The Belgian violinist and nyckelharpa player Didier François loves encounters. His discography (ten albums) includes Renaud Garcia-Fons (double bass), the Swedish singer Ulrika Boden, Lévon Minassian (doudouk player of Peter Gabriel) and the hurdy-gurdy player Gilles Chabenat with whom he recorded a double CD together with the French singer Gabriel Yacoub. With the Italian nyckelharpa player Marco Ambrosini he recorded Bartòk's 44 violin duos (reworked for nyckelharpa). With voices such as those of Neeka, Tom Theuns and Patrick Riguelle Didier performed texts by Wannes Van De Velde in his own unique way. Trilok Gurtu was a guest on the CD "Wispered Wishes" that he made with jazz pianist Michel Bisceglia. To this day they regularly perform together.

Moreover, Didier's path crossed that of Stéphane Grappelli and he was also a soloist in the live screening of "Lord of the Rings", composed by the American film composer Howard Shore. With the French film composer Armand Amar (awarded by a César for the music of "Le Concert", film by Radu Mihaileanu) he collaborated on the film and ballet music for directors such as Costa-Gavras (for the films "Amen" and "Le Couperet"), Yann Arthus-Bertrand (for the documentary "La terre vue du ciel").  With Trevor Morris he composed the pilot of the American television series Vikings. Since 2015 Didier also collaborates with film composer Michel Bisceglia (awarded for the film "Marina" by Stijn Coninx) in the series Jan de Lichte . For ten years Didier was jointly responsible for the musical direction of the Brussels theatrical ensemble Leporello.

Didier François has been particularly fascinated by early music in recent years. He played together with the famous lutenist Rolf Lislevand, the Gambisten Romina Lischka and Thomas Baeté, the ensemble Utopia and the international collective Ratas del viejo mundo are also frequent musicians. Together with his companion the route Philippe Malfeyt, Didier passionately associated renaissance and baroque music with jazz elements. He now continues along this original path with Michel Bisceglia, with whom he jazzed up the early music repertoire both in duo and quartet. Didier Francois' repertoire is gradually permeated by numerous eclectic influences.

Thanks to the playing technique of the Belgian violinist Arthur Grumiaux, Didier François was able to perfect a technique for the nyckelharpa, based on relaxation and flowing movements. This innovative way of playing allows more freedom of movement, allowing the musician to deepen the quality of his sounds. Moreover, this innovation increases the possibilities of composing contemporary interpretations that can broaden the repertoire of nyckelharpa (hitherto mainly known by Swedish folk music). Today, thanks to the clarity of the sound mixed with the resonance of the sympathetic strings, Didier's work offers an exceptional richness of keyboards in Bach, Ysaïe and Satie, but also in many of his own compositions, often based on themes from the traditional patrimony.

Didier François also teaches at the Mechelen Conservatory and in Germany and Italy.