PUBLICATIONS (2003~2016)

2016

15) Kim SG, Kim BK, Kim K, Fang S (2016) Bile Acid Nuclear Receptor Farnesoid X Receptor: Therapeutic Target for Nonalcoholic Fatty Liver Disease. Endocrinol Metab 31(4):500-504 (link)

14) Yoshihara E, Wei Z, Lin CS, Fang S, Ahmadian M, Kida Y, Tseng T, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM (2016) ERRγ is required for the metabolic maturation of therapeutically functional glucose-responsive β cells. Cell Metabolism 23(4):622~634 (link)

2015

13) Bapat SP, Suh JM, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, Leblanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM, Zheng Y (2015) Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature 528(7580):137~141 (link)

12) Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Jacinto S, Lukasheva Y, Atkins A, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M and Evans RM (2015) Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nature Medicine 21(2):159~165 (link)

11) Kim YC, Fang S, Byun S, Seok S, Kemper B and Kemper JK (2015) FXR-induced lysine-specific demethylase, LSD1, reduces hepatic bile acid levels and protects the liver against bile acid toxicity. Hepatology 62(1): 220~31 (link)

2013

10) Fang S and Evans RM. (2013) Wealth management in the gut. Nature 500:538~539 (link)

2011

9) Fang S, Suh JM, Atkins AR, Hong S, Leblanc M, Nofsinger RR, Yu RT, Downes M and Evans RM (2011) Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance. Proc Natl Acad Sci USA 108(8):3412~7  (link)

8) Kanamaluru D, Xiao Z, Fang S, Choi SE, Kim DH, Veenstra TD and Kemper JK (2011) Arginine methylation by PRMT5 at a naturally-occuring mutation site is critical for liver metabolic regulation by Small Heterodimer Partner. Mol Cell Biol 31(7):1540~50 (link)

2009

7) Kemper JK, Xiao Z, Ponugoti B, Miao J, Fang S, Kanamaluru D, Tsang S, Wu SY, Chiang CM, and Veenstra TD (2009) FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. Cell Metabolism 4;10(5):392~404 (link)

6) Miao J, Fang S, Lee J, Comstock C, Knudsen SE and Kemper JK (2009) Functional specificity of Brm and Brg-1 Swi/SnfATPases in the feedback regulation of hepatic bile acid biosynthesis. Mol Cell Biol 29(23):6170~81 (link)

2008

5) Fang S, Tsang S, Jones R, Ponugoti B, Yoon H, Wu S, Chiang M, Willson T, and Kemper JK (2008) The p300 acetylase is critical for ligand-activated FXR induction of SHP. J Biol Chem 283:35086~95  (link)

2007

4) Ponugoti B, Fang S and Kemper JK (2007) Functional interaction of Hepatic Nuclear Factor-4 and Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α in CYP7A1 regulation is inhibited by a key lipogenic activator, Sterol Regulatory Element-Binding Protein-1c.  Mol Endocrinology 21(11):2698~2712 (link)

3) Fang S, Miao J, Xiang L, Ponugoti B, Treuter E and Kemper JK (2007) Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism. Mol Cell Biol 27(4):1407~24  (1st Author) (link)

2006

2) Miao J, Fang S, Bae Y and Kemper JK (2006) Functional inhibitory cross-talk between CAR and HNF-4 in hepatic lipid/glucose metabolism is mediated by competition for the binding to DR1 motif and to the common coactivators, GRIP-1 and PGC-1α. J Biol Chem 281(21):14537~46 (link)

2004

1) Bhalla S, Ozalp C, Fang S, Xiang L and Kemper JK (2004) Ligand-activated PXR interferes with HNF-4 signaling by targeting a common coactivator PGC-1α: Functional implication in hepatic cholesterol and glucose metabolism. J Biol Chem 279:45139~47 (link)