZ improves hyperglycemia and lipid metabolism by modulating lysine acetylation in KK-Ay mice. Diabetes and Metabolism Journal 47(5):653-667 (link)
Park KC, Kim JM, Kim SY, Kim SM, Lim JH, Kim MK, Fang S, Kim Y, Mills GB, Noh SH, Cheong JH (2023) PMCA inhibition reverses drug resistance in clinically refractory cancer patient-derived models. BMC Medicine 21(1):38 (link)
2022
Kim G, Yoon Y, Park JH, Park JW, Noh MG, Kim H, Park C, Kwon H, Park JH, Kim Y, Sohn J, Park S, Kim H, Im SK, Kim Y, Chung HY, Nam MH, Kwon JY, Kim IY, Kim YJ, Baek JH, Kim HS, Weinstock GM, Cho B, Lee C, Fang S*, Park H*, Seong JK* (2022) Bifidobacterial carbohydrate/nucleoside metabolism enhances oxidative phosphorylation in white adipose tissue to protect against diet-induced obesity. Microbiome 10:188 (*Corresponding Author) (link)
Park SE, Lee D, Jeong JW, Lee SH, Park SJ, Ryu J, Oh SK, Yang H*, Fang S*, Kim S* (2022) Gut epithelial inositol polyphosphate multikinase alleviates experimental colitis via governing tuft cell homeostasis. Cellular and Molecular Gastroenterology and Hepatology 14(6):1235-1256 (*Corresponding Author) (link)
Yoon BK, Oh TG, Bu S, Seo KJ, Kwon SH, Lee JY, Kim Y, Kim JW, Ahn HS*, Fang S* (2022) The peripheral immune landscape in a patient with myocarditis after the administration of BNT162b2 mRNA vaccine. Molecules and Cells 45(10):738-748 (1st Author: Bo Kyung Yoon) (*Corresponding Author) (link)
Hwang N, Huh Y, Bu S, Seo KJ, Kwon SH, Kim JW, Yoon BK*, Ahn HS*, Fang S* (2022) Single-cell sequencing characterizes the altered transcriptomic landscape of classical monocytes in BNT162b-induced myocarditis. Frontiers in Immunology 13:979188 (1st Author: Nahee Hwang & Yune Huh) (*Corresponding Author) (link)
Lee DE, Kang HW, Kim SY, Kim MJ, Jeong JW, Hong WC, Fang S, Kim HS, Lee YS, Kim HJ, Park JS (2022) Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction. Frontiers in Pharmacology 13:934746 (link)
Shim S, Krishnaiah M, Sankham MR, Kim I, Lee Y, Shin I, Oh AR, Lee HJ, Vu T, Park J, Choi S, Park S, Kwon Y, Fang S*, Kim DK* (2022) Discovery of (E)-3-(3-((2-Cyano-4'-dimethylaminobiphenyl-4-ylmethyl)cyclohexanecarbonylamino)-5-fluorophenyl)acrylic Acid Methyl Ester, an Intestine-specific, FXR Partial Agonist for the Treatment of Nonalcoholic Steatohepatitis. Journal of Medicinal Chemistry 65(14):9974-10000 (*Corresponding Author) (link)
Jang SI*, Fang S*, Nahm JH, Cho JH, Do MY, Lee SY, Jeong S, Lee DH, Lee DK (2022) Preclinical evalutation of endoscopic placement of a steroid-eluting metal stent in an in vivo porcine benign biliary stricture model. Scientific Reports 12(1):8864 (*1st Author) (link)
Yun HJ, Kim M, Kim SY, Fang S, Kim Y, Chang HS, Chang HJ, Park KC (2022) Effects of anti-cancer drug sensitivity-related genetic differences of therapeutic approaches in refractory papillary thyroid cancer. International Journal of Molecular Sciences 23(2):699 (1st Author: Min Ki Kim) (link)
2021
Jo S and Fang S* (2021) Therapeutic strategies for diabetes: Immune modulation in pancreatic β cells. Frontiers in Endocrinology 12(716692):1~12 (1st Author: Sugyeong Jo) (*Corresponding Author) (link)
Yoon BK, Hwang N, Chun KH, Lee Y, Duarte TPM, Kim JW, Kim TH, Cheong JH, Fang S*, Kim JW* (2021) Sp1-induced FNBP1 drives rigorous 3D cell motility in EMT-type gastric cancer cells. International Journal of Molecular Sciences 22(13):6784 (1st Author: Bo Kyung Yoon) (*Corresponding Author) (link)
Yoon Y, Kim G, Jeon BN, Fang S, Park H (2021) Bifidobacterium strain-specific enhances the efficacy of cancer therapeutics in tumor-bearing mice. Cancers 13(5):957 (link)
2020
Yoon Y, Kim G, Noh M, Park J, Jang M, Fang S*, Park H* (2020) Lactobacillus fermentum promotes adipose tissue oxidative phosphorylation to protect against diet-induced obesity. Experimental and Molecular Medicine 52(9):1574-1586 (*Corresponding Author) (link)
Jeong JW, Kim M, Lee J, Lee HK, Ko Y, Kim H*, Fang S* (2020) ID1-mediated BMP signaling pathway potentiates Glucagon-like peptide-1 secretion in response to nutrient replenishment. International Journal of Molecular Sciences 21(11):E3824 (1st Author: Jae Woong Jeong) (*Corresponding Author) (link)
Seok JW, Kim D, Yoon BK, Lee Y, Kim HJ, Hwang N, Fang S, Kim HJ, Kim JW (2020) Dexras1 plays a pivotal role in maintaining the equilibrium between adipogenesis and osteogenesis. Metabolism 108:154250 (link)
Kim HJ, Lee Y, Fang S, Kim W, Kim HJ, Kim JW (2020) GPx7 ameliorates non-alcoholic steatohepatitis by regulating oxidative stress. BMB Reports 53(6):317-322 (link)
Jang SI*, Fang S*, Baek YY, Lee DH, Na K, Lee SY, Lee DK (2020) Local delivery of Gemcitabine inhibits pancreatic and cholangiocarcinoma tumor growth by promiting epidermal growth factor receptor degradation. International Journal of Molecular Sciences 21(5):1605 (*1st Author) (link)
2019
Kim J, Ahn CW, Fang S, Lee HS, Park JS (2019) Association between metformin dose and vitamin B12 deficiency in patients with type 2 diabetes. Medicine 98(46):e17918 (link)
Oh SK, Kim D, Kim K, Boo K, Yu YS, Kim IS, Jeon Y, Im SK, Lee SH, Lee JM, Ko Y, Lee H, Park D*, Fang S*, Baek SH* (2019) RORα is crucial for attenuated inflammatory response to maintain intestinal homeostasis. Proceedings of the National Academy of Sciences USA 116(42):21140-21149 (*Corresponding Author) (link)
Jang SI*, Fang S*, Kim KP, Ko Y, Kim H, Oh J, Hong GY, Lee SY, Kim JM, Noh I, Lee DK (2019) Combination treatment with n-3 polyunsaturated fatty acids and ursodeoxycholic acid dissolves cholesterol gallstones in mice. Scientific Reports 9(12740):1-13 (*1st Author) (link)
Fu T, Coulter S, Yoshihara E, Oh TG, Fang S, Cayabyab F, Zhu Q, Zhang T, Leblanc M, Liu S, He M, Waizenegger W, Gasser E, Schnabl B, Atkins AR, Yu RT, Knight R, Liddle C, Downes M, Evans RM (2019) FXR regulates intestinal cancer stem cell proliferation. Cell 176(5):1098-1112 (link)
Kim KS, Jang MJ, Fang S, Yoon SG, Kim IY, Seong JK, Yang HI, Hahm DH (2019) Anti-obesity effect of taurine through inhibition of adipogenesis in white fat tissue but not in brown fat tissue in a high-fat diet-induced obese mouse model. Amino Acids 51(1):245-254 (link)
2018
Kim H, Kim M, Im SK*, Fang S* (2018) Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes. Lab Anim Res 34(4):147-159 (1st Author: Hyeonhui Kim) (*Corresponding Author) (link)
Kim H, Fang S* (2018) Crosstalk between FXR and TGR5 controls glucagon-like peptide 1 secretion to maintain glycemic homeostasis. Lab Anim Res 34(4):140-146 (1st Author: Hyeonhui Kim) (*Corresponding Author) (link)
Hong SH, Fang S, Lu BC, Nofsinger R, Kawakami Y, Castro GL, Yin Y, Lin C, Yu RT, Downes M, Izpisúa Belmonte JC, Shilatifard A, Evans RM (2018) Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis. Proceedings of the National Academy of Sciences USA 115(41): 10381-10386 (link)
Wei Z, Yoshihara E, He N, Hah N, Fan W, Pinto A, Huddy T, Wang Y, Ross B, Estepa G, Dai Y, Ding N, Sherman M, Fang S, Zhao X, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM (2018) Vitamin D switches BAF complexes to protect β cells. Cell 173(5):1135-1149 (link)
2017
Kim K, Lee JM, Yu YS, Kim H, Nam HJ, Moon HG, Noh DY, Kim KI, Fang S, Baek SH (2017) RORα2 requires LSD1 to enhance tumor progression in breast cancer. Scientific Reports 7(11994): 1~11 (link)
Kim K, Boo K, Yu YS, Oh SK, Kim H, Jeon Y, Bhin J, Hwang D, Kim KI, Lee JS, Im SS, Yoon SG, Kim Y, Seong JK, Lee H, Fang S*, and Baek SH* (2017) RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network. Nature Communications 8(1):162 (*Corresponding Author) (link)
Fang S* (2017) Bile acid receptor Farnesoid X Receptor: A novel therapeutic target for metabolic diseases. Journal of lipid and Atherosclerosis 6(1):1-7 (*Corresponding Author) (link)