Hormones are molecules that are delivered to tissues throughout the body by the blood, and bind to receptor sites on target cells. They work to regulate and coordinate various bodily functions
Hormones function to regulate growth, development, and metabolism, maintain homeostasis of blood composition and volume, control digestive processes, and control reproductive activities
Goal of hormones is to change gene transcription, which changes the amount of protein that you are making. Mechanisms of hormone action include changing permeability of the cell membrane, synthesis of new molecules, altering rate of metabolic action, and stimulating transport of a substance into and out of the cell
Released by Endocrine glands. Ex: Pituitary gland, adrenal glands
Travels through the blood
Acts on specific target cells, organs, and tissues
Example: Hormone secretion
Released by exocrine glands. Ex: Sebaceous glands, sweat glands
Travels through ducts
Acts on body cavities, lumens of the organs, and surface of the body
Example: Secretion of sweat from sweat glands
Steroid hormones diffuse through the cell membrane, bind to intracellular receptors, and then change gene transcription. Slower process, longer lasting effects. Ex: Estrogen, testosterone.
Peptide hormones bind to cell membrane receptor, trigger second messengers, then change intracellular signaling. Faster response, effects are short lived. Ex: Insulin, ADH
Half-Life is the time required for a substance in the body to decrease in concentration by 50%. Determines how long the effects last, dosing frequency, and timing for lab tests
Clinical Correlations
Why is ADH important for regulating hydration and blood pressure?
ADH is released in response to dehydration or low blood volume. It forces the kidneys to reabsorb more water in order to decrease fluid loss in the urine. This makes sure the body stays hydrated and increased water retention boosts blood volume and blood pressure. ADH also constricts blood vessels which boosts blood pressure.
What symptoms might occur with low thyroid hormone (T₃/T₄) or high cortisol levels?
Fatigue, weight gain, muscle weakness, brain fog, and mood issues.
How does the nurse monitor endocrine function through lab values (e.g., TSH, cortisol, glucose)?
Monitoring endocrine function through lab values allows us to assess hormone function. This is often done by drawing blood in which we can see what amount of hormone is being produced by the body. We have set ranges for the hormone so we can assess whether we are making too much or too little of the hormone.
How do hormonal changes influence metabolism, growth, and reproductive health?
Through chemical signals released by endocrine organs which travel through the blood and act on target cells, tissues, and organs.
Why might a nurse assess for fluid balance and urine output in a patient with ADH issues?
To monitor water retention or for excessive water loss. This can affect body hydration status, blood pressure, electrolyte balance, etc., causing various problems throughout the body if ADH is not monitored correctly.
Reflection
Which three hormones are most clinically relevant to healthcare professionals? Why?
Thyroid hormones due to the fact that regulates the body’s metabolism, temperature, and energy use. It is essential to monitoring overall health and can cause a wide array of symptoms if thyroid hormone production has issues.
Insulin due to the fact that it controls blood glucose levels. If not monitored can cause uncontrolled diabetes mellitus which can cause many complications throughout the body. Most common issues include neuropathy symptoms and gastrointestinal issues
Cortisol due to the fact that it helps the body respond to stress, regulates blood pressure, and is involved in immune response. Uncontrolled cortisol levels can lead to long-term health issues such as cardiovascular issues, and a slower immune response.
How can understanding the endocrine feedback system improve your ability to assess patient symptoms?
Endocrine feedback systems are vital to maintaining homeostasis throughout the body, so understanding what each hormone does allows us to study and identify the clinical symptoms that can manifest in patients who are having hormone production issues, in turn allowing us to treat the patient effectively.
What was the most surprising or complex concept you learned about hormone control?
The most surprising concept that I learned about hormone control is the fact that hormones change gene transcription which then changes protein production, adjusting the body function. I never thought about hormones being able to alter the body on a genetic level, however it makes sense for our body to be able to change and grow that it would need to do so.