PUBLICATIONS

Research Papers  (*Corresponding author, # Equal contribution, People from the lab) 

1. Chang C-H*, de la Cruz AF, Lai H-Y, Natividad IM, Noyola A, Abellanosa AM E, Lee N, Malik HS (2025) Rapid protamine evolution suppresses meiotic drive in Drosophila. bioRxiv:10.1101/2025.09.03.674087.

2. Chang C-H#*, Handler T#, Fuda N, Pascua D, Mouton T, Larracuente AM* (2026) Pervasive suppressors halt the spread of selfish Segregation Distorter in a natural population. Genetics, 2026;, iyag108

3. Soares RF, Chang C-H, Koerich, LB, Malik HS, Kuhn GCS* (2025) Retention of a single Cenp-C gene in different syntenic locations in the montium group of Drosophila species. bioRxiv: 10.64898/2025.12.11.693522

4. Edvalson LT#, Wei X#, Chang C-H, Larracuente AM* (2025) Disruption of small RNAs and mechanistic variation in Segregation Distorter—a sperm-killing drive system in Drosophila melanogaster. bioRxiv:10.64898/2025.12.01.691737 (Accepted in PLoS Genetics)

5. Zakerzade R#, Chang C-H#, Chatla K, Krishnapura A, Appiah SP, Zhang J, Unckless RL, Blumenstiel JP, Bachtrog D, Wei KH* (2024) Diversification and recurrent adaptation of the synaptonemal complex in Drosophila. PLoS Genet 21(1): e101154

6. Lin L, Huang Y, McIntyre J, Chang C-H, Colmenares S, Lee YCG*. (2024) Prevalent fast evolution of genes involved in heterochromatin functions. Mol. Biol. Evol. 41(9):msae181

7. Courret C*, Hemmer L, Wei X, Patel PD, Santinello B, Geng X, Chang C.-H., Mellone BG, Larracuente AM* (2024) Turnover of retroelements and satellite DNA drives centromere reorganization over short evolutionary timescales in Drosophila. PLoS Biol 22(11): e3002911 

8. Dubruille R#*, Herbette M#, Revel M, Horard B, Chang C-H, Loppin B* (2023) Histone removal in sperm protects paternal chromosomes from premature division at fertilization. Science. 2023; 382(6671):725-31.

9. Chang C-H*, Mejia Natividad I and Malik HS (2023) Expansion and loss of sperm nuclear basic protein genes in Drosophila correspond with genetic conflicts between sex chromosomes. eLife 12:e85249. 

10. Chang C-H*, Gregory EL, Gordon KE, Meiklejohn CD and Larracuente AM* (2022) Unique structure and positive selection promote the rapid divergence of Drosophila Y chromosomes. eLife 11:e75795.

11. Navarro-Domínguez B, Chang C-H, Brand CL, Murihead CA, Presgraves DC* and Larracuente AM* (2022) Epistatic selection on a selfish Segregation Distorter supergene – drive, recombination, and genetic load. eLife 11:e78981.

12. Herbette M, Wei X, Chang C-H, Larracuente AM, Loppin B, and Dubruille R* (2021). Distinct spermiogenic phenotypes underlie sperm elimination in the Segregation Distorter meiotic drive system. PLoS Genet, 17(7): e1009662.

13. Chakraborty M#, Chang C-H#, Khost D, Vedanayagam J, Adrion JR, Liao Y, Montooth KL, Meiklejohn CD, Larracuente AM*, and Emerson JJ* (2021). Evolution of genome structure in the Drosophila simulans species complex. Genome Research, 31, 380-396.

14. Chang C-H#, Chavan A #, Palladino J#, Wei X, Martins NMC., Santinello B, Chen CC, Erceg J, Beliveau BJ, Wu CT, Larracuente AM*, and Mellone BG* (2019). Islands of retroelements are major components of Drosophila centromeres. PLoS Biology, 17(5), e3000241. (F1000 recommended)

15. Chang C-H*, and Larracuente AM* (2019). Heterochromatin-Enriched Assemblies Reveal the Sequence and Organization of the Drosophila melanogaster Y Chromosome. Genetics, 211(1), 333-348. (Highlight article, F1000 recommended)

16. Lo C-W, Kryvalap Y, Sheu T-j, Chang C-H, and Czyzyk J* (2019). Cellular proliferation in mouse and human pancreatic islets is regulated by serpin B13 inhibition and downstream targeting of E-cadherin by cathepsin L. Diabetologia, 62(5), 822-834.

17. Fallon TR#, Lower SE#, Chang C-H, Bessho-Uehara M, Martin GJ, Bewick AJ, Behringer M, Debat HJ, Wong I, Day JC, Suvorov A, Silva CJ, Stanger-Hall KF, Hall DW, Schmitz RJ, Nelson DR, Lewis SM, Shigenobu S, Bybee SM, Larracuente AM, Oba Y, and Weng JK* (2018). Firefly genomes illuminate parallel origins of bioluminescence in beetles. eLife 2018;7:e36495.

18. Chang C-H*, and Larracuente AM (2017). Genomic changes following the reversal of a Y chromosome to an autosome in Drosophila pseudoobscura. Evolution, 71(5), 1285-1296.

19. Martinson EO#*, Mrinalini#, Kelkar YD, Chang C-H, and Werren JH* (2017). The Evolution of Venom by Co-option of Single-Copy Genes. Current Biology, 27(13), 2007-2013 e2008.

20. Chang C-C#, Ting C-T#, Chang C-H, Fang S*, and Chang H-y* (2014). The persistence of facultative parthenogenesis in Drosophila albomicans. PLoS One, 9(11), e113275. 

21. Cheng C-H#, Chang C-H#, and Chang H-y* (2011). Early-stage evolution of the neo-Y chromosome in Drosophila albomicans. Zoological Studies, 50, 338-349. 

Reviews/ Perspective articles:

1. Chang C-H and Malik HS*. (2021) Putting the brakes on centromere-drive in Mimulus. PLoS Genet 17(4): e1009494 (Perspective)

2. Courret C*, Chang C-H, Wei KH, Montchamp-Moreau C, and Larracuente AM (2019). Meiotic drive mechanisms: lessons from Drosophila. Proc Biol Sci, 286(1913), 20191430. (Review)